1. College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China; 2. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China
Bioactive glasses (BGs) are ideal materials for macroporous scaffolds due to their excellent osteoconductive, osteoinductive, biocompatible and biodegradable properties, and their high bone bonding rates. Macroporous scaffolds made from BGs are in high demand for bone regeneration because they can stimulate vascularized bone ingrowth and they enhance bonding between scaffolds and surrounding tissues. Engineering BG/biopolymers (BP) composites or hybrids may be a good way to prepare macroporous scaffolds with excellent properties. This paper summarizes the progress in the past few years in preparing three-dimensional macroporous BG and BG/BP scaffolds for bone regeneration. Since the brittleness of BGs is a major problem in developing macroporous scaffolds and this limits their use in load bearing applications, the mechanical properties of macroporous scaffolds are particularly emphasized in this review.
Corresponding Author(s):
JI Lijun,Email:ljji@yzu.edu.cn; QIU Dong,Email:dqiu@iccas.ac.cn
引用本文:
. Progress of three-dimensional macroporous bioactive glass for bone regeneration[J]. Frontiers of Chemical Science and Engineering, 2012, 6(4): 470-483.
Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU. Progress of three-dimensional macroporous bioactive glass for bone regeneration. Front Chem Sci Eng, 2012, 6(4): 470-483.
Hench L L, Thompson I. Twenty-first century challenges for biomaterials. Journal of the Royal Society, Interface , 2010, 7(Suppl_4): S379–S391 doi: 10.1098/rsif.2010.0151.focus
2
Arcos D, Vallet-Regi M. Sol-gel silica-based biomaterials and bone tissue regeneration. Acta Biomaterialia , 2010, 6(8): 2874–2888 doi: 10.1016/j.actbio.2010.02.012
3
Boccaccini A R, Keim S, Ma R, Li Y, Zhitomirsky I. Electrophoretic deposition of biomaterials. Journal of the Royal Society, Interface , 2010, 7(Suppl_5): S581–S613 doi: 10.1098/rsif.2010.0156.focus
4
Gorustovich A A, Roether J A, Boccaccini A R. Effect of bioactive glasses on angiogenesis: a review of in vitro and in vivo evidences. Tissue Engineering Part B: Reviews, 2010, 16(2): 199–207 doi: 10.1089/ten.teb.2009.0416
5
Hertz A, Bruce I J. Inorganic materials for bone repair or replacement applications. Nanomedicine; Nanotechnology, Biology, and Medicine , 2007, 2: 899–918
6
Hench L L, Xynos I D, Polak J M. Bioactive glasses for in situ tissue regeneration. Journal of Biomaterials Science. Polymer Edition , 2004, 15(4): 543–562 doi: 10.1163/156856204323005352
7
Hench L L, Splinter R J, Allen W C, Greenlee T K. Bonding mechanisms at the interface of ceramic prosthetic materials. Journal of Biomedical Materials Research , 1971, 5(6): 117–141 doi: 10.1002/jbm.820050611
8
Hulbert S F, Young F A, Mathews R S, Klawitter J J, Talbert C D, Stelling F H. Potential of ceramic materials as permanently skeletal prostheses. Journal of Biomedical Materials Research , 1970, 4(3): 433–456 doi: 10.1002/jbm.820040309
9
Gauthier O, Bouler J M, Aguado E, Pilet P, Daculsi G. Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth. Biomaterials , 1998, 19(1-3): 133–139 doi: 10.1016/S0142-9612(97)00180-4
10
Hutmacher D W. Scaffold design and fabrication technologies for engineering tissues—state of the art and future perspectives. Journal of Biomaterials Science. Polymer Edition , 2001, 12(1): 107–124 doi: 10.1163/156856201744489
11
