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Roles of histone ubiquitylation in DNA damage signaling |
Sui-Sui DONG, Michael S. Y. HUEN( ) |
| Genome Stability Research Laboratory, Department of Anatomy, Centre for Cancer Research, University of Hong Kong, Hong Kong, China |
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Abstract Histone ubiquitylation has emerged as an important chromatin modification associated with DNA damage signaling and repair pathways. These histone marks, laid down by E3 ubiquitin ligases that include RNF8 and RNF168, decorate chromatin domains surrounding DNA double-strand breaks (DSBs). Recent work implicated ubiquitylated histones in orchestrating cell cycle checkpoints, DNA repair and gene transcription. Here we summarize recent advances that contribute to our current knowledge of the highly dynamic nature of DSB-associated histone ubiquitylation, and discuss major challenges ahead in understanding the versatility of ubiquitin conjugation in maintaining genome stability.
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| Keywords
DNA damage
histone ubiquitylation
ubiquitin ligase
RNF8
RNF168
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Corresponding Author(s):
HUEN Michael S. Y.,Email:huen.michael@hku.hk
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Issue Date: 01 October 2011
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