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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

邮发代号 80-967

2019 Impact Factor: 3.421

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Frontiers of Medicine  2019, Vol. 13 Issue (1): 121-125   https://doi.org/10.1007/s11684-018-0615-2
  本期目录
Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis
Jing Yue1, Bo Zhang1, Mingyue Wang1, Junning Yao1, Yifan Zhou1, Ding Ma2, Lei Jin1()
1. Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2. Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract：

This retrospective study aims to demonstrate the effect of antitubercular treatment (ATT) on the pregnancy outcomes and prognoses of patients with genital tuberculosis (GTB) who had received laparoscopy and/or hysteroscopy. This study included 78 patients with infertility and who were diagnosed with GTB through laparoscopy and/or hysteroscopy over the period of November 2005 to October 2015. The recruited patients were divided into ATT and nonATT groups on the basis of ATT duration. The GTB recurrence rates, menstrual patterns, and pregnancy outcomes of the patients were determined at follow-up. Among the 78 patients, 46 received ATT and 32 did not receive ATT. The menstrual volumes of patients in the ATT group significantly decreased relative to those of patients in the nonATT group. GTB did not recur among all patients regardless of treatment. A total of 11 pregnancies (36.7%) in the ATT group and 19 pregnancies (63.3%) in the nonATT group were observed. Pregnancy rates significantly differed (P = 0.002) between the two groups. ATT may decrease the menstrual volume and pregnancy rates of patients who were diagnosed with GTB through laparoscopy and/or hysteroscopy. In addition, ATT did not improve the prognosis of patients with chronic GTB.
Key words： antitubercular treatment    pregnancy    prognosis    genital tuberculosis
收稿日期: 2016-11-15      出版日期: 2019-03-12
Corresponding Author(s): Lei Jin   
 引用本文:   
. [J]. Frontiers of Medicine, 2019, 13(1): 121-125.
Jing Yue, Bo Zhang, Mingyue Wang, Junning Yao, Yifan Zhou, Ding Ma, Lei Jin. Effect of antitubercular treatment on the pregnancy outcomes and prognoses of patients with genital tuberculosis. Front. Med., 2019, 13(1): 121-125.
 链接本文:  
https://academic.hep.com.cn/fmd/CN/10.1007/s11684-018-0615-2
https://academic.hep.com.cn/fmd/CN/Y2019/V13/I1/121
Total ATT NonATT P value
No. % No. %
Total 78 46 59.0 32 41.0
Age (year) 0.515
<30 55 32 58.2 23 41.8
≥30 23 14 60.9 9 39.1
Infertility 0.669
Primary 73 43 58.9 30 41.1
Secondary 5 3 60.0 2 40.0
Endometrial biopsy 0.598
TB-positive 22 13 59.1 9 40.9
TB-negative 56 33 58.9 23 41.1
Hydrosalpinx 0.696
Yes 32 19 59.4 13 40.6
No 46 27 57.8 19 42.2
Salpingectomy 0.914
Bilateral 33 20 60.6 13 39.4
Unilateral 13 7 53.8 6 46.2
None 32 19 59.4 13 40.6
Pelvic adhesions 0.682
Yes 76 45 58.7 31 41.3
No 2 1 50.0 1 50.0
Chest X-ray 0.074
Positive 28 13 46.4 15 53.6
Negative 50 33 66.0 17 34.0
Tab.1  
Before ATT After ATT
ATT NonATT P value ATT NonATT P value
Menstrual volume 0.447 0.007*
Normal 37 27 24 26
Less 9 5 22 6
Menstrual period 0.114 0.192
Regular 42 32 43 33
Non-regular 4 0 2 0
Tab.2  
No. ATT NonATT P value
Total 78 46 32
Recurrence
Yes 0 0 (0.0%) 0 (0.0%) a
No 78 46 (100.0%) 32 (100.0%)
Pregnant outcome 0.002*
Pregnancy 30 11 (36.7%) 19 (63.3%)
Nonpregnancy 48 35 (72.9%) 13 (27.1%)
Tab.3  
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