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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

邮发代号 80-967

2019 Impact Factor: 3.421

Frontiers of Medicine in China  2007, Vol. 1 Issue (4): 418-422   https://doi.org/10.1007/s11684-007-0082-7
  本期目录
Protective roles of heat stress on the neurons in hippocampal CA1 region of mice
Protective roles of heat stress on the neurons in hippocampal CA1 region of mice
WANG Chunxu1, WANG Hanxing2
1.Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 2.The Stuff Hospital of Hanfeng Plant, Handan 056200, China;
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Abstract:The effects of heat stress on the neurons in hippocampal CA1 region of brain ischemia/reperfusion were explored. The mice were pretreated with heat stress followed by ischemia/reperfusion by clipping bilateral cervical commo n arteries for 7 min. Mice were divided randomly into four groups as follows: (1) normal control group; (2) heat stress pretreated subsequent to ischemia/reperfusion group (HS/IR); (3) ischemia/reperfusion group (IR); and (4) heat stress group (HS). Animals in the last three groups were subdivided into three subgroups: 1 d, 4 d, 14 d respectively. The Morris water maze was used to test the ability of learning and memorizing, Nissl staining was used to count the average number of survived neurons in hippocampal CA1 region, and immunohistochemistry combined with image analysis system to detect the changes of Microtubule associated protein 2 (MAP-2) expression. The results showed that mice in IR group exhibited increased escape latency when compared with that of normal, HS and HS/IR groups (P<0.01), and the mice in IR group adopted an inefficient search strategy, major in circling and restricted searching manners. Nissl staining results showed a significant reduction in the number of pyramidal neurons in hippocampal CA1 regions in HS/IR and IR groups, with a decrease in IR group (P<0.01). Compared with normal group, the expression of MAP-2 in hippocampal CA1 region obviously decreased in IR group (P<0.05). The present results indicate that heat stress pretreatment can improve the spatial learning and memorizing function through protection to hippocampal neurons.
出版日期: 2007-12-05
 引用本文:   
. Protective roles of heat stress on the neurons in hippocampal CA1 region of mice[J]. Frontiers of Medicine in China, 2007, 1(4): 418-422.
WANG Chunxu, WANG Hanxing. Protective roles of heat stress on the neurons in hippocampal CA1 region of mice. Front. Med., 2007, 1(4): 418-422.
 链接本文:  
https://academic.hep.com.cn/fmd/CN/10.1007/s11684-007-0082-7
https://academic.hep.com.cn/fmd/CN/Y2007/V1/I4/418
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