|
|
Neonatal vaccination against respiratory syncytial virus infection |
Zhilong JIANG1(), Erin M. FISHER2, Jiu JIANG2 |
1. Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.; 2. Department of Biology, Drexel University, Philadelphia, PA 19104, USA |
|
|
Abstract Respiratory syncytial virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants and is the most frequent cause of lower respiratory tract infections in children. Efficacious vaccination has been a longstanding goal in neonates. Due to immaturity of the neonatal immune system, vaccination has shown limited success in stimulating the neonatal endogenous immune system. Advances in the understanding of neonatal immunology have resulted in renewed development of neonatal vaccination. In this article, we review recent advances in neonatal anti-RSV vaccination strategies, including active and passive vaccination approaches, with emphasis on the effect of maternal neutralizing antibody and the role of maternal antibody in neonatal immune modulations. Recent reports in a variety of antiviral vaccine animal models have shown that maternal antibody, different from conventional vaccination, plays an immune modulatory role in the newborn immune system. Active immunization of the pregnant mother and the offspring can effectively stimulate and maintain potent neonatal immune responses, including an endogenous cytotoxic response and neutralizing antibody generation. The induced newborn endogenous antiviral immunity can last up to 6 months, and effectively blunt viral replication. Immune complexes, formed from the integral binding of the maternal neutralizing antibody and viral vaccine antigen, may play an important role in the maternal antibody-mediated neonatal immune response. The underlying mechanisms and future perspectives are discussed.
|
Keywords
respiratory syncytial virus
vaccination
neonates
maternal antibody
immune complex
|
Corresponding Author(s):
JIANG Zhilong,Email:jiangz@mail.med.upenn.edu
|
Issue Date: 01 June 2012
|
|
1 |
Abrahamson D R, Powers A, Rodewald R (1979). Intestinal absorption of immune complexes by neonatal rats: a route of antigen transfer from mother to young. Science , 206(4418): 567-569 doi: 493961" target="_blank">10.1126/science. pmid:493961 pmid:493961
|
2 |
Adkins B, Chun K, Hamilton K, Nassiri M (1996). Naive murine neonatal T cells undergo apoptosis in response to primary stimulation. J Immunol , 157(4): 1343-1349 pmid:8759713
|
3 |
Aiuti F, Mezzaroma I (2006). Failure to reconstitute CD4+ T-cells despite suppression of HIV replication under HAART. AIDS Rev , 8(2): 88-97 pmid:16848276
|
4 |
Anderson K, Rusterholz C, M?nsson R, Jensen C T, Bacos K, Zandi S, Sasaki Y, Nerlov C, Sigvardsson M, Jacobsen S E (2007). Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes. Blood , 109(9): 3697-3705 doi: 10.1182/blood-2006-05-026021 pmid:17218387
|
5 |
Bachmann M F, Hunziker L, Zinkernagel R M, Storni T, Kopf M (2004). Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key. Eur J Immunol , 34(2): 317-326 doi: 10.1002/eji.200324717 pmid:14768036
|
6 |
Blomqvist G A, L?vgren-Bengtsson K, Morein B (2003). Influence of maternal immunity on antibody and T-cell response in mice. Vaccine , 21(17-18): 2022-2031 doi: 10.1016/S0264-410X(02)00776-4 pmid:12706692
|
7 |
