Peritoneal dialysis (PD) is an established form of renal replacement therapy. Long-term PD leads to morphologic and functional changes to the peritoneal membrane (PM), which is defined as peritoneal fibrosis, a known cause of loss of peritoneal ultrafiltration capacity. Inflammation and angiogenesis are key events during the pathogenesis of peritoneal fibrosis. This review discusses the pathophysiology of peritoneal fibrosis and recent research progress on key fibrogenic molecular mechanisms in peritoneal inflammation and angiogenesis, including Toll-like receptor ligand-mediated, NOD-like receptor protein 3/interleukin-1β, vascular endothelial growth factor, and angiopoietin-2/Tie2 signaling pathways. Furthermore, novel strategies targeting peritoneal inflammation and angiogenesis to preserve the PM are discussed in depth.
. [J]. Frontiers of Medicine, 2017, 11(3): 349-358.
Zhen Zhang, Na Jiang, Zhaohui Ni. Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis. Front. Med., 2017, 11(3): 349-358.
Nagy JA. Peritoneal membrane morphology and function. Kidney Int Suppl 1996; 56: S2–S11
pmid: 8914047
2
Li PK, Chow KM, Van de Luijtgaarden MW, Johnson DW , Jager KJ , Mehrotra R , Naicker S , Pecoits-Filho R , Yu XQ, Lameire N. Changes in the worldwide epidemiology of peritoneal dialysis. Nat Rev Nephrol 2017; 13(2): 90–103 https://doi.org/10.1038/nrneph.2016.181
pmid: 28029154
3
Loureiro J, Gónzalez-Mateo G, Jimenez-Heffernan J, Selgas R , López-Cabrera M , Aguilera Peralta A. Are the mesothelial-to-mesenchymal transition, sclerotic peritonitis syndromes, and encapsulating peritoneal sclerosis part of the same process? Int J Nephrol 2013; 2013: 263285 PMID: 23476771 https://doi.org/ 10.1155/2013/263285
4
Garosi G, Cappelletti F, Di Paolo N . Fibrosis and sclerosis: different disorders or different stages? Contrib Nephrol 2006; 150: 62–69 https://doi.org/10.1159/000093503
pmid: 16720993
5
Williams JD, Craig KJ, Topley N , Von Ruhland C , Fallon M , Newman GR , Mackenzie RK , Williams GT ; Peritoneal Biopsy Study Group. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol 2002; 13(2): 470–479
pmid: 11805177
6
Kaneko K, Hamada C, Tomino Y . Peritoneal fibrosis intervention. Perit Dial Int 2007; 27(Suppl 2): S82–S86
pmid: 17556336
7
Schilte MN, Celie JW, Wee PM , Beelen RH , van den Born J . Factors contributing to peritoneal tissue remodeling in peritoneal dialysis. Perit Dial Int 2009; 29(6): 605–617
pmid: 19910560
8
Baroni G, Schuinski A, de Moraes TP , Meyer F , Pecoits-Filho R . Inflammation and the peritoneal membrane: causes and impact on structure and function during peritoneal dialysis. Mediators Inflamm 2012; 2012: 912595 PMID: 22547910 https://doi.org/ 10.1155/2012/912595
9
Aroeira LS, Aguilera A, Sánchez-Tomero JA, Bajo MA , del Peso G , Jiménez-Heffernan JA , Selgas R , López-Cabrera M . Epithelial to mesenchymal transition and peritoneal membrane failure in peritoneal dialysis patients: pathologic significance and potential therapeutic interventions. J Am Soc Nephrol 2007; 18(7): 2004–2013 https://doi.org/10.1681/ASN.2006111292
pmid: 17568021
10
Bertoli SV, Barone MT, Vago L , Bonetto S , De Vecchi A , Scalamogna A , Barbiano di Belgiojoso G. Changes in peritoneal membrane after continuous ambulatory peritoneal dialysis—a histopathological study. Adv Perit Dial 1999; 15: 28–31
pmid: 10682067
Yung S, Chan TM. Intrinsic cells: mesothelial cells—central players in regulating inflammation and resolution. Perit Dial Int 2009; 29(Suppl 2): S21–S27
pmid: 19270220
13
Topley N, Jörres A, Luttmann W , Petersen MM , Lang MJ , Thierauch KH , Müller C , Coles GA , Davies M , Williams JD . Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1β and TNFα. Kidney Int 1993; 43(1): 226–233 https://doi.org/10.1038/ki.1993.36
pmid: 8433563
14
Kato S, Yuzawa Y, Tsuboi N , Maruyama S , Morita Y , Matsuguchi T , Matsuo S . Endotoxin-induced chemokine expression in murine peritoneal mesothelial cells: the role of toll-like receptor 4. J Am Soc Nephrol 2004; 15(5): 1289–1299
pmid: 15100369
15
López-Cabrera M. Mesenchymal conversion of mesothelial cells is a key event in the pathophysiology of the peritoneum during peritoneal dialysis. Adv Med 2014; 2014: 473134 doi: 10.1155/2014/473134
16
Di Paolo N, Sacchi G. Atlas of peritoneal histology. Perit Dial Int 2000; 20(Suppl 3): S5–S96
pmid: 10877488
17
Boulanger E, Wautier MP, Wautier JL , Boval B , Panis Y , Wernert N , Danze PM , Dequiedt P . AGEs bind to mesothelial cells via RAGE and stimulate VCAM-1 expression. Kidney Int 2002; 61(1): 148–156 https://doi.org/10.1046/j.1523-1755.2002.00115.x
pmid: 11786095
18
De Vriese AS. The John F. Maher Recipient Lecture 2004: rage in the peritoneum. Perit Dial Int 2005; 25(1): 8–11
pmid: 15770917
19
Jiang N, Zhang Z, Fang W , Qian J, Mou S, Ni Z . High peritoneal glucose exposure is associated with increased incidence of relapsing and recurrent bacterial peritonitis in patients undergoing peritoneal dialysis. Blood Purif 2015; 40(1): 72–78 https://doi.org/10.1159/000381663
pmid: 26138314
20
Yang X, Lin A, Jiang N , Yan H, Ni Z, Qian J , Fang W. Interleukin-6 trans-signalling induces vascular endothelial growth factor synthesis partly via Janus kinases-STAT3 pathway in human mesothelial cells. Nephrology (Carlton) 2017; 22(2): 150–158 https://doi.org/10.1111/nep.12746
pmid: 26869278
21
Yang X, Zhang H, Hang Y , Yan H, Lin A, Huang J , Ni Z, Qian J, Fang W . Intraperitoneal interleukin-6 levels predict peritoneal solute transport rate: a prospective cohort study. Am J Nephrol 2014; 39(6): 459–465 https://doi.org/10.1159/000362622
pmid: 24854010
22
Ding L, Shao X, Cao L , Fang W, Yan H, Huang J , Gu A, Yu Z, Qi C , Chang X , Ni Z. Possible role of IL-6 and TIE2 gene polymorphisms in predicting the initial high transport status in patients with peritoneal dialysis: an observational study. BMJ Open 2016; 6(10): e012967 https://doi.org/10.1136/bmjopen-2016-012967
pmid: 27798027
23
Feurino LW, Zhang Y, Bharadwaj U , Zhang R , Li F, Fisher WE, Brunicardi FC , Chen C, Yao Q, Min L . IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells. Cancer Biol Ther 2007; 6(7): 1096–1100 https://doi.org/10.4161/cbt.6.7.4328
pmid: 17568185
24
Park JH, Kim YG, Shaw M , Kanneganti TD , Fujimoto Y , Fukase K , Inohara N , Núñez G . Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J Immunol 2007; 179(1): 514–521 https://doi.org/10.4049/jimmunol.179.1.514
pmid: 17579072
25
Lai KN, Tang SC, Leung JC . Mediators of inflammation and fibrosis. Perit Dial Int 2007; 27(Suppl 2): S65–S71
pmid: 17556333
26
Colmont CS, Raby AC, Dioszeghy V , Lebouder E , Foster TL , Jones SA , Labéta MO , Fielding CA , Topley N . Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrol Dial Transplant 2011; 26(12): 4079–4090 https://doi.org/10.1093/ndt/gfr217
pmid: 21633096
Achek A, Yesudhas D, Choi S . Toll-like receptors: promising therapeutic targets for inflammatory diseases. Arch Pharm Res 2016; 39(8): 1032–1049 https://doi.org/10.1007/s12272-016-0806-9
pmid: 27515048
29
Strippoli R, Benedicto I, Pérez Lozano ML, Cerezo A , López-Cabrera M , del Pozo MA . Epithelial-to-mesenchymal transition of peritoneal mesothelial cells is regulated by an ERK/NF-κB/Snail1 pathway. Dis Model Mech 2008; 1(4-5): 264–274 doi:10.1242/dmm.001321
pmid: 19093035
Strippoli R, Benedicto I, Foronda M , Perez-Lozano ML , Sánchez-Perales S , López-Cabrera M , Del Pozo MÁ . p38 maintains E-cadherin expression by modulating TAK1-NF-κB during epithelial-to-mesenchymal transition. J Cell Sci 2010; 123(24): 4321–4331 https://doi.org/10.1242/jcs.071647
pmid: 21098640
32
Zhou Q, Yang M, Lan H , Yu X. miR-30a negatively regulates TGF- b1-induced epithelial-mesenchymal transition and peritoneal fibrosis by targeting Snai1. Am J Pathol 2013; 183(3): 808–819 https://doi.org/10.1016/j.ajpath.2013.05.019
pmid: 23831330
33
Zhang K, Zhang H, Zhou X , Tang WB , Xiao L, Liu YH, Liu H , Peng YM , Sun L, Liu FY. miRNA 589 regulates epithelial mesenchymal transition in human peritoneal mesothelial cells. J Biomed Biotechnol 2012; 2012: 673096 https://doi.org/ 10.1155/2012/673096
34
Liu Q, Mao H, Nie J , Chen W, Yang Q, Dong X , Yu X. Transforming growth factor β1 induces epithelial-mesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells. Perit Dial Int 2008; 28(Suppl 3): S88–S95
pmid: 18552272
35
Shen J, Wang L, Jiang N , Mou S, Zhang M, Gu L , Shao X, Wang Q, Qi C , Li S, Wang W, Che X , Ni Z. NLRP3 inflammasome mediates contrast media-induced acute kidney injury by regulating cell apoptosis. Sci Rep 2016; 6(1): 34682 https://doi.org/10.1038/srep34682
pmid: 27721494
36
Hautem N, Morelle J, Sow A , Corbet C , Feron O , Goffin E , Huaux F , Devuyst O. The NLRP3 inflammasome has a critical role in peritoneal dialysis-related peritonitis. J Am Soc Nephrol 2017; 28(7):2038–2052. PMID: 28193826 https://doi.org/ 10.1681/ASN.2016070729
37
Yáñez-Mó M , Lara-Pezzi E , Selgas R , Ramírez-Huesca M , Domínguez-Jiménez C, Jiménez-Heffernan JA, Aguilera A , Sánchez-Tomero JA , Bajo MA , Alvarez V , Castro MA , del Peso G , Cirujeda A , Gamallo C , Sánchez-Madrid F , López-Cabrera M . Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med 2003; 348(5): 403–413 https://doi.org/10.1056/NEJMoa020809
pmid: 12556543
38
Strippoli R, Moreno-Vicente R, Battistelli C , Cicchini C , Noce V, Amicone L, Marchetti A , Del Pozo MA , Tripodi M . Molecular mechanisms underlying peritoneal EMT and fibrosis. Stem Cells Int 2016; 2016: 3543678 https://doi.org/ 10.1155/2016/3543678
39
Wu J, Li X, Zhu G , Zhang Y , He M, Zhang J. The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS. Exp Cell Res 2016; 341(1): 42–53 https://doi.org/10.1016/j.yexcr.2016.01.014
pmid: 26825654
40
Yuan J, Fang W, Ni Z , Dai H, Lin A, Cao L , Qian J. Peritoneal morphologic changes in a peritoneal dialysis rat model correlate with angiopoietin/Tie-2. Pediatr Nephrol 2009; 24(1): 163–170 https://doi.org/10.1007/s00467-008-0944-5
pmid: 18751736
41
Zweers MM, Struijk DG, Smit W , Krediet RT . Vascular endothelial growth factor in peritoneal dialysis: a longitudinal follow-up. J Lab Clin Med 2001; 137(2): 125–132 https://doi.org/10.1067/mlc.2001.112235
pmid: 11174469
42