Guarino V, Causa F, Ambrosio L. Bioactive scaffolds for bone and ligament tissue. Expert Review of Medical Devices , 2007, 4(3): 405–418 doi: 10.1586/17434440.4.3.405
12
Moroni L, De Wijn J R, Van Blitterswijk C A. Integrating novel technologies to fabricate smart scaffolds. Journal of Biomaterials Science. Polymer Edition , 2008, 19(5): 543–572 doi: 10.1163/156856208784089571
13
Mourino V, Boccaccini A R. Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds. Journal of the Royal Society, Interface , 2010, 7(43): 209–227 doi: 10.1098/rsif.2009.0379
14
Baroli B. From natural bone grafts to tissue engineering therapeutics: brainstorming on pharmaceutical formulative requirements and challenges. Journal of Pharmaceutical Sciences , 2009, 98(4): 1317–1375 doi: 10.1002/jps.21528
15
Habraken W, Wolke J G C, Jansen J A. Ceramic composites as matrices and scaffolds for drug delivery in tissue engineering. Advanced Drug Delivery Reviews , 2007, 59(4-5): 234–248 doi: 10.1016/j.addr.2007.03.011
16
Lee S H, Shin H. Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering. Advanced Drug Delivery Reviews , 2007, 59(4-5): 339–359 doi: 10.1016/j.addr.2007.03.016
17
Chung H J, Park T G. Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering. Advanced Drug Delivery Reviews , 2007, 59(4-5): 249–262 doi: 10.1016/j.addr.2007.03.015
18
Ginebra M P, Traykova T, Planell J A. Calcium phosphate cements as bone drug delivery systems: a review. Journal of Controlled Release , 2006, 113(2): 102–110 doi: 10.1016/j.jconrel.2006.04.007
19
Seeherman H, Wozney J M. Delivery of bone morphogenetic proteins for orthopedic tissue regeneration. Cytokine & Growth Factor Reviews , 2005, 16(3): 329–345 doi: 10.1016/j.cytogfr.2005.05.001
20
Saltzman W M, Olbricht W L. Building drug delivery into tissue engineering. Nature Reviews. Drug Discovery , 2002, 1(3): 177–186 doi: 10.1038/nrd744
21
Stevens M M, George J H. Exploring and engineering the cell surface interface. Science , 2005, 310(5751): 1135–1138 doi: 10.1126/science.1106587
22
Rezwan K, Chen Q Z, Blaker J J, Boccaccini A R. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering. Biomaterials , 2006, 27(18): 3413–3431 doi: 10.1016/j.biomaterials.2006.01.039
23
Li R, Clark A E, Hench L L. An investigation of bioactive glass powders by sol-gel processing. Journal of Applied Biomaterials , 1991, 2(4): 231–239 doi: 10.1002/jab.770020403
24
Jones J R, Lin S, Yue S, Lee P D, Hanna J V, Smith M E, Newport R J. Bioactive glass scaffolds for bone regeneration and their hierarchical characterisation. Journal of Engineering in Medicine, 2010, 224(12): 1373–1387 doi: 10.1243/09544119JEIM836
25
Qiu D, Martin R A, Knowles J C, Smith M E, Newport R J. A comparative study of the structure of sodium borophosphates made by sol-gel and melt-quench methods. Journal of Non-Crystalline Solids , 2010, 356(9-10): 490–494 doi: 10.1016/j.jnoncrysol.2009.12.016
26
Li A, Wang D, Xiang J, Newport R J, Reinholdt M X, Mutin P H, Vantelon D, Bonhomme C, Smith M E, Laurencin D, Qiu D. Insights into new calcium phosphosilicate xerogels using an advanced characterization methodology. Journal of Non-Crystalline Solids , 2011, 357(19-20): 3548–3555 doi: 10.1016/j.jnoncrysol.2011.07.003
27
Qiu D, Guerry P, Knowles J C, Smith M E, Newport R J. Formation of functional phosphosilicate gels from phytic acid and tetraethyl orthosilicate. Journal of Sol-Gel Science and Technology , 2008, 48(3): 378–383 doi: 10.1007/s10971-008-1818-9
28
