Hybrid polymer biomaterials for bone tissue regeneration

doi:10.1007/s11684-018-0664-6

Frontiers of Medicine

2019, Vol. 13

Issue (2): 189-201 https://doi.org/10.1007/s11684-018-0664-6

本期目录

Hybrid polymer biomaterials for bone tissue regeneration

Bo Lei¹, Baolin Guo¹, Kunal J. Rambhia², Peter X. Ma^1,^2,^3,^4,⁵(

)

¹. Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710054, China
². Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA
³. Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA
⁴. Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, MI 48109, USA
⁵. Department of Material Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA

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Abstract：

Native tissues possess unparalleled physiochemical and biological functions, which can be attributed to their hybrid polymer composition and intrinsic bioactivity. However, there are also various concerns or limitations over the use of natural materials derived from animals or cadavers, including the potential immunogenicity, pathogen transmission, batch to batch consistence and mismatch in properties for various applications. Therefore, there is an increasing interest in developing degradable hybrid polymer biomaterials with controlled properties for highly efficient biomedical applications. There have been efforts to mimic the extracellular protein structure such as nanofibrous and composite scaffolds, to functionalize scaffold surface for improved cellular interaction, to incorporate controlled biomolecule release capacity to impart biological signaling, and to vary physical properties of scaffolds to regulate cellular behavior. In this review, we highlight the design and synthesis of degradable hybrid polymer biomaterials and focus on recent developments in osteoconductive, elastomeric, photoluminescent and electroactive hybrid polymers. The review further exemplifies their applications for bone tissue regeneration.

Key words： hybrid polymer bone regeneration tissue engineering biomaterials

收稿日期: 2017-12-04 出版日期: 2019-03-28

Corresponding Author(s): Peter X. Ma

引用本文:

. [J]. Frontiers of Medicine, 2019, 13(2): 189-201.
Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma. Hybrid polymer biomaterials for bone tissue regeneration. Front. Med., 2019, 13(2): 189-201.

链接本文:

https://academic.hep.com.cn/fmd/CN/10.1007/s11684-018-0664-6
https://academic.hep.com.cn/fmd/CN/Y2019/V13/I2/189

