Please wait a minute...
Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

邮发代号 80-967

2019 Impact Factor: 3.421

Frontiers of Medicine  2020, Vol. 14 Issue (2): 225-228   https://doi.org/10.1007/s11684-020-0753-1
  本期目录
2019 novel coronavirus outbreak: a quiz or final exam?
Jiuyang Xu1, Yijun Chen1, Hao Chen1, Bin Cao2,3,4()
1. Tsinghua University School of Medicine, Beijing 100084, China
2. Department of Pulmonary and Critical Care Medicine, Center for Respiratory Medicine, China-Japan Friendship Hospital, Beijing 100029, China
3. Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China
4. Tsinghua University-Peking University Joint Center for Life Sciences, Beijing 100084, China
 全文: PDF(440 KB)   HTML
Abstract

The 2019 novel coronavirus (2019-nCoV) is an emerging pathogen and is threatening the global health. Strikingly, more than 28 000 cases and 550 deaths have been reported within two months from disease emergence. Armed with experience from previous epidemics in the last two decades, clinicians, scientists, officials, and citizens in China are all contributing to the prevention of further 2019-nCoV transmission. Efficient preliminary work has enabled us to understand the basic characteristics of 2019-nCoV, but there are still many unanswered questions. It is too early now to judge our performance in this outbreak. Continuous and strengthened efforts should be made not only during the epidemic, but also afterwards in order to prepare for any incoming challenges.