Li A, Qiu D. Phytic acid derived bioactive CaO-P2O5-SiO2 gel-glasses. Journal of Materials Science. Materials in Medicine , 2011, 22(12): 2685–2691 doi: 10.1007/s10856-011-4464-7
Vitale-Brovarone C, Verne E, Robiglio L, Appendino P, Bassi F, Martinasso G, Muzio G, Canuto R. Development of glass-ceramic scaffolds for bone tissue engineering: characterisation, proliferation of human osteoblasts and nodule formation. Acta Biomaterialia , 2007, 3(2): 199–208 doi: 10.1016/j.actbio.2006.07.012
31
Liu X, Rahaman M N, Fu Q A. Oriented bioactive glass (13-93) scaffolds with controllable pore size by unidirectional freezing of camphene-based suspensions: microstructure and mechanical response. Acta Biomaterialia , 2011, 7(1): 406–416 doi: 10.1016/j.actbio.2010.08.025
32
Vitale-Brovarone C, Di Nunzio S, Bretcanu O, Verne E. Macroporous glass-ceramic materials with bioactive properties. Journal of Materials Science. Materials in Medicine , 2004, 15(3): 209–217 doi: 10.1023/B:JMSM.0000015480.49061.e1
33
Saboori A, Sheikhi M, Moztarzadeh F, Rabiee M, Hesaraki S, Tahriri M, Nezafati N. Sol-gel preparation, characterisation and in vitro bioactivity of Mg containing bioactive glass. Advances in Applied Ceramics , 2009, 108(3): 155–161 doi: 10.1179/174367608X324054
34
Perez-Pariente J, Balas F, Roman J, Salinas A J, Vallet-Regi M. Influence of composition and surface characteristics on the in vitro bioactivity of SiO2-CaO-P2O5-MgO sol-gel glasses. Journal of Biomedical Materials Research , 1999, 47: 170–175 doi: 10.1002/(SICI)1097-4636(199911)47:2<170::AID-JBM6>3.0.CO;2-J
35
Salinas A J, Roman J, Vallet-Regi M, Oliveira J M, Correia R N, Fernandes M H. In vitro bioactivity of glass and glass-ceramics of the 3CaO center dot P2O5-CaO center dot SiO2-CaO center dot MgO center dot 2SiO(2) system. Biomaterials , 2000, 21: 251–257 doi: 10.1016/S0142-9612(99)00150-7
36
Saboori A, Rabiee M, Mutarzadeh F, Sheikhi M, Tahriri M, Karimi M. Synthesis, characterization and in vitro bioactivity of sol-gel-derived SiO2-CaO-P2O5-MgO bioglass. Mater Sci Eng C Biomim Supramol Syst , 2009, 29(1): 335–340 doi: 10.1016/j.msec.2008.07.004
37
Jones J R, Ehrenfried L M, Saravanapavan P, Hench L L. Controlling ion release from bioactive glass foam scaffolds with antibacterial properties. Journal of Materials Science. Materials in Medicine , 2006, 17(11): 989–996 doi: 10.1007/s10856-006-0434-x
38
Vitale-Brovarone C, Miola M, Alagna C B, Verne E. 3D-glass-ceramic scaffolds with antibacterial properties for bone grafting. Chemical Engineering Journal , 2008, 137(1): 129–136 doi: 10.1016/j.cej.2007.07.083
39
Courtheoux L, Lao J, Nedelec J M, Jallot E. Controlled bioactivity in zinc-doped sol-gel-derived binary bioactive glasses. Journal of Physical Chemistry C , 2008, 112(35): 13663–13667 doi: 10.1021/jp8044498
40
Bini M, Grandi S, Capsoni D, Mustarelli P, Saino E, Visai L. SiO2-P2O5-CaO glasses and glass-ceramics with and without ZnO: relationships among composition, microstructure, and bioactivity. Journal of Physical Chemistry C , 2009, 113(20): 8821–8828 doi: 10.1021/jp810977w
41
Lao J, Jallot E, Nedelec J M. Strontium-delivering glasses with enhanced bioactivity: a new biomaterial for antiosteoporotic applications? Chemistry of Materials , 2008, 20(15): 4969–4973 doi: 10.1021/cm800993s
42
Nakamura T, Yamamuro T, Higashi S, Kokubo T, Itoo S. A new glass-ceramic for bone-replacement-evaluation of its bonding to bone tissue. Journal of Biomedical Materials Research , 1985, 19(6): 685–698 doi: 10.1002/jbm.820190608