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1	FMWatt, WTS Huck. Role of the extracellular matrix in regulating stem cell fate. Nat Rev Mol Cell Biol 2013; 14(8): 467–473 https://doi.org/10.1038/nrm3620 pmid: 23839578
2	IEErickson, SR Kestle, KHZellars, MJFarrell, MKim, JA Burdick, RLMauck. High mesenchymal stem cell seeding densities in hyaluronic acid hydrogels produce engineered cartilage with native tissue properties. Acta Biomater 2012; 8(8): 3027–3034 https://doi.org/10.1016/j.actbio.2012.04.033 pmid: 22546516
3	SSLee, BJ Huang, SRKaltz, SSur, CJ Newcomb, SRStock, RNShah, SIStupp. Bone regeneration with low dose BMP-2 amplified by biomimetic supramolecular nanofibers within collagen scaffolds. Biomaterials 2013; 34(2): 452–459 https://doi.org/10.1016/j.biomaterials.2012.10.005 pmid: 23099062
4	SVDorozhkin. Calcium orthophosphate-containing biocomposites and hybrid biomaterials for biomedical applications. J Funct Biomater 2015; 6(3): 708–832 https://doi.org/10.3390/jfb6030708 pmid: 26262645
5	WWu, WG Wang, JSLi. Star polymers: advances in biomedical applications. Prog Polym Sci 2015; 46: 55–85 https://doi.org/10.1016/j.progpolymsci.2015.02.002
6	JNicolas, S Mura, DBrambilla, NMackiewicz, PCouvreur. Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery. Chem Soc Rev 2013; 42(3): 1147–1235 https://doi.org/10.1039/C2CS35265F pmid: 23238558
7	HYTian, ZH Tang, XLZhuang, XSChen, XBJing. Biodegradable synthetic polymers: preparation, functionalization and biomedical application. Prog Polym Sci 2012; 37(2): 237–280 https://doi.org/10.1016/j.progpolymsci.2011.06.004
8	ZPan, J Ding. Poly(lactide-co-glycolide) porous scaffolds for tissue engineering and regenerative medicine. Interface Focus 2012; 2(3): 366–377 https://doi.org/10.1098/rsfs.2011.0123 pmid: 23741612
9	JCIgwe, PE Mikael, SPNukavarapu. Design, fabrication and in vitro evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering. J Tissue Eng Regen Med 2014; 8(2): 131–142 https://doi.org/10.1002/term.1506 pmid: 22689304
10	JVenkatesan, I Bhatnagar, PManivasagan, KHKang, SKKim. Alginate composites for bone tissue engineering: a review. Int J Biol Macromol 2015; 72: 269–281 https://doi.org/10.1016/j.ijbiomac.2014.07.008 pmid: 25020082
11	JVenkatesan, PA Vinodhini, PNSudha, SKKim. Chitin and chitosan composites for bone tissue regeneration. Adv Food Nutr Res 2014;73: 59–81 PMID: 25300543 https://doi.org/10.1016/B978-0-12-800268-1.00005-6
12	RYunus Basha, TSSampath Kumar, MDoble. Design of biocomposite materials for bone tissue regeneration. Mater Sci Eng C 2015; 57: 452–463 https://doi.org/10.1016/j.msec.2015.07.016 pmid: 26354284
13	FSun, H Zhou, JLee. Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regeneration. Acta Biomater 2011; 7(11): 3813–3828 https://doi.org/10.1016/j.actbio.2011.07.002 pmid: 21784182
14	KGkioni, SCG Leeuwenburgh, TELDouglas, AGMikos, JAJansen. Mineralization of hydrogels for bone regeneration. Tissue Eng Part B Rev 2010; 16(6): 577–585 https://doi.org/10.1089/ten.teb.2010.0462 pmid: 20735319
15	QWei, J Lu, QWang, HFan, X Zhang. Novel synthesis strategy for composite hydrogel of collagen/hydroxyapatite-microsphere originating from conversion of CaCO3 templates. Nanotechnology 2015; 26(11): 115605 https://doi.org/10.1088/0957-4484/26/11/115605 pmid: 25719911
