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Frontiers of Chemical Science and Engineering

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Front. Chem. Sci. Eng.    2021, Vol. 15 Issue (2) : 221-237    https://doi.org/10.1007/s11705-020-1927-8
REVIEW ARTICLE
Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: a critical review
Simin Feng1, Xiaoli Zhang2, Dunyun Shi3, Zheng Wang1()
1. School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China
2. Central Lab, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China
3. Institute of Hematology, Shenzhen Second People’s Hospital/The First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518035, China
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Abstract

Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.
Keywords zeolitic imidazolate framework-8 (ZIF-8)      synthesis methods      applications      drug delivery     
Corresponding Author(s): Zheng Wang   
Just Accepted Date: 21 March 2020   Online First Date: 09 April 2020    Issue Date: 10 March 2021
 Cite this article:   
Simin Feng,Xiaoli Zhang,Dunyun Shi, et al. Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: a critical review[J]. Front. Chem. Sci. Eng., 2021, 15(2): 221-237.
 URL:  
https://academic.hep.com.cn/fcse/EN/10.1007/s11705-020-1927-8
https://academic.hep.com.cn/fcse/EN/Y2021/V15/I2/221
Fig.1  The crystal structure of ZIF-8. Black and green dots represent the carbon and nitrogen atoms, respectively. Blue polyhedrons stand for the Zn ions. All hydrogen atoms are excluded here. The yellow sphere stands for the largest van der Waals sphere enclosed in the central pore of ZIF-8. Reprinted with permission from ref. [23]. Copyright 2006, the National Academy of Sciences of the USA.
Fig.2  Solvothermal synthesis process of ZIF-8.
Fig.3  Manufacture of zeolitic imidazolate frameworks (ZIF-8 and ZIF-67) in the presence of ammonium hydroxide and nonionic triblock copolymer. Reprinted with permission from ref. [42]. Copyright 2013, The Royal Society of Chemistry.
ZIF Synthesis method Synthesis temperature/°C Synthesis time/h
ZIF-8 US 45 4, 6, 9
ST 140 24
ZIF-7 US 60 3
ZIF-11 US 60 6, 9, 12
ST 100 96
ZIF-20 US 45 3, 6, 9, 12
ST 65 72
Tab.1  Synthesis conditions of ZIF-8, ZIF-7, ZIF-11 and ZIF-20 materials a)
Fig.4  Mechanochemical synthesis of ZIF-8 materials. Reprinted with permission from ref. [54]. Copyright 2013, The Royal Society of Chemistry.
Fig.5  The accelerated aging with selected model ligands. Reprinted with permission from ref. [59]. Copyright 2012, the Royal Society of Chemistry.
Fig.6  Applications of ZIF-8 as nanocarrier in drug delivery.
Fig.7  The pH-induced one-pot synthesis of ZIF-8 to load DOX. Reprinted with permission from ref. [82]. Copyright 2016, American Chemical Society.
Fig.8  The preparation of DOX@ZIF-8/PEG via one-pot method. Reprinted with permission from ref. [83]. Copyright 2019, Elsevier.
Fig.9  Synthesis of Cy@ZIF-8 nanoparticles and their application for NIR fluorescent imaging and photothermal therapy. Reprinted with permission from ref. [103]. Copyright 2018, The Royal Society of Chemistry.
Fig.10  Schematic illustration of the one-pot synthesis of ICG@ZIF-8 nanoparticles and its application for fluorescence imaging and photothermal therapy of tumor in vivo. Reprinted with permission from ref. [108]. Copyright 2018, The Royal Society of Chemistry.
Fig.11  (a) Fabrication of ZnPc@ZIF-8. (b) TEM Image of ZnPc@ZIF-8. (c) In vitro PDT in HepG-2 cells using ZnPc@ZIF-8. Reprinted with permission from ref. [114]. Copyright 2018, American Chemical Society.
Fig.12  llustration of 1O2-based CDT that was realized by intravenous (i.v.) delivery of hybrid nanocarrier (ClO@MOF/F68) and concurrent intraperitoneal (i.p.) administration of ascorbate (Asc). Reprinted with permission from ref. [120]. Copyright 2019, John Wiley and Sons.
Fig.13  Schematic illustration of the preparation of GOx&Hb@ZIF-8. Reprinted with permission from ref. [133]. Copyright 2019, The Royal Society of Chemistry.
Fig.14  (a) The encapsulation of the Cas9/sgRNA in ZIF-8 to prepare CC-ZIFs. (b) Endosomal escape of CC-ZIFs. (c) CLSM images of cells before and after treatment with CC-ZIFs. Reprinted with permission from ref. [127]. Copyright 2018, American Chemical Society.
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