43
Ono K, Yamamuro T, Nakamura T, Kokubo T. Mechanical-properties of bone after implantation of apatite wollastonite containing glass ceramic fibrin mixture. Journal of Biomedical Materials Research , 1990, 24(1): 47–63 doi: 10.1002/jbm.820240106
44
Kawanabe K, Iida H, Matsusue Y, Nishimatsu H, Kasai R, Nakamura T. A-W glass ceramic as a bone substitute in cemented hip arthroplasty-15 hips followed 2-10 years. Acta Orthopaedica , 1998, 69(3): 237–242 doi: 10.3109/17453679809000922
45
Yang W, Zhou D, Yin G, Zheng C. Research and development of A-W bioactive glass ceramic. Journal of Biomedical Engineer , 2003, 20(3): 541–545 (in Chinese)
46
Yang W, Zhou D, Yin G, Chen H, Xiao B, Zhang Y. Study on a new type of apatite/wollastonite porous bioactive glass-ceramic. Journal of Biomedical Engineer , 2004, 21: 913–916 (in Chinese)
47
Shinzato S, Kobayashi M, Mousa W F, Kamimura M, Neo M, Kitamura Y, Kokubo T, Nakamura T. Bioactive polymethyl methacrylate-based bone cement: comparison of glass beads, apatite- and wollastonite-containing glass-ceramic, and hydroxyapatite fillers on mechanical and biological properties. Journal of Biomedical Materials Research , 2000, 51(2): 258–272 doi: 10.1002/(SICI)1097-4636(200008)51:2<258::AID-JBM15>3.0.CO;2-S
48
Juhasz J A, Best S M, Brooks R, Kawashita M, Miyata N, Kokubo T, Nakamura T, Bonfield W. Mechanical properties of glass-ceramic A-W-polyethylene composites: effect of filler content and particle size. Biomaterials , 2004, 25(6): 949–955 doi: 10.1016/j.biomaterials.2003.07.005
49
Van de Velde K, Kiekens P. Biopolymers: overview of several properties and consequences on their applications. Polymer Testing , 2002, 21(4): 433–342 doi: 10.1016/S0142-9418(01)00107-6
50
Suyatma N E, Tighzert L, Copinet A, Coma V. Effects of hydrophilic plasticizers on mechanical, thermal, and surface properties of chitosan films. Journal of Agricultural and Food Chemistry , 2005, 53(10): 3950–3957 doi: 10.1021/jf048790+
51
Wang Y, Qiu D, Cosgrove T, Denbow M L. A small-angle neutron scattering and rheology study of the composite of chitosan and gelatin. Colloids and Surfaces B: Biointerfaces , 2009, 70: 254–258
52
Arvanitoyannis I, Kolokuris I, Nakayama A, Yamamoto N, Aiba S. Physico-chemical studies of chitosan-poly(vinyl alcohol) blends plasticized with sorbitol and sucrose. Carbohydrate Polymers , 1997, 34(1-2): 9–19 doi: 10.1016/S0144-8617(97)00089-1
53
Van Vlierberghe S, Dubruel P, Schacht E. Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review. Biomacromolecules , 2011, 12(5): 1387–1408 doi: 10.1021/bm200083n
54
Suyatma N E, Copinet A, Tighzert L, Coma V. Mechanical and barrier properties of biodegradable films made from chitosan and poly (lactic acid) blends. Journal of Polymers and the Environment , 2004, 12(1): 1–6 doi: 10.1023/B:JOOE.0000003121.12800.4e
55
Sarasam A, Madihally S V. Characterization of chitosan-polycaprolactone blends for tissue engineering applications. Biomaterials , 2005, 26(27): 5500–5508 doi: 10.1016/j.biomaterials.2005.01.071
56
Santos C, Seabra P, Veleirinho B, Delgadillo I, da Silva J A L. Acetylation and molecular mass effects on barrier and mechanical properties of shortfin squid chitosan membranes. European Polymer Journal , 2006, 42(12): 3277–3285 doi: 10.1016/j.eurpolymj.2006.09.001
57
Costa E S, Barbosa-Stancioli E F, Mansur A A P, Vasconcelos W L, Mansur H S. Preparation and characterization of chitosan/poly(vinyl alcohol) chemically crosslinked blends for biomedical applications. Carbohydrate Polymers , 2009, 76(3): 472–481 doi: 10.1016/j.carbpol.2008.11.015