16	TNVo, SR Shah, SLu, AMTatara, EJLee, TT Roh, YTabata, AGMikos. Injectable dual-gelling cell-laden composite hydrogels for bone tissue engineering. Biomaterials 2016; 83: 1–11 https://doi.org/10.1016/j.biomaterials.2015.12.026 pmid: 26773659
17	MRNejadnik, AG Mikos, JAJansen, SCGLeeuwenburgh. Facilitating the mineralization of oligo(poly(ethylene glycol) fumarate) hydrogel by incorporation of hydroxyapatite nanoparticles. J Biomed Mater Res A 2012; 100(5): 1316–1323 https://doi.org/10.1002/jbm.a.34071 pmid: 22374694
18	SSamavedi, AR Whittington, ASGoldstein. Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior. Acta Biomater 2013; 9(9): 8037–8045 https://doi.org/10.1016/j.actbio.2013.06.014 pmid: 23791671
19	GWei, Q Jin, WVGiannobile, PXMa. The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. Biomaterials 2007; 28(12): 2087–2096 https://doi.org/10.1016/j.biomaterials.2006.12.028 pmid: 17239946
20	RZhang, PX Ma. Poly(α-hydroxyl acids)/hydroxyapatite porous composites for bone-tissue engineering. I. Preparation and morphology. J Biomed Mater Res 1999; 44(4): 446–455 https://doi.org/10.1002/(SICI)1097-4636(19990315)44:4<446::AID-JBM11>3.0.CO;2-F pmid: 10397949
21	SKango, S Kalia, ACelli, JNjuguna, YHabibi, RKumar. Surface modification of inorganic nanoparticles for development of organic-inorganic nanocomposites—a review. Prog Polym Sci 2013; 38(8): 1232–1261 https://doi.org/10.1016/j.progpolymsci.2013.02.003
22	SPina, JM Oliveira, RLReis. Natural-based nanocomposites for bone tissue engineering and regenerative medicine: a review. Adv Mater 2015; 27(7): 1143–1169 https://doi.org/10.1002/adma.201403354 pmid: 25580589
23	NGSahoo, YZ Pan, LLi, CBHe. Nanocomposites for bone tissue regeneration. Nanomedicine (Lond) 2013; 8(4): 639–653 https://doi.org/10.2217/nnm.13.44 pmid: 23560413
24	PXMa, R Zhang, GXiao, RFranceschi. Engineering new bone tissue in vitro on highly porous poly(α-hydroxyl acids)/hydroxyapatite composite scaffolds. J Biomed Mater Res 2001; 54(2): 284–293 https://doi.org/10.1002/1097-4636(200102)54:2<284::AID-JBM16>3.0.CO;2-W pmid: 11093189
25	SShinzato, T Nakamura, KAndo, TKokubo, YKitamura. Mechanical properties and osteoconductivity of new bioactive composites consisting of partially crystallized glass beads and poly(methyl methacrylate). J Biomed Mater Res 2002; 60(4): 556–563 https://doi.org/10.1002/jbm.10098 pmid: 11948514
26	VAKoleganova, SM Bernier, SJDixon, ASRizkalla. Bioactive glass/polymer composite materials with mechanical properties matching those of cortical bone. J Biomed Mater Res A 2006; 77(3): 572–579 https://doi.org/10.1002/jbm.a.30561 pmid: 16506172
27	MMarcolongo, P Ducheyne, JGarino, ESchepers. Bioactive glass fiber/polymeric composites bond to bone tissue. J Biomed Mater Res 1998; 39(1): 161–170 https://doi.org/10.1002/(SICI)1097-4636(199801)39:1<161::AID-JBM18>3.0.CO;2-I pmid: 9429107
28	PKerativitayanan, AK Gaharwar. Elastomeric and mechanically stiff nanocomposites from poly(glycerol sebacate) and bioactive nanosilicates. Acta Biomater 2015; 26: 34–44 https://doi.org/10.1016/j.actbio.2015.08.025 pmid: 26297886
29	XZhao, Y Wu, YDu, XChen, B Lei, YXue, PXMa. A highly bioactive and biodegradable poly(glycerol sebacate)–silica glass hybrid elastomer with tailored mechanical properties for bone tissue regeneration. J Mater Chem B Mater Biol Med 2015; 3(16): 3222–3233 https://doi.org/10.1039/C4TB01693A
