Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.
Corresponding Author(s):
KAZI Julhash U.,Email:lcb.kazi@gmail.com
引用本文:
. The mechanism of protein kinase C regulation[J]. Frontiers in Biology, 2011, 6(4): 328-336.
Julhash U. KAZI. The mechanism of protein kinase C regulation. Front Biol, 2011, 6(4): 328-336.
Chou et al., 1998; Dutil et al., 1998; Le Good et al., 1998; Cenni et al., 2002; Lee et al., 2005
AGC
PKC
PKCδ
PKC?
Rybin et al., 2003
AGC
PKC
PKC?
PKCδ
Rybin et al., 2003
AGC
PKC
PKCζ
PKCδ
Ziegler et al., 1999
Other
CK1
CK1
Rat brain PKC
Vila et al., 1989
Other
CK2
CK2
PKCβ
Tominaga et al., 1991
TK
Abl
cAbl
PKCδ
Sun et al., 2000
TK
Src
Fyn
PKCδ
Denning et al., 1996
TK
Src
Lck
PKCδ, PKCθ
Liu et al., 2000; Konishi et al., 2001
TK
Src
Lyn
PKCδ
Szallasi et al., 1995
TK
Src
Src
PKCδ, PKCi
Denning et al., 1996; Wooten et al., 2001
TK
Syk
Syk
PKCα, PKCβ1
Kawakami et al., 2003
Tab.1
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