Chunquan CAI MD, PhD1,Qingjiang ZHANG BM2,Changhong SHEN MD, PhD3,
1.Department of Neurosurgery,
General Hospital of Tianjin Medical University, Tianjin 300052, China；Department of Pediatric
Neurosurgery, Tianjin Children’s Hospital, Tianjin 300074, China; 2.Department of Pediatric
Neurosurgery, Tianjin Children’s Hospital, Tianjin 300074, China; 3.Department of Neurosurgery,
General Hospital of Tianjin Medical University, Tianjin 300052, China;
Abstract：The spinal epidural space is an uncommon presenting site in primary non-Hodgkin’s lymphomas, especially for children. A boy suffered spinal cord compression syndrome caused by primary spinal epidural non-Hodgkin’s lymphoma. Thoracolumbar magnetic resonance imaging (MRI) demonstrated an intraspinal mass. An operation was performed with gross total tumor removal. Histological examination revealed a non-Hodgkin’s B-cell lymphoma. Bone marrow aspiration was negative for lymphoma involvement. No other therapies (chemotherapy and/or radiotherapy) were performed according to the parents’ opinion. The patient died approximately one year after the operation due to brain metastases. The clinical course and imaging features were discussed with a review of literatures.
Savard M, Verreault S, Gould P V, Bernier V, Bouchard J P. Intravascular lymphoma withconus medullaris syndrome followed by encephalopathy. Can J Neurol Sci, 2008, 35(3): 366–371
Wei S H, Sheen J M, Huang C B, Hsiao C C. Primary spinalepidural non-Hodgkin's lymphoma in a child. Chang Gung Med J, 2001, 24(12): 820–825
Aznar A O, Montero M A, Rovira R, Vidal F R. Intravascularlarge B-cell lymphoma presenting with neurological syndromes: clinicopathologicstudy. Clin Neuropathol, 2007, 26(4): 180–186
Salvati M, Cervoni L, Artico M, Raco A, Ciappetta P, Delfini R. Primaryspinal epidural non-Hodgkin's lymphomas: a clinical study. Surg Neurol, 1996, 46(4): 339–343 doi: 10.1016/S0090-3019(96)00042-0
Tu C Q, Hu Y C, Rao S C, Song Y M, Li Z M. Primary Non-Hodgkin's Malignant Lymphomaof Spine. Zhongguo Jiao Xing Wai Ke ZaZhi, 1997, 4: 104–105 (in Chinese)
Boukobza M, Mazel C, Touboul E. Primary vertebral and spinal epidural non-Hodgkin's lymphomawith spinal cord compression. Neuroradiology, 1996, 38(4): 333–337 doi: 10.1007/BF00596582
Dote H, Ohta K, Nishimura R, Teramoto N, Asagi A, Nadano S, Hamada M, Yoshida I, Kobatake T, Nozaki I, Kubo Y, Tanada M, Kurita A, Takashima S. Primary extranodal non-Hodgkin'sl ymphoma of the common bile duct manifesting as obstructive jaundice:report of a case. Surg Today, 2009, 39(5): 448–451 doi: 10.1007/s00595-008-3894-4
Validire P, Capovilla M, Asselain B, Kirova Y, Goudefroye R, Plancher C, Fourquet A, Zanni M, Gaulard P, Vincent-Salomon A, Decaudin D. Primary breast non-Hodgkin's lymphoma: a large single center study of initial characteristics,natural history, and prognostic factors. Am J Hematol, 2009, 84(3): 133–139 doi: 10.1002/ajh.21353
Craig J, Walker K, Bayer L, Brunton J, Oliver B, Meiklejohn D, Kernohan N, Tauro S. Multifocal primary extranodalB-cell non-Hodgkin's lymphoma involving six extranodal sites. J Clin Pathol, 2009, 62(1): 89–91 doi: 10.1136/jcp.2008.060046
Rubinstein L J. Tumors of the lymphoreticular system. In: Atlas of Tumor Pathology, Fascicle 6. Washington, DC: Armed ForcesInstitute of Pathology, 1972, 215–234
Cayla J, Rondier J, Pradat P, Hanau J. Medullary compressionrevealing the presence of an epidural nodular lymphoma. Ann Med Interne (Paris), 1979, 130(10): 467–474
Iizuka H, Nakamura T, Kato M. Malignant lymphoma of the spinal epidural space. Reportof three cases. Neurol Med Chir (Tokyo), 1989, 29(4): 307–311 doi: 10.2176/nmc.29.307
Kishimoto K, Kitamura T, Hirayama Y, Tate G, Mitsuya T. Cytologic and immunocytochemical featuresof EBV negative primary effusion lymphoma: report on seven Japanesecases. Diagn Cytopathol, 2009, 37(4): 293–298 doi: 10.1002/dc.21022
Das D K, Al-Juwaiser A, George S S, Francis I M, Sathar S S, Sheikh Z A, Shaheen A, Pathan S K, Haji B E, George J, Kapila K. Cytomorphological and immunocytochemicalstudy of non-Hodgkin's lymphoma in pleural effusion and ascitic fluid. Cytopathology, 2007, 18(3): 157–167
Lyons M K, O'Neill B P, Kurtin P J, Marsh W R. Diagnosisand management of primary spinal epidural non-Hodgkin's lymphoma. Mayo Clin Proc, 1996, 71(5): 453–457 doi: 10.4065/71.5.453
Cai C, Shen C, Yang W, Zhang Q, Hu X. Intraspinal Neurenteric Cysts in Children. Can J Neurol Sci, 2008, 35(5): 479–486
Li M H, Holtas S, Larsson E M. MR imaging of spinal lymphoma. Acta Radiol, 1992, 33(4): 338–342 doi: 10.3109/02841859209173189
Negendank W G, al-Katib A M, Karanes C, Smith M R. Lymphomas:MR imaging contrast characteristics with clinical-pathologic correlations. Radiology, 1990, 177(1): 209–216
Zacharia T T, Law M, Naidich T P, Leeds N E. Central nervoussystem lymphoma characterization by diffusion-weighted imaging andMR spectroscopy. J Neuroimaging, 2008, 18(4): 411–417 doi: 10.1111/j.1552-6569.2007.00231.x
Thyagarajan M S, Dobson M J, Biswas A. Case report: appearance of uterine cervical lymphomaon MRI: a case report and review of the literature. Br J Radiol, 2004, 77(918): 512–515 doi: 10.1259/bjr/58044417
George J C, Caldemeyer K S, Smith R R, Czaja J T. CNS lymphomatoidgranulomatosis in AIDS: CT and MR appearances. AJR Am J Roentgenol, 1993, 161(2): 381–383
Cai C Q, Zhang Q J, Shen C H, Hu X L. Primary intraspinalprimitive neuroectodermal tumor: A case report and review of literature. J Pediatr Neurosci, 2008, 3: 154–156 doi: 10.4103/1817-1745.43647
Aabo K, Walbom-Jørgensen S. Centralnervous system complications by malignant lymphomas: radiation scheduleand treatment results. Int J Radiat OncolBiol Phys, 1986, 12(2): 197–202
