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Regulation of virus-triggered type I interferon
signaling by cellular and viral proteins |
| Bo ZHONG1,Yan-Yi WANG1,Hong-Bing SHU1, 2, |
| 1.College of Life Sciences,
Wuhan University, Wuhan 430072, China; 2.2010-03-15 9:36:38; |
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Abstract Host pattern recognition receptors (PRRs) recognize invading viral pathogens and initiate a series of signaling cascades that lead to the expression of type I interferons (IFNs) and inflammatory cytokines. During the past decade, significant progresses have been made to characterize PRRs such as Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs) and elucidate the molecular mechanisms of TLR- and RLR-mediated signaling. To avoid excessive and harmful immune effects caused by over-activation of these signaling pathways, host cells adopt a number of strategies to regulate them. In addition, invading viruses also employ a variety of mechanisms to inhibit the production of type I IFNs, thereby evading the supervision and clearance by the host. In this review, we briefly summarize the TLR- and RLR-mediated type I IFN signaling and then focus on the mechanisms by which host cellular and viral components regulate the expression of type I IFNs.
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Issue Date: 01 February 2010
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