Mortier S, Faict D, Lameire NH , De Vriese AS . Benefits of switching from a conventional to a low-GDP bicarbonate/lactate-buffered dialysis solution in a rat model. Kidney Int 2005; 67(4): 1559–1565 https://doi.org/10.1111/j.1523-1755.2005.00237.x
pmid: 15780112
43
Stavenuiter AW, Schilte MN, Ter Wee PM , Beelen RH . Angiogenesis in peritoneal dialysis. Kidney Blood Press Res 2011; 34(4): 245–252 https://doi.org/10.1159/000326953
pmid: 21691127
44
Niu J, Azfer A, Zhelyabovska O , Fatma S , Kolattukudy PE . Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP). J Biol Chem 2008; 283(21): 14542–14551 https://doi.org/10.1074/jbc.M802139200
pmid: 18364357
45
Margetts PJ, Kolb M, Yu L , Hoff CM , Holmes CJ , Anthony DC , Gauldie J . Inflammatory cytokines, angiogenesis, and fibrosis in the rat peritoneum. Am J Pathol 2002; 160(6): 2285–2294 https://doi.org/10.1016/S0002-9440(10)61176-5
pmid: 12057931
46
Rosell A, Arai K, Lok J , He T, Guo S, Navarro M , Montaner J , Katusic ZS , Lo EH. Interleukin-1β augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab 2009; 29(5): 933–943 PMID:19240740 https://doi.org/10.1038/jcbfm.2009.17
47
Catar R, Witowski J, Zhu N , Lücht C , Derrac Soria A , Uceda Fernandez J , Chen L, Jones SA, Fielding CA , Rudolf A , Topley N , Dragun D , Jörres A . IL-6 trans-signaling links inflammation with angiogenesis in the peritoneal membrane. J Am Soc Nephrol 2017; 28(4): 1188–1199 https://doi.org/10.1681/ASN.2015101169
pmid: 27837150
48
Fan Y, Ye J, Shen F , Zhu Y, Yeghiazarians Y, Zhu W , Chen Y, Lawton MT, Young WL , Yang GY . Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. J Cereb Blood Flow Metab 2008; 28(1): 90–98 https://doi.org/10.1038/sj.jcbfm.9600509
pmid: 17519976
49
Li A, Dubey S, Varney ML , Dave BJ , Singh RK . IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 2003; 170(6): 3369–3376 https://doi.org/10.4049/jimmunol.170.6.3369
pmid: 12626597
50
Leibovich SJ, Polverini PJ, Shepard HM , Wiseman DM , Shively V , Nuseir N . Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α. Nature 1987; 329(6140): 630–632 https://doi.org/10.1038/329630a0
pmid: 2443857
51
De Vriese AS, Tilton RG, Stephan CC , Lameire NH . Vascular endothelial growth factor is essential for hyperglycemia-induced structural and functional alterations of the peritoneal membrane. J Am Soc Nephrol 2001; 12(8): 1734–1741
pmid: 11461947
52
Neufeld G, Cohen T, Gengrinovitch S , Poltorak Z . Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999; 13(1): 9–22
pmid: 9872925
53
Roskoski R Jr . Vascular endothelial growth factor (VEGF) and VEGF receptor inhibitors in the treatment of renal cell carcinomas. Pharmacol Res 2017; 120: 116–132 https://doi.org/10.1016/j.phrs.2017.03.010
pmid: 28330784
54
González-Mateo GT , Aguirre AR , Loureiro J , Abensur H , Sandoval P , Sánchez-Tomero JA , delPeso G , Jiménez-Heffernan JA , Ruiz-Carpio V , Selgas R , López-Cabrera M , Aguilera A , Liappas G . Rapamycin protects from type I peritoneal membrane failure inhibiting the angiogenesis, lymphangiogenesis, and Endo-MT. Biomed Res Int 2015; 2015: 989560 doi: 10.1155/2015/989560
Aroeira LS, Lara-Pezzi E, Loureiro J , Aguilera A , Ramírez-Huesca M , González-Mateo G , Pérez-Lozano ML , Albar-Vizcaíno P , Bajo MA , del Peso G , Sánchez-Tomero JA , Jiménez-Heffernan JA , Selgas R , López-Cabrera M . Cyclooxygenase-2 mediates dialysate-induced alterations of the peritoneal membrane. J Am Soc Nephrol 2009; 20(3): 582–592 https://doi.org/10.1681/ASN.2008020211
pmid: 19158357
57