30	YZDu, M Yu, JGe, PXMa, XF Chen, BLei. Development of a multifunctional platform based on strong, intrinsically photoluminescent and antimicrobial silica-poly(citrates)-based hybrid biodegradable elastomers for bone regeneration. Adv Funct Mater 2015; 25(31): 5016–5029 https://doi.org/10.1002/adfm.201501712
31	YZDu, J Ge, YPShao, PXMa, XF Chen, BLei. Development of silica grafted poly(1,8-octanediol-co-citrates) hybrid elastomers with highly tunable mechanical properties and biocompatibility. J Mater Chem B Mater Biol Med 2015; 3(15): 2986–3000 https://doi.org/10.1039/C4TB02089H
32	RBalint, NJ Cassidy, SHCartmell. Conductive polymers: towards a smart biomaterial for tissue engineering. Acta Biomater 2014; 10(6): 2341–2353 https://doi.org/10.1016/j.actbio.2014.02.015 pmid: 24556448
33	ELHopley, S Salmasi, DMKalaskar, AMSeifalian. Carbon nanotubes leading the way forward in new generation 3D tissue engineering. Biotechnol Adv 2014; 32(5): 1000–1014 https://doi.org/10.1016/j.biotechadv.2014.05.003 pmid: 24858314
34	XLiu, JM Holzwarth, PXMa. Functionalized synthetic biodegradable polymer scaffolds for tissue engineering. Macromol Biosci 2012; 12(7): 911–919 https://doi.org/10.1002/mabi.201100466 pmid: 22396193
35	JRJones. Review of bioactive glass: from Hench to hybrids. Acta Biomater 2013; 9(1): 4457–4486 https://doi.org/10.1016/j.actbio.2012.08.023 pmid: 22922331
36	BLei, XF Chen, YJWang, NZhao. Synthesis and in vitro bioactivity of novel mesoporous hollow bioactive glass microspheres. Mater Lett 2009; 63(20): 1719–1721 https://doi.org/10.1016/j.matlet.2009.04.041
37	BLei, X Chen, YWang, NZhao, C Du, LFang. Surface nanoscale patterning of bioactive glass to support cellular growth and differentiation. J Biomed Mater Res A 2010; 94(4): 1091–1099 pmid: 20694976
38	XFChen, B Lei, YJWang, NZhao. Morphological control and in vitro bioactivity of nanoscale bioactive glasses. J Non-Cryst Solids 2009; 355(13): 791–796 https://doi.org/10.1016/j.jnoncrysol.2009.02.005
39	SMZakaria, SH Sharif Zein, MROthman, FYang, JA Jansen. Nanophase hydroxyapatite as a biomaterial in advanced hard tissue engineering: a review. Tissue Eng Part B Rev 2013; 19(5): 431–441 https://doi.org/10.1089/ten.teb.2012.0624 pmid: 23557483
40	ARBoccaccini, M Erol, WJStark, DMohn, ZK Hong, JFMano. Polymer/bioactive glass nanocomposites for biomedical applications: a review. Compos Sci Technol 2010; 70(13): 1764–1776 https://doi.org/10.1016/j.compscitech.2010.06.002
41	BLei, KH Shin, DYNoh, YHKoh, WY Choi, HEKim. Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly(e-caprolactone) polymer for bone tissue regeneration. J Biomed Mater Res Part B Appl Biomater 2012; 100B (4): 967–975 https://doi.org/10.1002/jbm.b.32659
42	BLei, XF Chen, XHan, JAZhou. Versatile fabrication of nanoscale sol-gel bioactive glass particles for efficient bone tissue regeneration. J Mater Chem 2012; 22(33): 16906–16913 https://doi.org/10.1039/c2jm31384g
43	BLei, KH Shin, DYNoh, IHJo, YH Koh, HEKim, SEKim. Sol-gel derived nanoscale bioactive glass (NBG) particles reinforced poly(ε-caprolactone) composites for bone tissue engineering. Mater Sci Eng C 2013; 33(3): 1102–1108 https://doi.org/10.1016/j.msec.2012.11.039 pmid: 23827548
