Please wait a minute...
Frontiers in Biology

ISSN 1674-7984

ISSN 1674-7992(Online)

CN 11-5892/Q

Front Biol    2010, Vol. 5 Issue (6) : 471-472    https://doi.org/10.1007/s11515-010-1170-7
HIGHLIGHT
RNA silencing mechanisms are highly differentiated in eukaryotes
Yi ZHANG()
Center for Genome Analysis, ABLife Inc., Wuhan 430079, China
 Download: PDF(59 KB)   HTML
 Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks
Abstract

Posterior to the discovery of the double-stranded RNA mediated gene silencing two decades ago, RNA interference or RNA-mediated gene silencing has received unusual intensity of study in the biology-related research fields. RNA silencing represents a large spectrum of gene regulation mechanisms in all kingdoms of eukaryotes. The power and necessity of RNA silencing has been unambiguously appreciated in both animals and plants, although the mechanisms engaged are divergent in some aspects. Interestingly, as comprehensively reviewed by Schumann et al. in this issue, RNA silencing in the simple eukaryotic fungi strikingly differs from those of animals and plants, and among fungal species as well.

Corresponding Author(s): ZHANG Yi,Email:yizhang@whu.edu.cn   
Issue Date: 01 December 2010
 Cite this article:   
Yi ZHANG. RNA silencing mechanisms are highly differentiated in eukaryotes[J]. Front Biol, 2010, 5(6): 471-472.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-010-1170-7
https://academic.hep.com.cn/fib/EN/Y2010/V5/I6/471
1 Amaral P P, Dinger M E, Mercer T R, Mattick J S (2008). The eukaryotic genome as an RNA machine. Science , 319(5871): 1787-1789
doi: 10.1126/science.1155472 pmid:18369136
2 Davis C A, Grate L, Spingola M, Ares M Jr (2000). Test of intron predictions reveals novel splice sites, alternatively spliced mRNAs and new introns in meiotically regulated genes of yeast. Nucleic Acids Res , 28(8): 1700-1706
doi: 10.1093/nar/28.8.1700 pmid:10734188
3 Disney M D, Haidaris C G, Turner D H (2003). Uptake and antifungal activity of oligonucleotides in Candida albicans. Proc Natl Acad Sci USA , 100(4): 1530-1534
doi: 10.1073/pnas.0337462100 pmid:12552085
4 Drinnenberg I A, Weinberg D E, Xie K T, Mower J P, Wolfe K H, Fink G R, Bartel D P (2009). RNAi in budding yeast. Science , 326(5952): 544-550
doi: 10.1126/science.1176945 pmid:19745116
5 Eulalio A, Huntzinger E, Izaurralde E (2008). Getting to the root of miRNA-mediated gene silencing. Cell , 132(1): 9-14
doi: 10.1016/j.cell.2007.12.024 pmid:18191211
6 Ghildiyal M, Zamore P D (2009). Small silencing RNAs: an expanding universe. Nat Rev Genet , 10(2): 94-108
doi: 10.1038/nrg2504 pmid:19148191
7 Kedde M, Strasser M J, Boldajipour B, Oude Vrielink J A, Slanchev K, le Sage C, Nagel R, Voorhoeve P M, van Duijse J, ?rom U A, Lund A H, Perrakis A, Raz E, Agami R (2007). RNA-binding protein Dnd1 inhibits microRNA access to target mRNA. Cell , 131(7): 1273-1286
doi: 10.1016/j.cell.2007.11.034 pmid:18155131
8 Nakayashiki H (2005). RNA silencing in fungi: mechanisms and applications. FEBS Lett , 579(26): 5950-5957
doi: 10.1016/j.febslet.2005.08.016 pmid:16137680
9 Schumann U, Ayliffe M, Kazan K, Wang M B (2010). RNA silencing in fungi. Front Biol, in press
10 Whittaker R H (1969). New concepts of kingdoms or organisms. Evolutionary relations are better represented by new classifications than by the traditional two kingdoms. Science , 163(863): 150-160
doi: 10.1126/science.163.3863.150 pmid:5762760
11 Zhang L, Leibowitz M J, Zhang Y (2009). Antisense oligonucleotides effectively inhibit the co-transcriptional splicing of a Candida group I intron in vitro and in vivo: Implications for antifungal therapeutics. FEBS Lett , 583(4): 734-738
doi: 10.1016/j.febslet.2009.01.040 pmid:19185575
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed