Semi-solid materials for controlled release drug formulation: current status and future prospects

doi:10.1007/s11705-014-1429-7

Front. Chem. Sci. Eng.

2014, Vol. 8

Issue (2) : 225-232 https://doi.org/10.1007/s11705-014-1429-7

REVIEW ARTICLE

Semi-solid materials for controlled release drug formulation: current status and future prospects

Michelle TRAN, Chun WANG(

)

Department of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA

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Abstract

Semi-solid materials represent an important category of inactive ingredients (excipients) of pharmaceutical products. Here we review several common semi-solid polymers currently used in the controlled release formulations of many drugs. These polymers are selected based on their importance and broad scope of application in FDA-approved drug products and include several polysaccharides (cellulose, starch, chitosan, alginate) and carbomers, a group of mucoadhesive synthetic polymers. Glyceride-based polymers used in self-emulsifying drug delivery systems (SEDDS) will also be discussed for its importance in formulating poorly water-soluble drugs. Unique features and advantages of each type of semi-solid materials are discussed and examples of their use in oral delivery of drugs are provided. Finally, future prospects of developing new and better semi-solid excipients are discussed with the objective of facilitating clinical translation.

Keywords semi-solids polymer excipient controlled release drug delivery

Corresponding Author(s): Chun WANG

Issue Date: 22 May 2014

Cite this article:

Michelle TRAN,Chun WANG. Semi-solid materials for controlled release drug formulation: current status and future prospects[J]. Front. Chem. Sci. Eng., 2014, 8(2): 225-232.

URL:

https://academic.hep.com.cn/fcse/EN/10.1007/s11705-014-1429-7
https://academic.hep.com.cn/fcse/EN/Y2014/V8/I2/225

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