Key words2019-nCoV    novel coronavirus    epidemic    public response
收稿日期: 2020-02-05      出版日期: 2020-05-09
Corresponding Author(s): Bin Cao   
 引用本文:   
. [J]. Frontiers of Medicine, 2020, 14(2): 225-228.
Jiuyang Xu, Yijun Chen, Hao Chen, Bin Cao. 2019 novel coronavirus outbreak: a quiz or final exam?. Front. Med., 2020, 14(2): 225-228.
 链接本文:  
https://academic.hep.com.cn/fmd/CN/10.1007/s11684-020-0753-1
https://academic.hep.com.cn/fmd/CN/Y2020/V14/I2/225
Fig.1  
1 National Health Commission of China. The latest information for 2019 novel coronavirus infected pneumonia by Feb 5, 2020. 2020. (in Chinese) (accessed February 6, 2020)
2 World Health Organization. Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 2020. (accessed February 4, 2020)
3 JF Chan, S Yuan, KH Kok, KK To, H Chu, J Yang, F Xing, J Liu, CC Yip, RW Poon, HW Tsoi, SK Lo, KH Chan, VK Poon, WM Chan, JD Ip, JP Cai, VC Cheng, H Chen, CK Hui, KY Yuen. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020 Jan 24. [Epub ahead of print] doi:10.1016/S0140-6736(20)30154-9
https://doi.org/10.1016/S0140-6736(20)30154-9
4 World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. (accessed February 4, 2020)
5 World Health Organization. Pandemic (H1N1) 2009—update 112. (accessed February 4, 2020)
6 World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV) – Republic of Korea. (accessed February 4, 2020)
7 World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV). (accessed February 4, 2020)
8 MA Marra, SJ Jones, CR Astell, RA Holt, A Brooks-Wilson, YS Butterfield, J Khattra, JK Asano, SA Barber, SY Chan , A Cloutier, SM Coughlin, D Freeman, N Girn, OL Griffith, SR Leach, M Mayo, H McDonald, SB Montgomery, PK Pandoh, AS Petrescu, AG Robertson, JE Schein, A Siddiqui, DE Smailus, JM Stott, GS Yang, F Plummer, A Andonov, H Artsob, N Bastien, K Bernard, TF Booth, D Bowness, M Czub, M Drebot, L Fernando, R Flick, M Garbutt, M Gray, A Grolla, S Jones, H Feldmann, A Meyers, A Kabani, Y Li, S Normand, U Stroher, GA Tipples, S Tyler, R Vogrig, D Ward, B Watson, RC Brunham, M Krajden, M Petric, DM Skowronski, C Upton, RL Roper. The genome sequence of the SARS-associated coronavirus. Science 2003; 300(5624): 1399–1404
https://doi.org/10.1126/science.1085953 pmid: 12730501
9 A Zumla, JF Chan, EI Azhar, DS Hui, KY Yuen. Coronaviruses—drug discovery and therapeutic options. Nat Rev Drug Discov 2016; 15(5): 327–347
https://doi.org/10.1038/nrd.2015.37 pmid: 26868298
10 J Xu, W Jia, P Wang, S Zhang, X Shi, X Wang, L Zhang. Antibodies and vaccines against Middle East respiratory syndrome coronavirus.Emerg Microbes Infect 2019; 8(1): 841–856
https://doi.org/10.1080/22221751.2019.1624482
11 Ministry of Finance of the People’s Republic of China. The government at all levels continued to increase input and allocated a total of 47 billion yuan for epidemic prevention and control. (in Chinese) (accessed February 4, 2020)
12 N Zhu, D Zhang, W Wang, X Li, B Yang, J Song, X Zhao, B Huang, W Shi, R Lu, P Niu, F Zhan, X Ma, D Wang, W Xu, G Wu, GF Gao, W Tan; China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019.N Engl J Med 2020 Jan 24. [Epub ahead of print] doi: 10.1056/NEJMoa2001017
https://doi.org/10.1056/NEJMoa2001017
13 JF Chan, KH Kok, Z Zhu, H Chu, KK To, S Yuan, KY Yuen. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect 2020; 9(1): 221–236
https://doi.org/10.1080/22221751.2020.1719902
14 L Ren, Y Wang, Z Wu, Z Xiang, L Guo, T, Xu Y Jiang, Y Xiong, Y Li, H Li, G Fan, X Gu, Y Xiao, H Gao, J Xu, F Yang, X Wang, C Wu, L Chen, Y Liu, B Liu, J Yang, X Wang, J Dong, L Li, C Huang, J Zhao, Y Hu, Z Cheng, L Liu, Z Qian, C Qin, Q Jin, B Cao, J Wang. Identification of a novel bat-origin coronavirus causing severe pneumonia in human: a descriptive study. Chin Med J 2020. [Epub ahead of print] doi: 10.3760/cma.j.issn.0366-6999.2020.00.E001
https://doi.org/10.3760/cma.j.issn.0366-6999.2020.00.E001
15 R Lu, X Zhao, J Li, P Niu, B Yang, H Wu, W Wang, H Song, B Huang, N Zhu, Y Bi, X Ma, F Zhan, L Wang, T Hu, H Zhou, Z Hu, W Zhou, L Zhao, J Chen, Y Meng, J Wang, Y Lin, J Yuan, Z Xie, J Ma, W J Liu, D Wang, W Xu, EC Holmes, GF Gao, G Wu, W Chen, W Shi, W Tan. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020 Jan 30. [Epub ahead of print] doi: 10.1016/S0140-6736(20)30251-8
https://doi.org/10.1016/S0140-6736(20)30251-8
16 P Zhou, XL Yang, XG Wang, B Hu, L Zhang, W Zhang, HR Si, Y Zhu, B Li, CL Huang, HD Chen, J Chen, Y Luo, H Guo, RD Jiang, MQ Liu, Y Chen, XR Shen, X Wang, XS Zheng, K Zhao, QJ Chen, F Deng, LL Liu, B Yan, FX Zhan, YY Wang, GF Xiao, ZL Shi. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020 Feb 3. [Epub ahead of print] doi: 10.1038/s41586-020-2012-7
https://doi.org/10.1038/s41586-020-2012-7
17 Q Li, X Guan, P Wu, X Wang, L Zhou, Y Tong, R Ren, KSM Leung, EHY Lau, JY Wong, X Xing, N Xiang, Y Wu, C Li, Q Chen, D Li, T Liu, J Zhao, M Li, W Tu, C Chen, L Jin, R Yang, Q Wang, S Zhou, R Wang, H Liu, Y Luo, Y Liu, G Shao, H Li, Z Tao, Y Yang, Z Deng, B Liu, Z Ma, Y Zhang, G Shi, TTY Lam, JTK Wu, GF Gao, BJ Cowling, B Yang, GM Leung, Z Feng. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 2020 Jan 29. [Epub ahead of print] doi: 10.1056/NEJMoa2001316
https://doi.org/10.1056/NEJMoa2001316
18 C Huang, Y Wang, X Li, L Ren, J Zhao, Y Hu, L Zhang, G Fan, J Xu, X Gu, Z Cheng, T Yu, J Xia, Y Wei, W Wu, X Xie, W Yin, H Li, M Liu, Y Xiao, H Gao, L Guo, J Xie, G Wang, R Jiang, Z Gao, Q Jin, J Wang, B Cao. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020 Jan 24. [Epub ahead of print] doi: 10.1016/S0140-6736(20)30183-5
https://doi.org/10.1016/S0140-6736(20)30183-5
19 N Chen, M Zhou, X Dong, J Qu, F Gong, Y Han, Y Qiu, J Wang, Y Liu, Y Wei, J Xia, T Yu, X Zhang, L Zhang. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020 Jan 30. [Epub ahead of print] doi: 10.1016/S0140-6736(20)30211-7
https://doi.org/10.1016/S0140-6736(20)30211-7
20 National Health Commission of China. The issuance of the diagnosis and treatment programme for pneumonia of novel coronavirus infections (pilot fifth edition). 2020. (in Chinese) (accessed February 5, 2020)
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed