Expression of heat shock protein gp96 in osteosarcoma
and its clinical significance

doi:10.1007/s11684-008-0038-6

Frontiers of Medicine in China - Selected Publications from Chinese Universities

2008, Vol. 2

Issue (2): 200-203 https://doi.org/10.1007/s11684-008-0038-6

本期目录

Expression of heat shock protein gp96 in osteosarcoma and its clinical significance

GUO Weichun¹, CHEN Anmin²

1.Department of Orthopaedics, Tongji Medical College, Huazhong University of Science & Technology；Department of Orthopaedics, Renmin Hospital of Wuhan University; 2.Department of Orthopaedics, Tongji Medical College, Huazhong University of Science & Technology;

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Abstract：This study aims to detect the expression of heat shock protein gp96 (HSPgp96) in osteosarcoma and explore its role in anti-tumor immunity. Expression of HSPgp96 in 45 cases of osteosarcoma, including 24 cases of the osteoblast type, 21 cases of chondroblast type and 5 cases of normal bone tissue were detected by immunohistochemistry (IHC). The expression rate of HSPgp96 was 100% (45/45) in osteosarcoma, compared with 20% (1/5) in normal bone tissue. The average positive cell rates were 97.23% and 0.48% in osteosarcoma and normal bone tissue, respectively, and the difference between them was significant (P < 0.01). The positive cell rates in osteoblast type and chondroblast type were 97.78% and 96.56%, respectively, and the difference had no statistical significance (P > 0.05). The expression degree of HSPgp96 in osteosarcoma had a clear correlation with the pathologic degree (P < 0.05), while it had no relationship with the clinical stage (P > 0.05). The expression of HSPgp96 is high in osteosarcoma and it may be a significant index for judgment of malignancy degree and an important target site of anti-tumor immunity.

出版日期: 2008-06-05

引用本文:

. Expression of heat shock protein gp96 in osteosarcoma and its clinical significance[J]. Frontiers of Medicine in China - Selected Publications from Chinese Universities, 2008, 2(2): 200-203.
GUO Weichun, CHEN Anmin. Expression of heat shock protein gp96 in osteosarcoma and its clinical significance. Front. Med., 2008, 2(2): 200-203.

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https://academic.hep.com.cn/fmd/CN/10.1007/s11684-008-0038-6
https://academic.hep.com.cn/fmd/CN/Y2008/V2/I2/200

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