Bueno S M, González P A, Cautivo K M, Mora J E, Leiva E D, Tobar H E, Fennelly G J, Eugenin E A, Jacobs W R Jr, Riedel C A, Kalergis A M (2008). Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG. Proc Natl Acad Sci USA , 105(52): 20822-20827 doi: 10.1073/pnas.0806244105 pmid:19075247
|
8 |
Buraphacheep W, Sullender W M (1997). The guinea pig as a model for the study of maternal immunization against respiratory syncytial virus infections in infancy. J Infect Dis , 175(4): 935-938 doi: 10.1086/513994 pmid:9086153
|
9 |
Cervenak J, Bender B, Schneider Z, Magna M, Carstea B V, Liliom K, Erdei A, Bosze Z, Kacskovics I (2011). Neonatal FcR overexpression boosts humoral immune response in transgenic mice. J Immunol , 186(2): 959-968 doi: 10.4049/jimmunol.1000353 pmid:21148035
|
10 |
Connors M, Collins P L, Firestone C Y, Sotnikov A V, Waitze A, Davis A R, Hung P P, Chanock R M, Murphy B R (1992). Cotton rats previously immunized with a chimeric RSV FG glycoprotein develop enhanced pulmonary pathology when infected with RSV, a phenomenon not encountered following immunization with vaccinia—RSV recombinants or RSV. Vaccine , 10(7): 475-484 doi: 10.1016/0264-410X(92)90397-3 pmid:1609551
|
11 |
Devey M E, Steward M W (1980). The induction of chronic antigen-antibody complex disease in selectively bred mice producing either high or low affinity antibody to protein antigens. Immunology , 41(2): 303-311 pmid:6449473
|
12 |
Elrefaei M, McElroy M D, Preas C P, Hoh R, Deeks S, Martin J, Cao H (2004). Central memory CD4+ T cell responses in chronic HIV infection are not restored by antiretroviral therapy. J Immunol , 173(3): 2184-2189 pmid:15265956
|
13 |
Etchart N, Baaten B, Andersen S R, Hyland L, Wong S Y, Hou S (2006). Intranasal immunisation with inactivated RSV and bacterial adjuvants induces mucosal protection and abrogates eosinophilia upon challenge. Eur J Immunol , 36(5): 1136-1144 doi: 10.1002/eji.200535493 pmid:16619288
|
14 |
Franki S N, Steward K K, Betting D J, Kafi K, Yamada R E, Timmerman J M (2007). Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo. Blood , 111(3): 1504-1511 doi: 10.1182/blood-2007-03-080507 pmid:17993615
|
15 |
Gros L, Dreja H, Fiser A L, Plays M, Pelegrin M, Piechaczyk M (2005). Induction of long-term protective antiviral endogenous immune response by short neutralizing monoclonal antibody treatment. J Virol , 79(10): 6272-6280 doi: 10.1128/JVI.79.10.6272-6280.2005 pmid:15858011
|
16 |
Gros L, Pelegrin M, Michaud H A, Bianco S, Hernandez J, Jacquet C, Piechaczyk M (2008). Endogenous cytotoxic T-cell response contributes to the long-term antiretroviral protection induced by a short period of antibody-based immunotherapy of neonatally infected mice. J Virol , 82(3): 1339-1349 doi: 10.1128/JVI.01970-07 pmid:18032505
|
17 |
Gros L, Pelegrin M, Plays M, Piechaczyk M (2006). Efficient mother-to-child transfer of antiretroviral immunity in the context of preclinical monoclonal antibody-based immunotherapy. J Virol , 80(20): 10191-10200 doi: 10.1128/JVI.01095-06 pmid:17005696
|
18 |
Haigwood N L, Montefiori D C, Sutton W F, McClure J, Watson A J, Voss G, Hirsch V M, Richardson B A, Letvin N L, Hu S L, Johnson P R (2004). Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies. J Virol , 78(11): 5983-5995 doi: 10.1128/JVI.78.11.5983-5995.2004 pmid:15140996
|
19 |
Hamano Y, Arase H, Saisho H, Saito T (2000). Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo Th cell responses. J Immunol , 164(12): 6113-6119 pmid:10843660
|
20 |