Maisonpierre PC, Suri C, Jones PF , Bartunkova S , Wiegand SJ , Radziejewski C , Compton D , McClain J , Aldrich TH , Papadopoulos N , Daly TJ , Davis S , Sato TN , Yancopoulos GD . Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277(5322): 55–60 https://doi.org/10.1126/science.277.5322.55
pmid: 9204896
58
Kim M, Allen B, Korhonen EA , Nitschké M , Yang HW , Baluk P , Saharinen P , Alitalo K , Daly C, Thurston G, McDonald DM . Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest 2016; 126(9): 3511–3525 https://doi.org/10.1172/JCI84871
pmid: 27548529
Korhonen EA, Lampinen A, Giri H , Anisimov A , Kim M, Allen B, Fang S , D’Amico G , Sipilä TJ , Lohela M , Strandin T , Vaheri A , Ylä-Herttuala S , Koh GY, McDonald DM, Alitalo K , Saharinen P . Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest 2016; 126(9): 3495–3510 https://doi.org/10.1172/JCI84923
pmid: 27548530
Fukuhara S, Sako K, Minami T , Noda K, Kim HZ, Kodama T , Shibuya M , Takakura N , Koh GY, Mochizuki N. Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol 2008; 10(5): 513–526 https://doi.org/10.1038/ncb1714
pmid: 18425120
64
Yuan J, Fang W, Lin A , Ni Z, Qian J. Angiopoietin-2/Tie2 signaling involved in TNF- a induced peritoneal angiogenesis. Int J Artif Organs 2012; 35(9): 655–662
pmid: 23065888
65
Zareie M, Hekking LH, Welten AG , Driesprong BA , Schadee-Eestermans IL , Faict D , Leyssens A , Schalkwijk CG , Beelen RH , ter Wee PM , van den Born J . Contribution of lactate buffer, glucose and glucose degradation products to peritoneal injury in vivo. Nephrol Dial Transplant 2003; 18(12): 2629–2637 https://doi.org/10.1093/ndt/gfg356
pmid: 14605288
66
Xiao J, Guo J, Liu XX , Zhang XX , Li ZZ, Zhao ZZ, Liu ZS . Soluble Tie2 fusion protein decreases peritoneal angiogenesis in uremic rats. Mol Med Rep 2013; 8(1): 267–271
pmid: 23685484
67
David S, John SG, Jefferies HJ , Sigrist MK , Kümpers P , Kielstein JT , Haller H , McIntyre CW . Angiopoietin-2 levels predict mortality in CKD patients. Nephrol Dial Transplant 2012; 27(5): 1867–1872 https://doi.org/10.1093/ndt/gfr551
pmid: 21976741
68
Raby AC, Colmont CS, Kift-Morgan A , Köhl J , Eberl M , Fraser D , Topley N , Labéta MO . Toll-like receptors 2 and 4 are potential therapeutic targets in peritoneal dialysis-associated fibrosis. J Am Soc Nephrol 2017; 28(2): 461–478 https://doi.org/10.1681/ASN.2015080923
pmid: 27432741
69
Achek A, Yesudhas D, Choi S . Toll-like receptors: promising therapeutic targets for inflammatory diseases. Arch Pharm Res 2016; 39(8): 1032–1049 https://doi.org/10.1007/s12272-016-0806-9
pmid: 27515048
70
Kushiyama T, Oda T, Yamada M , Higashi K , Yamamoto K , Oshima N , Sakurai Y , Miura S , Kumagai H . Effects of liposome-encapsulated clodronate on chlorhexidine gluconate-induced peritoneal fibrosis in rats. Nephrol Dial Transplant 2011; 26(10): 3143–3154 https://doi.org/10.1093/ndt/gfr068
pmid: 21362737
Qayyum A, Oei EL, Paudel K , Fan SL. Increasing the use of biocompatible, glucose-free peritoneal dialysis solutions. World J Nephrol 2015; 4(1): 92–97 https://doi.org/10.5527/wjn.v4.i1.92
pmid: 25664250
73
Pecoits-Filho R, Araújo MR, Lindholm B , Stenvinkel P , Abensur H , Romão JE Jr , Marcondes M , De Oliveira AH , Noronha IL . Plasma and dialysate IL-6 and VEGF concentrations are associated with high peritoneal solute transport rate. Nephrol Dial Transplant 2002; 17(8): 1480–1486 https://doi.org/10.1093/ndt/17.8.1480
pmid: 12147798
74
