Based on historical documents concerning reprinted or illustrated editions of Ming-Qing popular fictions and the sequels to some of them, this article presents a study of the widespread use of typographic and lithographic printing in Shanghai between 1874 and 1911 and the dissemination of Ming-Qing popular fictions. The advent and widespread use of typographic and lithographic printing had both positive and negative effects on the dissemination of Ming-Qing popular fictions, which finalized the transformation of Chinese fiction written in the colloquial style from traditional popular fiction to new fiction or modern fiction in the late Qing period.