Liposome mediated drug delivery for leukocyte adhesion deficieny I (LAD I): Targeting the mutated gene <i>ITGB2</i> and expression of CD18 protein

doi:10.1007/s11515-013-1287-6

Front. Biol.

2014, Vol. 9

Issue (1) : 1-4 https://doi.org/10.1007/s11515-013-1287-6

MINI-REVIEW

Liposome mediated drug delivery for leukocyte adhesion deficieny I (LAD I): Targeting the mutated gene ITGB2 and expression of CD18 protein

C. Subathra DEVI(

), Kritika KEDARINATH, Payal CHOUDHARY, Vishakha TYAGI, Mohanasrinivasan. V

School of Biosciences and Technology, VIT University, Vellore 632014, Tamil Nadu, India

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Abstract

Leukocyte adhesion deficiency (LAD) I is a disorder caused due to mutations in a gene (ITGB2) located on chromosome 21 and encodes the β2 subunit of the leukocyte integrin molecules. This leads to defects in the adhesion of leukocytes on endothelial cells which further leads to recurrent microbial infections due to a decrease in the immune response. Base Excision Repair Mechanism (BER) is instrumental in repairing damaged DNA by removing mutated/damaged bases. We have proposed a hypothesis for the treatment of LAD I by making use of the proteins/enzyme complexes responsible for base excision repair mechanism be introduced into the leukocytes via liposomes. This will target the mutated gene in the leukocytes (mostly neutrophils) and DNA repair will occur. The liposomes can be introduced into the patients via intravenous methods.

Keywords CD18 β-integrin LAD I liposome BER ITGB2

Corresponding Author(s): C. Subathra DEVI

Issue Date: 09 October 2014

Cite this article:

C. Subathra DEVI,Kritika KEDARINATH,Payal CHOUDHARY, et al. Liposome mediated drug delivery for leukocyte adhesion deficieny I (LAD I): Targeting the mutated gene ITGB2 and expression of CD18 protein[J]. Front. Biol., 2014, 9(1): 1-4.

URL:

https://academic.hep.com.cn/fib/EN/10.1007/s11515-013-1287-6
https://academic.hep.com.cn/fib/EN/Y2014/V9/I1/1

Fig.1 BER Targeting the Mutated Gene ITGB2.

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