Ferrantelli E, Liappas G, Vila Cuenca M , Keuning ED , Foster TL , Vervloet MG , Lopéz-Cabrera M , Beelen RH . The dipeptide alanyl-glutamine ameliorates peritoneal fibrosis and attenuates IL-17 dependent pathways during peritoneal dialysis. Kidney Int 2016; 89(3): 625–635 https://doi.org/10.1016/j.kint.2015.12.005
pmid: 26880457
75
Bozkurt D, Sipahi S, Cetin P , Hur E, Ozdemir O, Ertilav M , Sen S, Duman S. Does immunosuppressive treatment ameliorate morphology changes in encapsulating peritoneal sclerosis? Perit Dial Int 2009; 29(Suppl 2): S206–S210
pmid: 19270219
76
Hur E, Bozkurt D, Timur O , Bicak S , Sarsik B , Akcicek F , Duman S . The effects of mycophenolate mofetil on encapsulated peritoneal sclerosis model in rats. Clin Nephrol 2012; 77(1): 1–7 https://doi.org/10.5414/CN107140
pmid: 22185962
77
Takahashi S, Taniguchi Y, Nakashima A , Arakawa T , Kawai T , Doi S, Ito T, Masaki T , Kohno N , Yorioka N . Mizoribine suppresses the progression of experimental peritoneal fibrosis in a rat model. Nephron, Exp Nephrol 2009; 112(2): e59–e69 https://doi.org/10.1159/000213896
pmid: 19390220
78
Tapiawala SN, Bargman JM, Oreopoulos DG , Simons M . Prolonged use of the tyrosine kinase inhibitor in a peritoneal dialysis patient with metastatic renal cell carcinoma: possible beneficial effects on peritoneal membrane and peritonitis rates. Int Urol Nephrol 2009; 41(2): 431–434 https://doi.org/10.1007/s11255-009-9545-x
pmid: 19255867
79
Bozkurt D, Sarsik B, Hur E , Ertilav M , Karaca B , Timur O , Bicak S , Akcicek F , Duman S . A novel angiogenesis inhibitor, sunitinib malate, in encapsulating peritoneal sclerosis. J Nephrol 2011; 24(3): 359–365 https://doi.org/10.5301/JN.2011.6257
pmid: 21240876
80
Loureiro J, Schilte M, Aguilera A , Albar-Vizcaíno P , Ramírez-Huesca M , Pérez-Lozano ML , González-Mateo G , Aroeira LS , Selgas R , Mendoza L , Ortiz A , Ruíz-Ortega M , van den Born J , Beelen RH , López-Cabrera M . BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure. Nephrol Dial Transplant 2010; 25(4): 1098–1108 https://doi.org/10.1093/ndt/gfp618
pmid: 20067910
81
Peng W, Dou X, Hao W , Zhou Q, Tang R, Nie J , Lan HY, Yu X. Smad7 gene transfer attenuates angiogenesis in peritoneal dialysis rats. Nephrology (Carlton) 2013; 18(2): 138–147 https://doi.org/10.1111/nep.12017
pmid: 23217002
82
Fabbrini P, Schilte MN, Zareie M , ter Wee PM , Keuning ED , Beelen RH , van den Born J . Celecoxib treatment reduces peritoneal fibrosis and angiogenesis and prevents ultrafiltration failure in experimental peritoneal dialysis. Nephrol Dial Transplant 2009; 24(12): 3669–3676 https://doi.org/10.1093/ndt/gfp384
pmid: 19666665
83
Yoshio Y, Miyazaki M, Abe K , Nishino T , Furusu A , Mizuta Y , Harada T , Ozono Y , Koji T, Kohno S. TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental model. Kidney Int 2004; 66(4): 1677–1685 https://doi.org/10.1111/j.1523-1755.2004.00935.x
pmid: 15458466
84
Hekking LH, Zareie M, Driesprong BA , Faict D , Welten AG , de Greeuw I , Schadee-Eestermans IL , Havenith CE , van den Born J , ter Wee PM , Beelen RH . Better preservation of peritoneal morphologic features and defense in rats after long-term exposure to a bicarbonate/lactate-buffered solution. J Am Soc Nephrol 2001; 12(12): 2775–2786
pmid: 11729248
85