58
Khan M, Ferdous S, Mustafa A I. Improvement of physico-mechanical properties of chitosan films by photocuring with acrylic monomers. Journal of Polymers and the Environment , 2005, 13(2): 193–201 doi: 10.1007/s10924-005-2950-z
59
Ji B, Gao H. Mechanical properties of nanostructure of biological materials. Journal of the Mechanics and Physics of Solids , 2004, 52(9): 1963–1990 doi: 10.1016/j.jmps.2004.03.006
60
Sionkowska A, Wisniewski M, Skopinska J, Poggi G F, Marsano E, Maxwell C A, Wess T J. Thermal and mechanical properties of UV irradiated collagen/chitosan thin films. Polymer Degradation & Stability , 2006, 91(12): 3026–3032 doi: 10.1016/j.polymdegradstab.2006.08.009
61
Saito H, Murabayashi S, Mitamura Y, Taguchi T. Characterization of alkali-treated collagen gels prepared by different crosslinkers. Journal of Materials Science. Materials in Medicine , 2008, 19(3): 1297–1305 doi: 10.1007/s10856-007-3239-7
62
Sheu M T, Huang J C, Yeh G C, Ho H O. Characterization of collagen gel solutions and collagen matrices for cell culture. Biomaterials , 2001, 22(13): 1713–1719 doi: 10.1016/S0142-9612(00)00315-X
63
Yang L, Van der Werf K O, Fitie C F C, Bennink M L, Dijkstra P J, Feijen J. Mechanical properties of native and cross-linked type I collagen fibrils. Biophysical Journal , 2008, 94(6): 2204–2211 doi: 10.1529/biophysj.107.111013
64
van der Rijt J A J, van der Werf K O, Bennink M L, Dijkstra P J, Feijen J. Micromechanical testing of individual collagen fibrils. Macromolecular Bioscience , 2006, 6(9): 697–702 doi: 10.1002/mabi.200600063
65
Sionkowska A, Skopinska-Wisniewska J, Gawron M, Kozlowska J, Planecka A. Chemical and thermal cross-linking of collagen and elastin hydrolysates. International Journal of Biological Macromolecules , 2010, 47(4): 570–577 doi: 10.1016/j.ijbiomac.2010.08.004
66
Nam K, Kimura T, Kishida A. Preparation and characterization of cross-linked collagen-phospholipid polymer hybrid gels. Biomaterials , 2007, 28(1): 1–8 doi: 10.1016/j.biomaterials.2006.08.002
67
Liu W, Deng C, McLaughlin C R, Fagerholm P, Lagali N S, Heyne B, Scaiano J C, Watsky M A, Kato Y, Munger R, Shinozaki N, Li F F, Griffith M. Collagen-phosphorylcholine interpenetrating network hydrogels as corneal substitutes. Biomaterials , 2009, 30(8): 1551–1559 doi: 10.1016/j.biomaterials.2008.11.022
68
Yamauchi K, Takeuchi N, Kurimoto A, Tanabe T. Films of collagen crosslinked by S-S bonds: preparation and characterization. Biomaterials , 2001, 22(8): 855–863 doi: 10.1016/S0142-9612(00)00249-0
69
Lim L T, Mine Y, Tung M A. Barrier and tensile properties of transglutaminase cross-linked gelatin films as affected by relative humidity, temperature, and glycerol content. Journal of Food Science , 1999, 64(4): 616–622 doi: 10.1111/j.1365-2621.1999.tb15096.x
70
Usta M, Piech D L, MacCrone R K, Hillig W B. Behavior and properties of neat and filled gelatins. Biomaterials , 2003, 24(1): 165–172 doi: 10.1016/S0142-9612(02)00274-0
71
de Carvalho R A, Grosso C R F. Characterization of gelatin based films modified with transglutaminase, glyoxal and formaldehyde. Food Hydrocolloids , 2004, 18(5): 717–722 doi: 10.1016/j.foodhyd.2003.10.005
72
Cao N, Fu Y, He J. Mechanical properties of gelatin films cross-linked, respectively, by ferulic acid and tannin acid. Food Hydrocolloids , 2007, 21(4): 575–584 doi: 10.1016/j.foodhyd.2006.07.001
