Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores
Fabio de Moliner1, Ina Biazruchka2, Karolina Konsewicz1, Sam Benson1, Suraj Singh1, Jun-Seok Lee3(), Marc Vendrell1()
1. Centre for Inflammation Research, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK 2. Molecular Recognition Research Centre, Korea Institute of Science and Technology (KIST) & Bio-Med Program, KIST-School UST, Seoul 02792, Korea 3. Department of Pharmacology, Korea University College of Medicine, Seoul 02841, Korea
The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.
. [J]. Frontiers of Chemical Science and Engineering, 2022, 16(1): 128-135.
Fabio de Moliner, Ina Biazruchka, Karolina Konsewicz, Sam Benson, Suraj Singh, Jun-Seok Lee, Marc Vendrell. Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores. Front. Chem. Sci. Eng., 2022, 16(1): 128-135.
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