1. 1. Department of Basic Oncology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China; 2. 2. Key Laboratory of Biodiversity and Conservation of Aquatic Organism, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
Caveolin-1 (Cav-1) isoforms, including Cav-1α and Cav-1β, were identified as integral membrane proteins and the major components of caveolae. Cav-1 proteins are highly conserved during evolution from BoldItalic to human and are capable of interacting with many signaling molecules through their caveolin scaffolding domains to regulate the activities of multiple signaling pathways. Thus, Cav-1 plays crucial roles in the regulation of cellular proliferation, differentiation and apoptosis in a cell-specific and contextual manner. In addition, Cav-1 is essential for embryonic development of vertebrates owing to its regulation of BMP, Wnt, TGF-β and other key signaling molecules. Moreover, Cav-1 is mainly expressed in terminally differentiated cells and its abnormal expression is often associated with human diseases, such as tumor progression, cardiovascular diseases, fibrosis, lung regeneration, and diseases related to virus. In this review, we will further discuss the potential of Cav-1 as a target for disease therapy and multiple drug resistance.
Corresponding Author(s):
CUI Zongbin,Email:zbcui@ihb.ac.cn
引用本文:
. New glimpses of caveolin-1 functions in embryonic development and human diseases[J]. Frontiers in Biology, 2011, 6(5): 367-376.
Saijun MO, Shengli YANG, Zongbin CUI. New glimpses of caveolin-1 functions in embryonic development and human diseases. Front Biol, 2011, 6(5): 367-376.
Stabilize CSD helical conformation Attach with membrane Interact with other protein
Le Lan et al., 2006Schlegel and Lisanti, 2000Couet et al., 1997
82-109
Nuclear magnetic resonance (NMR)
Solution of phosphatidylserine
Le Lan et al., 2006
102-134
Intramembrane region (IMR)
Plasma membrane location
Glenney and Soppet, 1992
135-150
C-attachment domain(C-MAD)
Attachment with membrane
Schlegel and Lisanti, 2000
133, 143, 156
Cysteine
Palmitoylation Interaction with other acylated protein Bind and transport cholesterol
Dietzen et al., 1995Lee et al., 2001Uittenbogaard and Smart, 2000
Tab.1
Molecules
Interact
Substrate
Regulate
Signaling pathway
Reference
Growth factor receptors
TGFR
Directly
most of TβR
Suppress
TGF-β
Razani et al., 2001a
Directly
ALK1
Promote
TGF-β
Santibanez et al., 2008
Directly
BRII
inhibit (β isoform)
BMP
Nohe et al., 2005
EGFR
Directly
EGFR
inhibit
EGF
Couet et al., 1997
Indirectly
EGFR
inhibit
EGFR-MAPK
Han et al., 2009
Directly
EGFR
promote
EGF
Agelaki et al., 2009
FGFR
Directly
Sprouty1-4
inhibit
p42/44 MAPK
Cabrita et al., 2006
Directly
IR
Active
Insulin
Nystrom et al., 1999
IR
Directly
IRS-1
active
Insulin
Chen et al., 2008
IGFR
Directly
IGF-IR
upregulate
IGF
Ravid et al., 2005
VEGFR
Directly
VEGFR-2
no action
VEGF
Labrecque et al., 2003
Directly
VEGFR-2
inhibit
p42/44 MAPK
Fang et al., 2007
Directly
Elk-1
block
VEGF
Liu et al., 1999
PDGFR
Indirectly
PDGFR
inhibit
PDGF
Tamai et al., 2001
TNFR
Directly
TRAIL
Negatively
–
Zhao et al., 2009
Directly
TRAF2
Active
–
Feng et al., 2001
Growth factors
EGF
Indirectly
EGF
Inhibit
p42/44 MAPK
Zhang et al., 2000
–
EGF
Inhibit
PI3K/Akt
Park and Han, 2009
IGF
Directly
IGF-I
Deficiency Promote
PI3K/Akt
Matthews et al., 2008
PDGF
Directly
PDGF
Inhibit
PDGF
Peterson et al., 2003
TNF
Directly
TNFa
Negative
MKK3/p38 MAPK
Wang et al., 2006
VEGF
–
VEGF
Stabilize
PI3K/Akt
Li et al., 2009
TGF
–
TGF-β1
Stabilize
PI3K/Akt
Li et al., 2009
FGF
–
FGF2
Stabilize
PI3K/Akt
Li et al., 2009
Transcriptional factors
β-catenin
Directly
β-catenin
Inhibit
Wnt
Galbiati et al., 2000
Indiirectly
Survivin
Inhibit
Wnt
Torres et al., 2006
Indiirectly
COX-2
Inhibit
Wnt
Rodriguez et al., 2009
Directly
LRP6
Active
Wnt
Yamamoto et al., 2006
NF-kB
Directly
TNFa
Negative
PI3K/PKB and p44/42 MAPK
Fakhrzadeh et al., 2008
Directly
–
Active
NF-kB
Garrean et al., 2006
p53
Directly
Mdm2
Stabilize
p53/p21(Waf1/Cip1)
Bartholomew et al., 2009
–
p53
Inhibit
–
Linge et al., 2007
Indirectly
p53
Inhibit
IGF
Ravid et al., 2005
Directly
MEK-1, ERK-2
–
p42/44 MAPK
Engelman et al., 1998a
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