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The Hardy-Weinberg principle and its applications
in modern population genetics |
| John J. CHEN, |
| Department of Preventive
Medicine, State University of New York at Stony Brook, Stony Brook,
NY 11794-8036, USA; |
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Abstract The discovery of the Hardy-Weinberg principle marked the beginning of the field of population genetics. Over the past hundred years, it has provided a starting point for many population genetic investigations. In this review, the Hardy-Weinberg principle, its statistical testing, and several of its applications in various modern population genetic research areas, including allelic variability and selection in the human leukocyte antigen region, microsatellite genotyping error detection, and accuracy of haplotype estimation, are discussed.
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| Keywords
the Hardy-Weinberg principle
statistical testing
population genetics
human leukocyte antigens
microsatellite genotyping
haplotype estimation
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Issue Date: 01 August 2010
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