Multiphase surfactant-assisted reaction-separation system in a microchannel reactor
Multiphase surfactant-assisted reaction-separation system in a microchannel reactor
Salah ALJBOUR1(), Tomohiko TAGAWA1, Mohammad MATOUQ2, Hiroshi YAMADA1
1. Department of Chemical Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan; 2. Faculty of Engineering Technology, Al-Balqa Applied University, Amman 11134, Jordan
The Lewis acid-catalyzed addition of trimethylsilyl cyanide to p-chlorobenzaldehyde in a microchannel reactor was investigated. The microchannel was integrated to promote both reaction and separation of the biphase system. FeF3 and Cu(triflate)2 were used as water-stable Lewis acid catalysts. Sodium dodecyl sulfate was incorporated in the organic-aqueous system to enhance the reactivity and to manipulate the multiphase flow inside the microchannel. It was found that the dynamics and the kinetics of the multiphase reaction were affected by the new micellar system. Parallel multiphase flow inside the microchannel was obtained, allowing for continuous and acceptable phase separation. Enhanced selectivity was achieved by operating at lower conversion values.
. Multiphase surfactant-assisted reaction-separation system in a microchannel reactor[J]. Frontiers of Chemical Engineering in China, 2009, 3(1): 33-38.
Salah ALJBOUR, Tomohiko TAGAWA, Mohammad MATOUQ, Hiroshi YAMADA. Multiphase surfactant-assisted reaction-separation system in a microchannel reactor. Front Chem Eng Chin, 2009, 3(1): 33-38.
Intertsil CN-3, 5 micrometer, 250 mm ′ 4.6 mm ID, GL Science Inc. Japan
column temperature
313 K
eluent
A: hexane, B: ethyl acetate, A/B=70/30, V/V
flow rate
1.0 mL?min–1
injection volume
20 microliter
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1
Li C-J. Organic reactions in aqueous media with a focus on carbon-carbon bond formation. Chem Rev , 1993, 93: 2023-2035 doi: 10.1021/cr00022a004
2
Lindstrom U M. Stereoselective organic reactions in water. Chem Rev , 2002, 102: 2751-2772 doi: 10.1021/cr010122p
3
Kobayashi S, Nagayama S, Busujima T. Lewis acid catalysis in aqueous media: copper (II)-catalyzed aldol and allylation reactions in a water-ethanol-toluene solution. Chem Lett , 1997: 959-960 doi: 10.1246/cl.1997.959
4
Kobayashi S, Wakabayashi T, Nagayama S, Oyamada H. Lewis acid catalysis in micellar systems: Sc(OTf)3-catalyzed aqueous aldol reactions of silyl enol ethers with aldehydes in the presence of a surfactant. Tetrahedron Letters , 1997, 38: 4559-4562 doi: 10.1016/S0040-4039(97)00854-X
5
Killer E, Feringa B L. Highly efficient ytterbium triflate catalyzed michael addition of nitroesters in water. Synlett , 1997: 842 doi: 10.1055/s-1997-5761
6
Otto S, Bertoncin F, Engberts B F N. Lewis acid catalysis of a Diels-Alder reaction in water. J Am Chem Soc , 1996, 118: 7702-7707 doi: 10.1021/ja960318k
7
Bandgar B P, Kamble V T. Organic reactions in aqueous medium: FeF3catalyzed chemoselective addition of cyanotrimethylsilane to aldehydes. Green Chemistry , 2001, 3: 265-266 doi: 10.1039/b106872p
8
Tagawa T, Aljbour S, Matouq M, Yamada H. Micro-channel reactor with guideline structure for organic aqueous binary system. Chem Eng Sci , 2007, 62: 5123-5126 doi: 10.1016/j.ces.2007.03.015
9
Baroud C N, Willaime H. Multiphase flows in microfluidics. C R Physique , 2004, 5: 547-555
10
Shui L, Eijkel J C T, van den Berg A. Multiphase flow in microfluidic systems: control and applications of droplets and interfaces. Advances in Colloid and Interface Science , 2007, 133: 35-49 doi: 10.1016/j.cis.2007.03.001
11
Guuillot P, Colin A. Stability of parallel flows in a microchannel after a T junction, Physical Review , 2005, 72: 066301 doi: 10.1103/PhysRevA.72.066301
12
Reddy V, Zahn J D. Interfacial stabilization of organic-aqueous two-phase microflows for a miniaturized DNA extraction. Journal of Colloid and interface Science , 2005, 286: 158-165
13
Kashid M N, Platte F, Agar D W, Turek S. Computational modelling of slug flow in a capillary microreactor. Journal of Computational and Applied Mathematics , 2007, 203: 487-497 doi: 10.1016/j.cam.2006.04.010
14
Ahmed B, Barrow D, Wirth T. Enhancement of reaction rates by segmented fluid flow in capillary scale reactors. Adv Synth Catal , 2006, 348: 1043-1048 doi: 10.1002/adsc.200505480