Hancock G E, Speelman D J, Heers K, Bortell E, Smith J, Cosco C (1996). Generation of atypical pulmonary inflammatory responses in BALB/c mice after immunization with the native attachment (G) glycoprotein of respiratory syncytial virus. J Virol , 70(11): 7783-7791 pmid:8892899
|
21 |
Hazenbos W L, Heijnen I A, Meyer D, Hofhuis F M, Renardel de Lavalette C R, Schmidt R E, Capel P J, van de Winkel J G, Gessner J E, van den Berg T K, Verbeek J S (1998). Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16). J Immunol , 161(6): 3026-3032 pmid:9743367
|
22 |
Hessell A J, Hangartner L, Hunter M, Havenith C E, Beurskens F J, Bakker J M, Lanigan C M, Landucci G, Forthal D N, Parren P W, Marx P A, Burton D R (2007). Fc receptor but not complement binding is important in antibody protection against HIV. Nature , 449(7158): 101-104 doi: 10.1038/nature06106 pmid:17805298
|
23 |
Heyman B (2000). Regulation of antibody responses via antibodies, complement, and Fc receptors. Annu Rev Immunol , 18(1): 709-737 doi: 10.1146/annurev.immunol.18.1.709 pmid:10837073
|
24 |
Hussell T, Baldwin C J, O’Garra A, Openshaw P J (1997). CD8+ T cells control Th2-driven pathology during pulmonary respiratory syncytial virus infection. Eur J Immunol , 27(12): 3341-3349 doi: 10.1002/eji.1830271233 pmid:9464822
|
25 |
Jakob T, Walker P S, Krieg A M, Udey M C, Vogel J C (1998). Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J Immunol , 161(6): 3042-3049 pmid:9743369
|
26 |
Kim H W, Canchola J G, Brandt C D, Pyles G, Chanock R M, Jensen K, Parrott R H (1969). Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol , 89(4): 422-434 pmid:4305198
|
27 |
Lee H H, Hoeman C M, Hardaway J C, Guloglu F B, Ellis J S, Jain R, Divekar R, Tartar D M, Haymaker C L, Zaghouani H (2008). Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity. J Exp Med , 205(10): 2269-2280 doi: 10.1084/jem.20071371 pmid:18762566
|
28 |
Lu L, Palaniyandi S, Zeng R, Bai Y, Liu X, Wang Y, Pauza C D, Roopenian D C, Zhu X (2011). A neonatal Fc receptor-targeted mucosal vaccine strategy effectively induces HIV-1 antigen-specific immunity to genital infection. J Virol , 85(20): 10542-10553 doi: 10.1128/JVI.05441-11 pmid:21849464
|
29 |
Mapletoft J W, Latimer L, Babiuk L A, van Drunen Littel-van den Hurk S (2010). Intranasal immunization of mice with a bovine respiratory syncytial virus vaccine induces superior immunity and protection compared to those by subcutaneous delivery or combinations of intranasal and subcutaneous prime-boost strategies. Clin Vaccine Immunol , 17(1): 23-35 doi: 10.1128/CVI.00250-09 pmid:19864487
|
30 |
Mejías A, Ramilo O (2008). Review of palivizumab in the prophylaxis of respiratory syncytial virus (RSV) in high-risk infants. Biologics , 2(3): 433-439 doi: 10.2147/BTT.S3104 pmid:19707374
|
31 |
Michaud H A, Gomard T, Gros L, Thiolon K, Nasser R, Jacquet C, Hernandez J, Piechaczyk M, Pelegrin M (2010). A crucial role for infected-cell/antibody immune complexes in the enhancement of endogenous antiviral immunity by short passive immunotherapy. PLoS Pathog , 6(6): e1000948 doi: 10.1371/journal.ppat.1000948 pmid:20548955
|
32 |
Mozdzanowska K, Feng J, Gerhard W (2003). Virus-neutralizing activity mediated by the Fab fragment of a hemagglutinin-specific antibody is sufficient for the resolution of influenza virus infection in SCID mice. J Virol , 77(15): 8322-8328 doi: 10.1128/JVI.77.15.8322-8328.2003 pmid:12857901
|
33 |
