Neural progenitor diversity and their therapeutic potential for spinal cord repair

doi:10.1007/s11515-010-0830-y

Front Biol

2010, Vol. 5

Issue (5) : 386-395 https://doi.org/10.1007/s11515-010-0830-y

REVIEW

Neural progenitor diversity and their therapeutic potential for spinal cord repair

Hedong LI¹(

), Wei SHI^1,2

1. West China Developmental & Stem Cell Institute, West China Second University Hospital, Sichuan University, Chengdu 610041, China; 2. School of Life Science, Sichuan University, Chengdu 610041, China

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Abstract

Development of the central nervous system (CNS) requires progressive differentiation of neural stem cells, which generate a variety of neural progenitors with distinct properties and differentiation potentials in a spatiotemporally restricted manner. The underlying mechanisms of neural progenitor diversification during development started to be unraveled over the past years. We have addressed these questions by v-myc immortalization method and generation of neural progenitor clones. These clones are served as in vitro models of neural differentiation and cellular tools for transplantation in animal models of neurological disorders including spinal cord injury. In this review, we will discuss features of two neural progenitor types (radial glia and GABAergic interneuron progenitor) and diversification even within each progenitor type. We will also discuss pathophysiology of spinal cord injury and our ongoing research to address both motor and sensory malfunctions by transplantation of these neural progenitors.

Keywords neural progenitors diversity radial glia interneuron progenitor spinal cord injury cell transplantation

Corresponding Author(s): LI Hedong,Email:hedongli2009@gmail.com

Issue Date: 01 October 2010

Cite this article:

Hedong LI,Wei SHI. Neural progenitor diversity and their therapeutic potential for spinal cord repair[J]. Front Biol, 2010, 5(5): 386-395.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-010-0830-y
https://academic.hep.com.cn/fib/EN/Y2010/V5/I5/386

Fig.1 : bone morphogenic proteins (BMPs) released dorsally and sonic hedgehog (SHH) released ventrally establish dorsalventral gradients in the developing cortex. Transcription factors are differentially expressed in restricted distributions in dorso-medial (e.g. Pax6) and ventro-lateral (Gsh1/2 and Olig1/2) regions of the cortex. : Expression of the glial-restricted precursor (GRP) marker 4D4 (A2B5) antigen is shown in an E12.5 rat cortical section in a graded pattern that might be under the influence of BMPs. BLBP is a radial glial marker. CTX: cortex; LGE: lateral ganglionic eminance.

Fig.2 We have applied v-myc immortalization method to generate neural progenitor clones from embryonic central nervous system (CNS), which can be expanded in culture in the presence of mitogens such as fibroblast growth factor 2 (FGF2). These clones are served as models to study neural differentiation and can be transplanted in traumatized and diseased CNS to test their therapeutic potentials. (Different colors represent different progenitor cells.)

Fig.3 : Radial glia serves as scaffolds for neuronal migration in the developing cortex. : Our hypothesis of radial glia to serve as bridges for axonal regeneration after transplantation in SCI.

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