Transgenic mouse models for studying adult neurogenesis

doi:10.1007/s11515-016-1405-3

Frontiers in Biology

2016, Vol. 11

Issue (3): 151-167 https://doi.org/10.1007/s11515-016-1405-3

本期目录

Transgenic mouse models for studying adult neurogenesis

Fatih Semerci^1,²,Mirjana Maletic-Savatic^1,^2,^3,^*(

)

¹. Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
². Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, Houston, TX 77030, USA
³. Department of Pediatrics-Neurology, Department of Neuroscience, and Structural and Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA

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Abstract：

The mammalian hippocampus shows a remarkable capacity for continued neurogenesis throughout life. Newborn neurons, generated by the radial neural stem cells (NSCs), are important for learning and memory as well as mood control. During aging, the number and responses of NSCs to neurogenic stimuli diminish, leading to decreased neurogenesis and age-associated cognitive decline and psychiatric disorders. Thus, adult hippocampal neurogenesis has garnered significant interest because targeting it could be a novel potential therapeutic strategy for these disorders. However, if we are to use neurogenesis to halt or reverse hippocampal-related pathology, we need to understand better the core molecular machinery that governs NSC and their progeny. In this review, we summarize a wide variety of mouse models used in adult neurogenesis field, present their advantages and disadvantages based on specificity and efficiency of labeling of different cell types, and review their contribution to our understanding of the biology and the heterogeneity of different cell types found in adult neurogenic niches.

Key words： adult neurogenesis mouse models neural stem cells neuroprogenitors lineage tracing

收稿日期: 2016-04-25 出版日期: 2016-07-05

Corresponding Author(s): Mirjana Maletic-Savatic

引用本文:

. [J]. Frontiers in Biology, 2016, 11(3): 151-167.
Fatih Semerci,Mirjana Maletic-Savatic. Transgenic mouse models for studying adult neurogenesis. Front. Biol., 2016, 11(3): 151-167.

链接本文:

https://academic.hep.com.cn/fib/CN/10.1007/s11515-016-1405-3
https://academic.hep.com.cn/fib/CN/Y2016/V11/I3/151

Fig.1

Fig.2

	Line	Use	Reference
Nestin	Nestin::lacZ	Characterization of regulatory regions of Nestin	Zimmerman et al., 1994; Johansson et al., 2002
	Nestin::CFP_nuc	Quantification of NSCs and progenitor cells	Encinas et al., 2006
	Nestin::GFP, Nestin::eGFP	Population studies of NSCs and progenitor cells	Yamaguchi et al., 2000; Kawaguchi et al., 2001; Mignone et al., 2004
	Nestin::tTA, Nestin-rtTA, Nestin-rtTA-M2-eGFPNestin-Cre, Nestin-CreER; Nestin-CreERT2	Lineage tracing	Mitsuhashi et al., 2001; Beech et al., 2004; Yu et al., 2005Betz et al., 1996; Kuo et al., 2006; Imayoshi et al., 2006; Lagace et al., 2007; Dranovsky et al., 2011
GFAP	GFAP::GFP, GFAP::eGFP GFAP::AmCyan1, AsRed2, mRFP1	Population studies of astrocytes and NSCs	Zhuo et al., 1997; Nolte et al., 2001; Hirrlinger et al., 2005; Platel et al., 2009
	GFAP::TK	Specific ablation of NSCs	Garcia et al., 2004
	GFAP-Cre, GFAP-CreERT2	Lineage tracing of NSCs	Marino et al., 2000; Casper and McCarthy, 2006; Ganat et al., 2006
Sox1	Sox1-GFP	Population studies of a subset of NSCs and ANPs	Aubert et al., 2003
	Sox1-tTA;tetO-Cre	Lineage tracing of NSCs and ANPs	Venere et al., 2012
Sox2	Sox2_β-Geo	Strong activity in SVZ but weak in SGZ	Zappone et al., 2000
	Sox2::GFP, Sox2-eGFP	Population studies of NSCs, ANPs, and astrocytes	D'Amour and Gage, 2003; Ellis et al., 2004
	Sox2::Cre, Sox2::CreER, Sox2::CreERT2	Lineage tracing	Hayashi et al., 2007; Favaro et al., 2009; Kang and Hebert, 2012
Ascl1	Ascl1-GFPnuc	Strong expression in ANPs but weak in NSCs	Leung et al., 2007
	Ascl1-CreERT2	Lineage tracing in SGZ	Kim et al., 2011
Glast	Glast::eGFP Glast::dsRed	Population studies of astrocytes and NSCs	Gong et al., 2003 Glowatzki et al., 2006; Regan et al., 2007
	Glast-CreERT2; Glast::CreERT2	Lineage tracing	Mori et al., 2006; Slezak et al., 2007
Blbp	Blbp::GFP, BLBP::eGFPBlbp::eYFP, Blbp::dsRed2Blbp::mCherry	Population studies of astrocytes and NSCs	Gong et al., 2003;Anthony et al., 2004; Schmid et al., 2006; Giachino et al., 2014
	Blbp::Cre	Lineage tracing	Anthony et al., 2004; Hegedus et al., 2007
Hes5	Hes5::GFP	Population studies of a subset of NSCs and ANPs	Basak and Taylor, 2007
	Hes5::CreERT2	Lineage tracing	Lugert et al., 2012
Tbr2	EOMES::GFP	Labeling of late ANPs and early NBs	Kwon and Hadjantonakis, 2007
	Tbr2::GFP	Labeling of late ANPs, NBs, INs and some GCs	Gong et al., 2003
	EOMES-CreERT2Tbr2::CreERT2	Lineage tracing of late ANPs and NBs	Pimeisl et al., 2013 Berg et al., 2015
Spot14	Spot14::GFP	Labeling of subset of NSCs and ANPs	Knobloch et al., 2013; Knobloch et al., 2014
	Spot14::CreERT2	Lineage tracing	Knobloch et al., 2013
Gli1	Gli1::CreERT2	Lineage tracing of NSCs in SGZ	Ahn and Joyner, 2004
Prss56	Prss56-CreERT2	Lineage tracing of NSCs in SGZ	Jourdon et al., 2015
Hopx	Hopx-3FlagGFP/+	Labeling of NSCs of SGZ	Li et al., 2015
	Hopx-ERCre/+	Lineage tracing of NSCs in SGZ	Li et al., 2015
Tctex-1	Tctex-1::GFP, Tctex-1::DsRed	Labeling of NSCs, ANPs and NBs of SGZ	Tseng et al., 2010
Pomc	Pomc::eGFP	Labeling of NBs/INs	Cowley et al., 2001
	Pomc-Cre	Lineage tracing of NBs/INs	Balthasar et al., 2004
Dcx	Dcx-eGFP Dcx-DsRed	Labeling of NBs/INs Labeling of NBs/INs	Couillard-Despres et al., 2006; Walker et al., 2007 Couillard-Despres et al., 2006; Wang et al., 2007

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