44	SIRoohani-Esfahani, SNouri-Khorasani, ZLu, R Appleyard, HZreiqat. The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials 2010; 31(21): 5498–5509 https://doi.org/10.1016/j.biomaterials.2010.03.058 pmid: 20398935
45	MNRahaman, DE Day, BSBal, QFu, SB Jung, LFBonewald, APTomsia. Bioactive glass in tissue engineering. Acta Biomater 2011; 7(6): 2355–2373 https://doi.org/10.1016/j.actbio.2011.03.016 pmid: 21421084
46	MPeter, NS Binulal, SVNair, NSelvamurugan, HTamura, RJayakumar. Novel biodegradable chitosan-gelatin/nano-bioactive glass ceramic composite scaffolds for alveolar bone tissue engineering. Chem Eng J 2010; 158(2): 353–361 https://doi.org/10.1016/j.cej.2010.02.003
47	MMozafari, F Moztarzadeh, MRabiee, MAzami, SMaleknia, MTahriri, ZMoztarzadeh, NNezafati. Development of macroporous nanocomposite scaffolds of gelatin/bioactive glass prepared through layer solvent casting combined with lamination technique for bone tissue engineering. Ceram Int 2010; 36(8): 2431–2439 https://doi.org/10.1016/j.ceramint.2010.07.010
48	ZHong, RL Reis, JFMano. Preparation and in vitro characterization of scaffolds of poly(L-lactic acid) containing bioactive glass ceramic nanoparticles. Acta Biomater 2008; 4(5): 1297–1306 https://doi.org/10.1016/j.actbio.2008.03.007 pmid: 18439885
49	XLiu, LA Smith, JHu, PXMa. Biomimetic nanofibrous gelatin/apatite composite scaffolds for bone tissue engineering. Biomaterials 2009; 30(12): 2252–2258 https://doi.org/10.1016/j.biomaterials.2008.12.068 pmid: 19152974
50	CHe, G Xiao, XJin, CSun, PX Ma. Electrodeposition on nanofibrous polymer scaffolds: rapid mineralization, tunable calcium phosphate composition and topography. Adv Funct Mater 2010; 20(20): 3568–3576 https://doi.org/10.1002/adfm.201000993 pmid: 21673827
51	BLei, L Wang, XFChen, SKChae. Biomimetic and molecular level-based silicate bioactive glass-gelatin hybrid implants for loading-bearing bone fixation and repair. J Mater Chem B Mater Biol Med 2013; 1(38): 5153–5162 https://doi.org/10.1039/c3tb20941e
52	JChen, W Que, YXing, BLei. Molecular level-based bioactive glass-poly (caprolactone) hybrids monoliths with porous structure for bone tissue repair. Ceram Int 2015; 41(2): 3330–3334 https://doi.org/10.1016/j.ceramint.2014.10.147
53	MXie, J Ge, BLei, QZhang, XChen, PX Ma. Star-shaped, biodegradable, and elastomeric PLLA-PEG-POSS hybrid membrane with biomineralization activity for guiding bone tissue regeneration. Macromol Biosci 2015; 15(12): 1656–1662 https://doi.org/10.1002/mabi.201500237 pmid: 26241149
54	JChen, Y Du, WQue, YXing, X Chen, BLei. Crack-free polydimethylsiloxane-bioactive glass-poly(ethylene glycol) hybrid monoliths with controlled biomineralization activity and mechanical property for bone tissue regeneration. Colloids Surf B Biointerfaces 2015; 136: 126–133 https://doi.org/10.1016/j.colsurfb.2015.08.053 pmid: 26381696
55	JChen, YZ Du, WXQue, YLXing, BLei. Content-dependent biomineralization activity and mechanical properties based on polydimethylsiloxane-bioactive glass-poly(caprolactone) hybrids monoliths for bone tissue regeneration. Rsc Adv. 2015; 5(75): 61309–61317 https://doi.org/10.1039/C5RA09075J
56	BLei, KH Shin, YWMoon, DYNoh, YH Koh, YJin, HEKim. Synthesis and bioactivity of sol-gel derived porous, bioactive glass microspheres using chitosan as novel biomolecular template. J Am Ceram Soc 2012; 95(1): 30–33 https://doi.org/10.1111/j.1551-2916.2011.04918.x