73
Fakirov Z S. Anbar T, Boz B, Bahar I, Evstatiev M, Apostolov A A, Mark J E, Kloczkowski A. Mechanical properties and transition temperatures of cross-linked oriented gelatin: 1.Static and dynamic mechanical properties of cross-linked gelatin. Colloid & Polymer Science , 1996, 274: 334–341
74
Santin M, Huang S J, Iannace S, Ambrosio L, Nicolais L, Peluso G. Synthesis and characterization of a new interpenetrated poly(2-hydroxyethylmethacrylate)-gelatin composite polymer. Biomaterials , 1996, 17(15): 1459–1467 doi: 10.1016/0142-9612(96)89769-9
75
Vemuri S. A screening technique to study the mechanical strength of gelatin formulations. Drug Development and Industrial Pharmacy , 2000, 26(10): 1115–1120 doi: 10.1081/DDC-100100277
76
Bigi A, Bracci B, Cojazzi G, Panzavolta S, Roveri N. Drawn gelatin films with improved mechanical properties. Biomaterials , 1998, 19(24): 2335–2340 doi: 10.1016/S0142-9612(98)00149-5
77
Bigi A, Cojazzi G, Panzavolta S, Rubini K, Roveri N. Mechanical and thermal properties of gelatin films at different degrees of glutaraldehyde crosslinking. Biomaterials , 2001, 22(8): 763–768 doi: 10.1016/S0142-9612(00)00236-2
78
Yakimets I, Wellner N, Smith A C, Wilson R H, Farhat I, Mitchell J. Mechanical properties with respect to water content of gelatin films in glassy state. Polymer , 2005, 46(26): 12577–12585 doi: 10.1016/j.polymer.2005.10.090
79
Lee K Y, Shim J, Lee H G. Mechanical properties of gellan and gelatin composite films. Carbohydrate Polymers , 2004, 56(2): 251–254 doi: 10.1016/j.carbpol.2003.04.001
80
Bigi A, Panzavolta S, Rubini K. Relationship between triple-helix content and mechanical properties of gelatin films. Biomaterials , 2004, 25(25): 5675–5680 doi: 10.1016/j.biomaterials.2004.01.033
81
Gómez-Guillén M C, Perez-Mateos M, Gomez-Estaca J, Lopez-Caballero E, Gimenez B, Montero P. Fish gelatin: a renewable material for developing active biodegradable films. Trends in Food Science & Technology , 2009, 20(1): 3–16 doi: 10.1016/j.tifs.2008.10.002
82
Arvanitoyannis I, Nakayama A, Aiba S I. Edible films made from hydroxypropyl starch and gelatin and plasticized by polyols and water. Carbohydrate Polymers , 1998, 36(2-3): 105–119 doi: 10.1016/S0144-8617(98)00017-4
83
Arvanitoyannis I S, Nakayama A, Aiba S I. Chitosan and gelatin based edible films: state diagrams, mechanical and permeation properties. Carbohydrate Polymers , 1998, 37(4): 371–382 doi: 10.1016/S0144-8617(98)00083-6
84
Park J W, Scott Whiteside W, Cho S Y. Mechanical and water vapor barrier properties of extruded and heat-pressed gelatin films. LWT- Food Science and Technology , 2008, 41(4): 692–700 doi: 10.1016/j.lwt.2007.04.015
85
Koob T J, Hernandez D J. Mechanical and thermal properties of novel polymerized NDGA-gelatin hydrogels. Biomaterials , 2003, 24(7): 1285–1292 doi: 10.1016/S0142-9612(02)00465-9
86
Karageorgiou V, Kaplan D. Porosity of 3D biornaterial scaffolds and osteogenesis. Biomaterials , 2005, 26(27): 5474–5491 doi: 10.1016/j.biomaterials.2005.02.002
87
Jones J R, Ehrenfried L M, Hench L L. Optimising bioactive glass scaffolds for bone tissue engineering. Biomaterials , 2006, 27(7): 964–973 doi: 10.1016/j.biomaterials.2005.07.017
88
FitzGerald V, Martin R A, Jones J R, Qiu D, Wetherall K M, Moss R M, Newport R J. Bioactive glass sol-gel foam scaffolds: Evolution of nanoporosity during processing and in situ monitoring of apatite layer formation using small- and wide-angle X-ray scattering. Journal of Biomedical Materials Research. Part A , 2009, 91A(1): 76–83 doi: 10.1002/jbm.a.32206