Pinschewer D D, Perez M, Jeetendra E, B?chi T, Horvath E, Hengartner H, Whitt M A, de la Torre J C, Zinkernagel R M (2004). Kinetics of protective antibodies are determined by the viral surface antigen. J Clin Invest , 114(7): 988-993 pmid:15467838
|
34 |
Reuman P D, Keely S P, Schiff G M, Gamble J N (1991). Similar subclass antibody responses after intranasal immunization with UV-inactivated RSV mixed with cholera toxin or live RSV. J Med Virol , 35(3): 192-197 doi: 10.1002/jmv.1890350309 pmid:1804931
|
35 |
Schuurhuis D H, van Montfoort N, Ioan-Facsinay A, Jiawan R, Camps M, Nouta J, Melief C J, Verbeek J S, Ossendorp F (2006). Immune complex-loaded dendritic cells are superior to soluble immune complexes as antitumor vaccine. J Immunol , 176(8): 4573-4580 pmid:16585547
|
36 |
Siegrist C A, Barrios C, Martinez X, Brandt C, Berney M, Córdova M, Kovarik J, Lambert P H (1998). Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime-boost strategies in mice. Eur J Immunol , 28(12): 4138-4148 doi: 10.1002/(SICI)1521-4141(199812)28:12<4138::AID-IMMU4138>3.0.CO;2-L pmid:9862350
|
37 |
Singleton R, Etchart N, Hou S, Hyland L (2003). Inability to evoke a long-lasting protective immune response to respiratory syncytial virus infection in mice correlates with ineffective nasal antibody responses. J Virol , 77(21): 11303-11311 doi: 10.1128/JVI.77.21.11303-11311.2003 pmid:14557616
|
38 |
Srikiatkhachorn A, Braciale T J (1997a). Virus-specific CD8+ T lymphocytes downregulate T helper cell type 2 cytokine secretion and pulmonary eosinophilia during experimental murine respiratory syncytial virus infection. J Exp Med , 186(3): 421-432 doi: 10.1084/jem.186.3.421 pmid:9236194
|
39 |
Srikiatkhachorn A, Braciale T J (1997b). Virus-specific memory and effector T lymphocytes exhibit different cytokine responses to antigens during experimental murine respiratory syncytial virus infection. J Virol , 71(1): 678-685 pmid:8985399
|
40 |
Victor J R, Muniz B P, Fusaro A E, de Brito C A, Taniguchi E F, Duarte A J, Sato M N (2010). Maternal immunization with ovalbumin prevents neonatal allergy development and up-regulates inhibitory receptor Fc gamma RIIB expression on B cells. BMC Immunol , 11(1): 11 doi: 10.1186/1471-2172-11-11 pmid:20222978
|
41 |
Villinger F, Mayne A E, Bostik P, Mori K, Jensen P E, Ahmed R, Ansari A A (2003). Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques. J Virol , 77(1): 10-24 doi: 10.1128/JVI.77.1.10-24.2003 pmid:12477806
|
42 |
Wu Y, Sukumar S, El Shikh M E, Best A M, Szakal A K, Tew J G (2008). Immune complex-bearing follicular dendritic cells deliver a late antigenic signal that promotes somatic hypermutation. J Immunol , 180(1): 281-290 pmid:18097029
|
43 |
Yoshida M, Claypool S M, Wagner J S, Mizoguchi E, Mizoguchi A, Roopenian D C, Lencer W I, Blumberg R S (2004). Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity , 20(6): 769-783 doi: 10.1016/j.immuni.2004.05.007 pmid:15189741
|
44 |
Zaghouani H, Hoeman C M, Adkins B (2009). Neonatal immunity: faulty T-helpers and the shortcomings of dendritic cells. Trends Immunol , 30(12): 585-591 doi: 10.1016/j.it.2009.09.002 pmid:19846341
|
45 |
Zeng R, Qi X, Gong W, Mei X, Wei L, Ma C, Yin X (2007). Long-lasting balanced immunity and protective efficacy against respiratory syncytial virus in mice induced by a recombinant protein G1F/M2. Vaccine , 25(42): 7422-7428 doi: 10.1016/j.vaccine.2007.08.007 pmid:17850930
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|