57	OMahony, O Tsigkou, CIonescu, CMinelli, LLing, R Hanly, MESmith, MMStevens, JRJones. Silica-gelatin hybrids with tailorable degradation and mechanical properties for tissue regeneration. Adv Funct Mater 2010; 20(22): 3835–3845 https://doi.org/10.1002/adfm.201000838
58	BLei, KH Shin, IHJo, YHKoh, HE Kim. Highly porous gelatin-silica hybrid scaffolds with textured surfaces using new direct foaming/freezing technique. Mater Chem Phys 2014; 145(3): 397–402 https://doi.org/10.1016/j.matchemphys.2013.09.057
59	BLei, KH Shin, DYNoh, IHJo, YH Koh, WYChoi, HEKim. Nanofibrous gelatin-silica hybrid scaffolds mimicking the native extracellular matrix (ECM) using thermally induced phase separation. J Mater Chem 2012; 22(28): 14133–14140 https://doi.org/10.1039/c2jm31290e
60	YMXue, L Wang, YPShao, JYan, XF Chen, BLei. Facile and green fabrication of biomimetic gelatin-siloxane hybrid hydrogel with highly elastic properties for biomedical applications. Chem Eng J 2014; 251: 158–164 https://doi.org/10.1016/j.cej.2014.04.049
61	SDuan, X Yang, FMei, YTang, X Li, YShi, JMao, H Zhang, QCai. Enhanced osteogenic differentiation of mesenchymal stem cells on poly(L-lactide) nanofibrous scaffolds containing carbon nanomaterials. J Biomed Mater Res A 2015; 103(4): 1424–1435 https://doi.org/10.1002/jbm.a.35283 pmid: 25046153
62	BSitharaman, X Shi, XFWalboomers, HLiao, V Cuijpers, LJWilson, AGMikos, JAJansen. In vivo biocompatibility of ultra-short single-walled carbon nanotube/biodegradable polymer nanocomposites for bone tissue engineering. Bone 2008; 43(2): 362–370 https://doi.org/10.1016/j.bone.2008.04.013 pmid: 18541467
63	SPark, J Park, IJo, SPCho, D Sung, SRyu, MPark, KA Min, JKim, SHong, BH Hong, BSKim. In situ hybridization of carbon nanotubes with bacterial cellulose for three-dimensional hybrid bioscaffolds. Biomaterials 2015; 58: 93–102 https://doi.org/10.1016/j.biomaterials.2015.04.027 pmid: 25941786
64	IAWBSiqueira, MAF Corat, BCavalcanti, WARibeiro Neto, AAMartin, REBretas, FRMarciano, AOLobo. In vitro and in vivo studies of novel poly(D,L-lactic acid), superhydrophilic carbon nanotubes, and nanohydroxyapatite scaffolds for bone regeneration. ACS Appl Mater Interfaces 2015; 7(18): 9385–9398 https://doi.org/10.1021/acsami.5b01066 pmid: 25899398
65	PEMikael, AR Amini, JBasu, MJosefina Arellano-Jimenez, CTLaurencin, MMSanders, CBarry Carter, SPNukavarapu. Functionalized carbon nanotube reinforced scaffolds for bone regenerative engineering: fabrication, in vitro and in vivo evaluation. Biomed Mater 2014; 9(3): 035001 https://doi.org/10.1088/1748-6041/9/3/035001 pmid: 24687391
66	EHirata, C Ménard-Moyon, EVenturelli, HTakita, FWatari, ABianco, AYokoyama. Carbon nanotubes functionalized with fibroblast growth factor accelerate proliferation of bone marrow-derived stromal cells and bone formation. Nanotechnology 2013; 24(43): 435101 https://doi.org/10.1088/0957-4484/24/43/435101 pmid: 24077482
67	BDas, P Chattopadhyay, SMaji, AUpadhyay, MDas Purkayastha, CLMohanta, TKMaity, NKarak. Bio-functionalized MWCNT/hyperbranched polyurethane bionanocomposite for bone regeneration. Biomed Mater 2015; 10(2): 025011 https://doi.org/10.1088/1748-6041/10/2/025011 pmid: 25886640
68	BLei, KH Shin, YHKoh, HEKim. Porous gelatin-siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration. J Biomed Mater Res B Appl Biomater 2014; 102(7): 1528–1536 https://doi.org/10.1002/jbm.b.33133 pmid: 24596176