89
Wu Z Y, Hill R G, Yue S, Nightingale D, Lee P D, Jones J R. Melt-derived bioactive glass scaffolds produced by a gel-cast foaming technique. Acta Biomaterialia , 2011, 7(4): 1807–1816 doi: 10.1016/j.actbio.2010.11.041
90
Chen Q Z Z, Thompson I D, Boccaccini A R. 45S5 Bioglass?-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials , 2006, 27(11): 2414–2425 doi: 10.1016/j.biomaterials.2005.11.025
91
Liu X, Huang W H, Fu H L, Yao A H, Wang D P, Pan H B, Lu W W. Bioactive borosilicate glass scaffolds: improvement on the strength of glass-based scaffolds for tissue engineering. Journal of Materials Science. Materials in Medicine , 2009, 20(1): 365–372 doi: 10.1007/s10856-008-3582-3
92
Xue M, Feng D G, Li G D, Yang W Z, Zhou D L. Preparation of porous apatite-wollastonite bioactive glass ceramic (AW-GC) by dipping with polymer foams. Chinese Journal of Inorganic Chemistry , 2007, 23: 708–712
93
Cao B, Zhou D, Xue M, Li G, Yang W, Long Q, Ji L. Study on surface modification of porous apatite-wollastonite bioactive glass ceramic scaffold. Applied Surface Science , 2008, 255(2): 505–508 doi: 10.1016/j.apsusc.2008.06.066
94
Baino F, Verne E, Vitale-Brovarone C. 3-D high-strength glass-ceramic scaffolds containing fluoroapatite for load-bearing bone portions replacement. Materials Science and Engineering: C , 2009, 29(6): 2055–2062 doi: 10.1016/j.msec.2009.04.002
95
Bellucci D, Cannillo V, Sola A, Chiellini F, Gazzarri M, Migone C. Macroporous Bioglass?-derived scaffolds for bone tissue regeneration. Ceramics International , 2011, 37(5): 1575–1585 doi: 10.1016/j.ceramint.2011.01.023
96
Yan H, Zhang K, Blanford C F, Francis L F, Stein A. In vitro hydroxycarbonate apatite mineralization of CaO-SiO2 sol-gel glasses with a three-dimensionally ordered macroporous structure. Chemistry of Materials , 2001, 13(4): 1374–1382 doi: 10.1021/cm000895e
97
Yan P H, Wang J Q, Ou J F, Li Z P, Lei Z Q, Yang S R. Synthesis and characterization of three-dimensional ordered mesoporous-macroporous bioactive glass. Materials Letters , 2010, 64(22): 2544–2547 doi: 10.1016/j.matlet.2010.08.033
98
Wei G F, Yan X X, Yi J, Zhao L Z, Zhou L, Wang Y H, Yu C Z. Synthesis and in-vitro bioactivity of mesoporous bioactive glasses with tunable macropores. Microporous and Mesoporous Materials , 2011, 143(1): 157–165 doi: 10.1016/j.micromeso.2011.02.024
99
Hajiali H, Karbasi S, Hosseinalipour M, Rezaie H R. Preparation of a novel biodegradable nanocomposite scaffold based on poly (3-hydroxybutyrate)/bioglass nanoparticles for bone tissue engineering. Journal of Materials Science , 2010, 21(7): 2125–2133 doi: 10.1007/s10856-010-4075-8
100
Ryszkowska J L, Auguscik M, Sheikh A, Boccaccini A R. Biodegradable polyurethane composite scaffolds containing Bioglass? for bone tissue engineering. Composites Science and Technology , 2010, 70(13): 1894–1908 doi: 10.1016/j.compscitech.2010.05.011
101
Mozafari M, Moztarzadeh F, Rabiee M, Azami M, Maleknia S, Tahriri M, Moztarzadeh Z, Nezafati N. Development of macroporous nanocomposite scaffolds of gelatin/bioactive glass prepared through layer solvent casting combined with lamination technique for bone tissue engineering. Ceramics International , 2010, 36(8): 2431–2439 doi: 10.1016/j.ceramint.2010.07.010
102
Hong Z K, Reis R L, Mano J F. Preparation and in vitro characterization of scaffolds of poly(L-lactic acid) containing bioactive glass ceramic nanoparticles. Acta Biomaterialia , 2008, 4(5): 1297–1306 doi: 10.1016/j.actbio.2008.03.007
