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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

邮发代号 80-967

2019 Impact Factor: 3.421

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Frontiers of Medicine  2014, Vol. 8 Issue (3): 362-367   https://doi.org/10.1007/s11684-014-0363-x
  本期目录
An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine
Jian Wang1, Biyan Liang1(), Xiaoping Zhang1, Liran Xu2, Xin Deng3, Xiuhui Li4, Lu Fang5, Xinghua Tan6, Yuxiang Mao7, Guoliang Zhang8, Yuguang Wang9
1. TCM Center for AIDS Prevention and Treatment, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
3. Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China
4. Beijing You’an Hospital, Beijing 100054, China
5. Yunnan Provinical Academy of Traditional Chinese Medicine, Kunming 650031, China
6. Guangzhou Eighth People’s Hospital, Guangzhou 510060, China
7. Hebei Hospital of Traditional Chinese Medicine, Shijiazhuang 050011, China
8. Anhui Hospital of Traditional Chinese Medicine, Hefei 230000, China
9. Beijing Ditan Hospital, Beijing 100015, China
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Abstract：

This study aimed to evaluate the therapeutic effect of traditional Chinese medicine (TCM) by observing the changes in CD4 T-lymphocyte cell count of 110 cases with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) treated continuously with TCM for 84 months. Information of 110 HIV/AIDS patients from 19 provinces and cities treated with TCM from 2004 to 2013 was collected. Changes in the indexes of CD4 counts (≤200, 201–350, 351–500 and>500 cells/mm3) at five time points (0, 12, 36, 60 and 84 months) and different treatments [TCM and TCM plus antiretroviral therapy (ART)] were compared. Repeated measures test indicated no interaction between group and time (P>0.05). Degrees of increasing and decreasing CD4 count of the two groups at four different frames were statistically significant compared with the baseline. The CD4 count between the two groups was not statistically significant. For CD4 count of≤200 cells/mm3, the mean CD4 count changes were 21 and 28 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 201–350 cells/mm3, the mean CD4 count changes were 6 and 25 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of 351–500 cells/mm3, the mean CD4 count changes were −13 and −7 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. For CD4 count of>500 cells/mm3, the mean CD4 count changes were −34 and −17 cells/mm3 per year for the TCM group and TCM plus ART group, respectively. Long-term use of TCM could maintain or slow the pace of declining CD4 counts in patients with HIV/AIDS, and may achieve lasting effectiveness.
Key words： AIDS    HIV    CD4    traditional Chinese medicine    linear models
收稿日期: 2014-04-28      出版日期: 2014-10-09
Corresponding Author(s): Biyan Liang   
 引用本文:   
. [J]. Frontiers of Medicine, 2014, 8(3): 362-367.
Jian Wang, Biyan Liang, Xiaoping Zhang, Liran Xu, Xin Deng, Xiuhui Li, Lu Fang, Xinghua Tan, Yuxiang Mao, Guoliang Zhang, Yuguang Wang. An 84-month observational study of the changes in CD4 T-lymphocyte cell count of 110 HIV/AIDS patients treated with traditional Chinese medicine. Front. Med., 2014, 8(3): 362-367.
 链接本文:  
https://academic.hep.com.cn/fmd/CN/10.1007/s11684-014-0363-x
https://academic.hep.com.cn/fmd/CN/Y2014/V8/I3/362
Characteristic n (%)
Gender
Male 28 (25.45%)
Female 82 (74.55%)
Age, median years 41.48±8.13
Marriage
Married 103 (93.64%)
Unmarried 5 (4.55%)
Divorced 1 (0.91%)
Widowed 1 (0.91%)
Education
Above college 1 (0.91%)
Senior middle school 4 (3.64%)
Junior high school 62 (56.36%)
Primary school 6 (5.45%)
Preschool 37 (33.64%)
Profession
Farmer 100 (90.91%)
Unemployment 8 (7.27%)
Retirement 1 (0.91%)
Small private business 1 (0.91%)
Route of infection
Paid blood donation 92 (83.64%)
Sexual transmission 12 (10.91%)
Unknown reasons 4 (3.64%)
Intravenous drug 2(1.82%)
Had antiretroviral drugs
CD4 of≤200?cells/mm3 11 (42.31%)
CD4 of 201–350?cells/mm3 13 (29.55%)
CD4 of 351–500?cells/mm3 12 (46.15%)
CD4 of>500?cells/mm3 6 (42.86%)
Tab.1  
Time frame x ¯±s Median
0?month 317.56±167.97 298
12?months 323.89±151.24 325.5
36?months 373.13±191.97 355
60?months 341.45±180.06 331.5
84?months 363.51±179.39 343.5
Tab.2  
Time Time × group Group
CD4 count Mauchly’s W P F P F P F P
≤200?cells/mm3 0.477 0.056 14.109 0.000 0.176 0.950 0.296 0.591
201–350?cells/mm3 0.451 0.000 7.461 0.000 1.269 0.284 2.934 0.094
351–500?cells/mm3 0.711 0.572 2.563 0.043 2.837 0.028 1.035 0.319
>500?cells/mm3 0.434 0.471 5.360 0.001 0.375 0.825 0.100 0.757
Tab.3  
CD4 count (cells/mm3) Group 0 month 12 months 36 months 60 months 84 months
≤200 A(n = 15) 124.67±41.02 227.13±154.16 299.00±184.83 272.60±126.91 279.60±148.93
B(n = 11) 127.36±52.94 244.00±130.99 337.27±202.45 291.27±184.40 325.09±156.39
201–350 A(n = 31) 284.06±40.16 298.81±91.12 334.13±143.01 332.29±168.93 386.42±204.71
B(n = 13) 265.69±42.03 366.31±197.74 427.31±228.36 430.77±214.99 459.46±194.24
351–500 A(n = 14) 405.21±38.79 319.07±139.02 308.79±129.11 361.29±139.65 299.57±128.94
B(n = 12) 399.50±37.10 400.75±138.24 427.00±159.23 318.05±154.32 341.5±168.82
>500 A(n = 8) 641.83±89.78 476.17±110.14 518.83±244.36 348.87±274.50 389.17±98.30
B(n = 6) 635.38±179.71 422.38±171.92 553.50±250.21 424.75±236.80 454.63±197.66
Tab.4  
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