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Frontiers in Biology

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ISSN 1674-7992(Online)

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Front Biol    2011, Vol. 6 Issue (4) : 274-281    https://doi.org/10.1007/s11515-011-1123-9
REVIEW
An overview of inflammation: mechanism and consequences
Afsar U. AHMED()
Monash University Department of Medicine, Centre for Inflammatory Diseases, Monash Medical Centre, 246, Clayton Road, Clayton, VIC 3168 Australia
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Abstract

Inflammation is an essential response provided by the immune systems that ensures the survival during infection and tissue injury. Inflammatory responses are essential for the maintenance of normal tissue homeostasis. The molecular mechanism of inflammation is quite a complicated process which is initiated by the recognition of specific molecular patterns associated with either infection or tissue injury. The entire process of the inflammatory response is mediated by several key regulators involved in the selective expression of proinflammatory molecules. Prolonged inflammations are often associated with severe detrimental side effects on health. Alterations in inflammatory responses due to persistent inducers or genetic variations are on the rise over the last couple of decades, causing a variety of inflammatory diseases and pathophysiological conditions.
Keywords Inflammation      inflammatory diseases      proinflammatory cytokines      pattern-recognition receptors      transcription factors and chromatin structure     
Corresponding Author(s): AHMED Afsar U.,Email:Afsar.Ahmed@monash.edu, afsaruahmed@gmail.com   
Issue Date: 01 August 2011
 Cite this article:   
Afsar U. AHMED. An overview of inflammation: mechanism and consequences[J]. Front Biol, 2011, 6(4): 274-281.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-011-1123-9
https://academic.hep.com.cn/fib/EN/Y2011/V6/I4/274
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