Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

doi:10.1007/s11684-018-0655-7

Frontiers of Medicine

2018, Vol. 12

Issue (6): 697-706 https://doi.org/10.1007/s11684-018-0655-7

本期目录

Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway

Jun Song^1,^2,³, Yeping Huang¹, Wenjian Zheng⁴, Jing Yan¹, Min Cheng⁵, Ruxing Zhao², Li Chen², Cheng Hu¹(

), Weiping Jia¹(

)

¹. Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Diseases, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China
². Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China
³. Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
⁴. Department of Geriatrics, Qingdao Haici Medical Treatment Group, Qingdao 266000, China
⁵. Huangdao Disease Prevention and Control Center, Qingdao 266555, China

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Abstract：

Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms. We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells. Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROS reduction. Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Thus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection in metabolic syndrome.

Key words： resveratrol reactive oxygen species AMPK mTOR autophagy

收稿日期: 2017-06-14 出版日期: 2018-12-03

Corresponding Author(s): Cheng Hu,Weiping Jia

引用本文:

. [J]. Frontiers of Medicine, 2018, 12(6): 697-706.
Jun Song, Yeping Huang, Wenjian Zheng, Jing Yan, Min Cheng, Ruxing Zhao, Li Chen, Cheng Hu, Weiping Jia. Resveratrol reduces intracellular reactive oxygen species levels by inducing autophagy through the AMPK-mTOR pathway. Front. Med., 2018, 12(6): 697-706.

链接本文:

https://academic.hep.com.cn/fmd/CN/10.1007/s11684-018-0655-7
https://academic.hep.com.cn/fmd/CN/Y2018/V12/I6/697

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