69	DLNettles, A Chilkoti, LASetton. Applications of elastin-like polypeptides in tissue engineering. Adv Drug Deliv Rev 2010; 62(15): 1479–1485 https://doi.org/10.1016/j.addr.2010.04.002 pmid: 20385185
70	QZChen, SL Liang, GAThouas. Elastomeric biomaterials for tissue engineering. Prog Polym Sci 2013; 38(3-4): 584–671 https://doi.org/10.1016/j.progpolymsci.2012.05.003
71	SSant, CM Hwang, SHLee, AKhademhosseini. Hybrid PGS-PCL microfibrous scaffolds with improved mechanical and biological properties. J Tissue Eng Regen Med 2011; 5(4): 283–291 https://doi.org/10.1002/term.313 pmid: 20669260
72	MKharaziha, M Nikkhah, SRShin, NAnnabi, NMasoumi, AKGaharwar, GCamci-Unal, AKhademhosseini. PGS:Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues. Biomaterials 2013; 34(27): 6355–6366 https://doi.org/10.1016/j.biomaterials.2013.04.045 pmid: 23747008
73	LBokobza. Mechanical, electrical and spectroscopic investigations of carbon nanotube-reinforced elastomers. Vib Spectrosc 2009; 51(1): 52–59 https://doi.org/10.1016/j.vibspec.2008.10.001
74	AHPei, JM Malho, JRuokolainen, QZhou, LA Berglund. Strong nanocomposite reinforcement effects in polyurethane elastomer with low volume fraction of cellulose nanocrystals. Macromolecules 2011; 44(11): 4422–4427 https://doi.org/10.1021/ma200318k
75	DRPaul, JE Mark. Fillers for polysiloxane (“silicone”) elastomers. Prog Polym Sci 2010; 35(7): 893–901 https://doi.org/10.1016/j.progpolymsci.2010.03.004
76	AMoradi, A Dalilottojari, BPingguan-Murphy, IDjordjevic. Fabrication and characterization of elastomeric scaffolds comprised of a citric acid-based polyester/hydroxyapatite microcomposite. Mater Des 2013; 50: 446–450 https://doi.org/10.1016/j.matdes.2013.03.026
77	SLLiang, WD Cook, GAThouas, QZChen. The mechanical characteristics and in vitro biocompatibility of poly(glycerol sebacate)-bioglass elastomeric composites. Biomaterials 2010; 31(33): 8516–8529 https://doi.org/10.1016/j.biomaterials.2010.07.105 pmid: 20739061
78	YDu, M Yu, XChen, PXMa, B Lei. Development of biodegradable poly(citrate)-polyhedral oligomeric silsesquioxanes hybrid elastomers with high mechanical properties and osteogenic differentiation activity. ACS Appl Mater Interfaces 2016; 8(5): 3079–3091 https://doi.org/10.1021/acsami.5b10378 pmid: 26765285
79	YDu, Y Xue, PXMa, XChen, B Lei. Biodegradable, elastomeric, and intrinsically photoluminescent poly(silicon-citrates) with high photostability and biocompatibility for tissue regeneration and bioimaging. Adv Healthc Mater 2016; 5(3): 382–392 https://doi.org/10.1002/adhm.201500643 pmid: 26687865
80	NKGuimard, N Gomez, CESchmidt. Conducting polymers in biomedical engineering. Prog Polym Sci 2007; 32(8-9): 876–921 https://doi.org/10.1016/j.progpolymsci.2007.05.012
81	AOPatil, AJ Heeger, FWudl. Optical-properties of conducting polymers. Chem Rev 1988; 88(1): 183–200 https://doi.org/10.1021/cr00083a009
82	BLGuo, L Glavas, ACAlbertsson. Biodegradable and electrically conducting polymers for biomedical applications. Prog Polym Sci 2013; 38(9): 1263–1286 https://doi.org/10.1016/j.progpolymsci.2013.06.003
83	MXie, L Wang, JGe, BGuo, PX Ma. Strong electroactive biodegradable shape memory polymer networks based on star-shaped polylactide and aniline trimer for bone tissue engineering. ACS Appl Mater Interfaces 2015; 7(12): 6772–6781 https://doi.org/10.1021/acsami.5b00191 pmid: 25742188