103
Barroca N, Daniel-da-Silva A L, Vilarinho P M, Fernandes M H V. Tailoring the morphology of high molecular weight PLLA scaffolds through bioglass addition. Acta Biomaterialia , 2010, 6(9): 3611–3620 doi: 10.1016/j.actbio.2010.03.032
104
Fabbri P, Cannillo V, Sola A, Dorigato A, Chiellini F. Highly porous polycaprolactone-45S5 Bioglass? scaffolds for bone tissue engineering. Composites Science and Technology , 2010, 70(13): 1869–1878 doi: 10.1016/j.compscitech.2010.05.029
105
Minaberry Y, Jobbagy M. Macroporous bioglass scaffolds prepared by coupling sol-gel with freeze drying. Chemistry of Materials , 2011, 23(9): 2327–2332 doi: 10.1021/cm103362c
106
Doiphode N D, Huang T S, Leu M C, Rahaman M N, Day D E. Freeze extrusion fabrication of 13-93 bioactive glass scaffolds for bone repair. Journal of Materials Science. Materials in Medicine , 2011, 22(3): 515–523 doi: 10.1007/s10856-011-4236-4
107
Garcia A, Izquierdo-Barba I, Colilla M, de Laorden C L, Vallet-Regí M. Lopez de laorden C, Vallet-Regi M. Preparation of 3-D scaffolds in the SiO2-P2O5 system with tailored hierarchical meso-macroporosity. Acta Biomaterialia , 2011, 7(3): 1265–1273 doi: 10.1016/j.actbio.2010.10.006
108
Yun H S, Kim S E, Park E K. Bioactive glass-poly(epsilon-caprolactone) composite scaffolds with 3 dimensionally hierarchical pore networks. Materials Science and Engineering: C , 2011, 31(2): 198–205 doi: 10.1016/j.msec.2010.08.020
109
Valliant E M, Jones J R. Softening bioactive glass for bone regeneration: sol-gel hybrid materials. Soft Matter , 2011, 7(11): 5083–5095 doi: 10.1039/c0sm01348j
110
Mahony O, Tsigkou O, Ionescu C, Minelli C, Ling L, Hanly R, Smith M E, Stevens M M, Jones J R. Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration. Advanced Functional Materials , 2010, 20(22): 3835–3845 doi: 10.1002/adfm.201000838
111
Pereira M M, Jones J R, Orefice R L, Hench L L. Preparation of bioactive glass-polyvinyl alcohol hybrid foams by the sol-gel method. Journal of Materials Science . 2005, 16(11): 1045–1050 doi: 10.1007/s10856-005-4758-8
112
Costa H S, Rocha M F, Andrade G I, Barbosa-Stancioli E F, Pereira M M, Orefice R L, Vasconcelos W L, Mansur H S. Sol-gel derived composite from bioactive glass-polyvinyl alcohol. Journal of Materials Science , 2008, 43(2): 494–502 doi: 10.1007/s10853-007-1875-4
113
Costa H S, Stancioli E F B, Pereira M M, Orefice R L, Mansur H S. Synthesis, neutralization and blocking procedures of organic/inorganic hybrid scaffolds for bone tissue engineering applications. Journal of Materials Science , 2009, 20(2): 529–535 doi: 10.1007/s10856-008-3580-5
114
de Oliveira A A R, Ciminelli V, Dantas M S S, Mansur H S, Pereira M M. Acid character control of bioactive glass/polyvinyl alcohol hybrid foams produced by sol-gel. Journal of Sol-Gel Science and Technology , 2008, 47(3): 335–346 doi: 10.1007/s10971-008-1777-1
115
Costa H S, Mansur A A P, Pereira M M, Mansur H S. Engineered hybrid scaffolds of poly(vinyl alcohol)/bioactive glass for potential bone engineering applications: synthesis, characterization, cytocompatibility, and degradation. Journal of Nanomaterials , 2012, 2012: 1–16 doi: 10.1155/2012/718470
116
Lin S, Ionescu C, Pike K J, Smith M E, Jones J R. Nanostructure evolution and calcium distribution in sol-gel derived bioactive glass. Journal of Materials Chemistry , 2009, 19(9): 1276–1282 doi: 10.1039/b814292k