Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ? in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ? functions in vivo, and PKC ? has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ? on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ? could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ? signal pathway in the developing brain.
. The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases[J]. Frontiers of Medicine, 2011, 5(1): 70-76.
Yuan CHEN, Qi TIAN. The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases. Front Med, 2011, 5(1): 70-76.
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