Chemically triggered life control of “smart” hydrogels through click and declick reactions
Xing Feng1, Meiqing Du1, Hongbei Wei1, Xiaoxiao Ruan1, Tao Fu1, Jie Zhang2(), Xiaolong Sun1()
1. Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China 2. The Fourth Military Medical University, Xi’an 710032, China
The degradation of polymeric materials is recognized as one of the goals to be fulfilled for the sustainable economy. In this study, a novel methodology was presented to synthesize multiple highly cross-linked polymers (i.e., hydrogels) through amine–thiol scrambling under mild conditions. Amine-terminated poly(ethylene glycol) (PEG-NH2) was reacted with the representative conjugate acceptors to synthesize hydrogels in organic and aqueous solutions, respectively. The materials above exhibited high water-swelling properties, distributed porous structures, as well as prominent mechanical strengths. It is noteworthy that the mentioned hydrogels could be degraded efficiently in hours to release the original coupling partner, which were induced by ethylene diamine at ambient temperature through amine-amine metathesis. The recovered PEG-NH2 reagent could be employed again to regenerate hydrogels. Due to the multiple architectures and functions in polymeric synthesis, degradation and regeneration, a new generation of “smart” materials is revealed.
. [J]. Frontiers of Chemical Science and Engineering, 2022, 16(9): 1399-1406.
Xing Feng, Meiqing Du, Hongbei Wei, Xiaoxiao Ruan, Tao Fu, Jie Zhang, Xiaolong Sun. Chemically triggered life control of “smart” hydrogels through click and declick reactions. Front. Chem. Sci. Eng., 2022, 16(9): 1399-1406.
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