Johnson DW, Brown FG, Clarke M , Boudville N , Elias TJ , Foo MW, Jones B, Kulkarni H , Langham R , Ranganathan D , Schollum J , Suranyi MG , Tan SH, Voss D; balANZ Trial Investigators. The effect of low glucose degradation product, neutral pH versus standard peritoneal dialysis solutions on peritoneal membrane function: the balANZ trial. Nephrol Dial Transplant 2012; 27(12): 4445–4453 https://doi.org/10.1093/ndt/gfs314
pmid: 22859794
86
Seo EY, An SH, Cho JH , Suh HS, Park SH, Gwak H , Kim YL, Ha H. Effect of biocompatible peritoneal dialysis solution on residual renal function: a systematic review of randomized controlled trials. Perit Dial Int 2014; 34(7): 724–731 https://doi.org/10.3747/pdi.2012.00331
pmid: 25185015
87
Lin A, Qian J, Li X , Yu X, Liu W, Sun Y , Chen N, Mei C; Icodextrin National Multi-center Cooperation Group.Randomized controlled trial of icodextrin versus glucose containing peritoneal dialysis fluid. Clin J Am Soc Nephrol 2009; 4(11): 1799–1804 https://doi.org/10.2215/CJN.02950509
pmid: 19808224
88
Takatori Y, Akagi S, Sugiyama H , Inoue J , Kojo S, Morinaga H, Nakao K , Wada J, Makino H. Icodextrin increases technique survival rate in peritoneal dialysis patients with diabetic nephropathy by improving body fluid management: a randomized controlled trial. Clin J Am Soc Nephrol 2011; 6(6): 1337–1344 https://doi.org/10.2215/CJN.10041110
pmid: 21493740
89
le Poole CY, Welten AG, Weijmer MC , Valentijn RM , van Ittersum FJ , ter Wee PM . Initiating CAPD with a regimen low in glucose and glucose degradation products, with icodextrin and amino acids (NEPP) is safe and efficacious. Perit Dial Int 2005; 25(Suppl 3): S64–S68
pmid: 16048260
90
del Peso G, Jiménez-Heffernan JA, Selgas R , Remón C , Ossorio M , Fernández-Perpén A, Sánchez-Tomero JA, Cirugeda A , de Sousa E , Sandoval P , Díaz R , López-Cabrera M , Bajo MA . Biocompatible dialysis solutions preserve peritoneal mesothelial cell and vessel wall integrity. a case-control study on human biopsies. Perit Dial Int 2016; 36(2): 129–134 https://doi.org/10.3747/pdi.2014.00038
pmid: 26475848
91
Washida N, Wakino S, Tonozuka Y , Homma K , Tokuyama H , Hara Y, Hasegawa K, Minakuchi H , Fujimura K , Hosoya K , Hayashi K , Itoh H. Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis. Nephrol Dial Transplant 2011; 26(9): 2770–2779 https://doi.org/10.1093/ndt/gfr012
pmid: 21378147
92
Peng W, Zhou Q, Ao X , Tang R, Xiao Z. Inhibition of Rho-kinase alleviates peritoneal fibrosis and angiogenesis in a rat model of peritoneal dialysis. Ren Fail 2013; 35(7): 958–966 https://doi.org/10.3109/0886022X.2013.808565
pmid: 23859538
93
Tanabe K, Maeshima Y, Ichinose K , Kitayama H , Takazawa Y , Hirokoshi K , Kinomura M , Sugiyama H , Makino H . Endostatin peptide, an inhibitor of angiogenesis, prevents the progression of peritoneal sclerosis in a mouse experimental model. Kidney Int 2007; 71(3): 227–238 https://doi.org/10.1038/sj.ki.5002040
pmid: 17191085
94
Busnadiego O, Loureiro-Álvarez J, Sandoval P , Lagares D , Dotor J , Pérez-Lozano ML , López-Armada MJ , Lamas S , López-Cabrera M , Rodríguez-Pascual F . A pathogenetic role for endothelin-1 in peritoneal dialysis-associated fibrosis. J Am Soc Nephrol 2015; 26(1): 173–182 https://doi.org/10.1681/ASN.2013070799
pmid: 25012164
95
Pletinck A, Van Landschoot M, Steppan S , Laukens D , Passlick-Deetjen J , Vanholder R , Van Biesen W . Oral supplementation with sulodexide inhibits neo-angiogenesis in a rat model of peritoneal perfusion. Nephrol Dial Transplant 2012; 27(2): 548–556 https://doi.org/10.1093/ndt/gfr370
pmid: 21750165