84	MXie, L Wang, BGuo, ZWang, YE Chen, PXMa. Ductile electroactive biodegradable hyperbranched polylactide copolymers enhancing myoblast differentiation. Biomaterials 2015; 71: 158–167 https://doi.org/10.1016/j.biomaterials.2015.08.042 pmid: 26335860
85	JGHardy, SA Geissler, DAguilar Jr, MKVillancio-Wolter, DJMouser, RCSukhavasi, RCCornelison, LWTien, RCPreda, RSHayden, JKChow, LNguy, DL Kaplan, CESchmidt. Instructive conductive 3D silk foam-based bone tissue scaffolds enable electrical stimulation of stem cells for enhanced osteogenic differentiation. Macromol Biosci 2015; 15(11): 1490–1496 https://doi.org/10.1002/mabi.201500171 pmid: 26033953
86	SMeng, Z Zhang, MRouabhia. Accelerated osteoblast mineralization on a conductive substrate by multiple electrical stimulation. J Bone Miner Metab 2011; 29(5): 535–544 https://doi.org/10.1007/s00774-010-0257-1 pmid: 21327884
87	SMeng, M Rouabhia, ZZhang. Electrical stimulation modulates osteoblast proliferation and bone protein production through heparin-bioactivated conductive scaffolds. Bioelectromagnetics 2013; 34(3): 189–199 https://doi.org/10.1002/bem.21766 pmid: 23124591
88	MYazdimamaghani, M Razavi, MMozafari, DVashaee, HKotturi, LTayebi. Biomineralization and biocompatibility studies of bone conductive scaffolds containing poly(3,4-ethylenedioxythiophene): poly(4-styrene sulfonate) (PEDOT:PSS). J Mater Sci Mater Med 2015; 26(12):274 https://doi.org/10.1007/s10856-015-5599-8 pmid: 26543020
89	JPelto, M Björninen, APälli, ETalvitie, JHyttinen, BMannerström, RSuuronen Seppanen, MKellomäki, SMiettinen, SHaimi. Novel polypyrrole-coated polylactide scaffolds enhance adipose stem cell proliferation and early osteogenic differentiation. Tissue Eng Part A 2013; 19(7-8): 882–892 https://doi.org/10.1089/ten.tea.2012.0111 pmid: 23126228
90	BGuo, B Lei, PLi, PXMa. Functionalized scaffolds to enhance tissue regeneration. Regen Biomater 2015; 2(1): 47–57 https://doi.org/10.1093/rb/rbu016 pmid: 25844177
91	TJiang, EJ Carbone, KWHLo, CTLaurencin. Electrospinning of polymer nanofibers for tissue regeneration. Prog Polym Sci 2015; 46: 1–24 https://doi.org/10.1016/j.progpolymsci.2014.12.001
92	ODSchneider, F Weber, TJBrunner, SLoher, MEhrbar, PRSchmidlin, WJStark. In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects. Acta Biomater 2009; 5(5): 1775–1784 https://doi.org/10.1016/j.actbio.2008.11.030 pmid: 19121610
93	EJLee, DS Shin, HEKim, HWKim, YH Koh, JHJang. Membrane of hybrid chitosan-silica xerogel for guided bone regeneration. Biomaterials 2009; 30(5): 743–750 https://doi.org/10.1016/j.biomaterials.2008.10.025 pmid: 19027950
94	MXie, J Ge, YXue, YDu, B Lei, PXMa. Photo-crosslinked fabrication of novel biocompatible and elastomeric star-shaped inositol-based polymer with highly tunable mechanical behavior and degradation. J Mech Behav Biomed Mater 2015; 51: 163–168 https://doi.org/10.1016/j.jmbbm.2015.07.011 pmid: 26253207
95	LCLi, M Yu, PXMa, BLGuo. Electroactive degradable copolymers enhancing osteogenic differentiation from bone marrow derived mesenchymal stem cells. J Mater Chem B Mater Biol Med 2016; 4(3): 471–481 https://doi.org/10.1039/C5TB01899D

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