A facile, efficient and substrate-selective oxidation of the primary amines with NaClO as oxidant catalyzed by β-cyclodextrin (β-CD) has been developed in water for the first time, and the behavior of β-cyclodextrin that catalyzed the primary amines to nitriles in water was investigated. It was found that the primary amines which could form host-guest complexes with β-cyclodextrin were oxidized to nitriles with excellent yields at ambient temperature. The results show that β-cyclodextrin worked not only as a solubilizing agent but also as a catalyst in these reactions.
Corresponding Author(s):
JI Hongbing,Email:jihb@mail.sysu.edu.cn
引用本文:
. β-Cyclodextrin promoted oxidation of primary amines to nitriles in water[J]. Frontiers of Chemical Engineering in China, 2009, 3(2): 196-200.
Dongpo SHI, Hongbing JI, Zhong LI. β-Cyclodextrin promoted oxidation of primary amines to nitriles in water. Front Chem Eng Chin, 2009, 3(2): 196-200.
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