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Front. Biol.    2018, Vol. 13 Issue (3) : 190-196    https://doi.org/10.1007/s11515-018-1500-8
REVIEW
The effect of coagulation factors polymorphisms on abortion
Narjes Feizollahi1, Zeinab Deris Zayeri2, Najme Moradi3, Mahvash Zargar4, Hadi Rezaeeyan3()
1. Shahid Beheshti University of Medical Sciences and Health Services.Tehran,Iran
2. Golestan Hospital Clinical Research Development Unit, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3. Thalassemia & Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4. Obstetrics & Gynaecology Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
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Abstract

OBJECTIVE: Recent studies showed coagulation factors play important role in controlling pregnancy duration in addition to controlling homeostasis. Recent studies showed several polymorphisms of coagulation factors genes increase the clot formation and lead to abortion. In this study, we evaluated the polymorphisms of coagulation factors and their effects on the development of the fetus.

MATERIAL and METHODS: Relevant literature was identified by a PubMed search (1988-2017) of English language papers using the terms Abortion, pregnancy woman, coagulation factor and polymorphism.

RESULT: Several polymorphisms of coagulation factors disturb the exchange of food and other materials between the fetus and the mother, and impairs the formation of the placenta during embryonic stages.

DISCUSSION: Evaluation of functional polymorphisms in coagulation factors gene during fetal development can be used as a prognostic factor in the prevention of the abortion.
Keywords polymorphism      thrombosis      abortion      prognosis     
Corresponding Author(s): Hadi Rezaeeyan   
Online First Date: 11 July 2018    Issue Date: 31 July 2018
 Cite this article:   
Narjes Feizollahi,Zeinab Deris Zayeri,Najme Moradi, et al. The effect of coagulation factors polymorphisms on abortion[J]. Front. Biol., 2018, 13(3): 190-196.
 URL:  
https://academic.hep.com.cn/fib/EN/10.1007/s11515-018-1500-8
https://academic.hep.com.cn/fib/EN/Y2018/V13/I3/190
Gene Polymorphism Mechanism Prognosis Ref.
Thrombin
(factor II)		 20210 G>A
20209C-T		 Lead to increase level of thrombin Unfavorable Prat et al.,2014; Djurovic et al., 2017
TAFI TAFI 1040C/T Prevent of fibrinolysis Unfavorable Masini et al., 2009; ElDanasori et al.,2017
+ 505G/G Prevent of fibrinolysis Unfavorable
+ 505A/A Reduce level of TAFI Favorable
VII Arg353Gln
-122T>C		 Lead to reduce level and activity of VII factor Favorable Barlik et al., 2016
ANXA5 -302T>G Increases of coagulation generation Unfavorable Hayashi et al., 2013
TFPI T-287C Downregulates coagulation by inhibiting tissue factor-factor VIIa complex Favorable Guerra-Shinohara et al., 2012
a-fibrinogen Thr312Ala By hemorrhage, placental abruption, and thrombosis Unfavorable Kamimoto et al., 2017
Tab.1  summary of coagulation factor polymorphism in abortion
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