Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying1, WANG Dan2, WANG Xiaofeng2, JIN Jianzhong2, JIN Li2, JIAO Yi3, WEN Hao4, LIN Renyong4
1.Department of Biology, School of Environment and Chemical Engineering, Luoyang University, Luoyang 471000, China; 2.Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China; 3.Department of Biochemical and Molecular Biology, Xinjiang Medical University, Urumqi 830054, China; 4.Central Laboratory, the First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China;
Abstract：The relationship between the tenth exon C825T of G-protein β3 subunit (GNB3) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study (n = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB3 C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB3 C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups (?2 = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference (?2 = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB3 C825T polymorphism and hypertension in the Uygur population of China.
出版日期: 2007-06-05
引用本文:
. Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group[J]. Frontiers of Medicine in China, 2007, 1(2): 230-233.
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong. Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group. Front. Med., 2007, 1(2): 230-233.
