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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

邮发代号 80-967

2019 Impact Factor: 3.421

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Frontiers of Medicine  2020, Vol. 14 Issue (2): 193-198   https://doi.org/10.1007/s11684-020-0772-y
  本期目录
Clinical characteristics of 19 neonates born to mothers with COVID-19
Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong()
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
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Abstract：

The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19. Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29, 2020. Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19. We prospectively collected and analyzed data of mothers and infants. There are 19 neonates included in the research. Among them, 10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab, and 9 mothers were clinically diagnosed with COVID-19. Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days. No fetal distress was found. Gestational age of the neonates was 38.6±1.5 weeks, and average birth weight was 3293±425 g. SARS-CoV-2 RT-PCR in throat swab, urine, and feces of all neonates were negative. SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too. None of the neonates developed clinical, radiologic, hematologic, or biochemical evidence of COVID-19. No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study. The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers.
Key words： coronavirus disease 2019    severe acute respiratory syndrome-associated coronavirus    maternal-infant infection    newborn
收稿日期: 2020-03-15      出版日期: 2020-05-09
Corresponding Author(s): Zhihui Rong   
 引用本文:   
. [J]. Frontiers of Medicine, 2020, 14(2): 193-198.
Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong. Clinical characteristics of 19 neonates born to mothers with COVID-19. Front. Med., 2020, 14(2): 193-198.
 链接本文:  
https://academic.hep.com.cn/fmd/CN/10.1007/s11684-020-0772-y
https://academic.hep.com.cn/fmd/CN/Y2020/V14/I2/193
Fig.1  
Case ?No. Throat swab for ?SARS-CoV-2 Age? (year) Gestational ?age (week) Fever Cough Diarrhea Time between ?symptoms ?and delivery Antiviral treat-?ment before ?delivery
1 + 36 36+3 Yes No No 21 days No
2 + 26 35+2 Yes Yes No 9 days Yes
3 + 38 38+2 Yes Yes No 7 days Yes
4 + 34 40 Yes No No 8 hours No
5 + 31 41+2 Yes No No 12 days Yes
6 + 34 38+4 Yes No No 7 days No
7 + 30 39+5 No Yes No 10 days Yes
8 + 33 38+2 No No Yes 32 hours No
9 + 34 38+2 Yes No No 4 days No
10 + 33 37+2 No Yes No 21 days Yes
11 – 27 39+5 Yes No No 4 days Yes
12 – 30 39+1 No No No – No
13 – 26 37+5 No No Yes 2 days No
14 – 30 38+6 Yes No No 1 day No
15 – 27 41+2 No No No – No
16 – 26 39 No No No – No
17 – 30 38 Yes No No 1 day No
18 – 33 39 Yes Yes No 2 days No
19 – 33 38 No No No – No
Tab.1  
Case ?No. Birth ?weight (g) White blood cell ?(×109 cells/L) Lymphocytes ?(×109 cells/L) Neutrophil ?(×109 cells/L) Platelets ?(×109 cells/L) C-reactive protein ?(g/L) Alanine ?transaminase ?(IU/L) Aspartate ?transaminase ?(IU/L) Urea ?(mmol/L) Creatinine ?(μmol/L)
1 2840 11.9 2.41 6.91 301 2.2 7 31 3.7 65
2 2500 15.46 4.29 8.23 154 4.2 10 40 2.3 68
3 2920 16.53 3.68 11.41 260 2.2 29 87 2.5 72
4 3250 12.1 7.4 4.2 224 0.1 14 52 1.93 58
5 3470 9.99 2.22 5.99 114 0.2 27 64 1.6 69
6 3250 22.19 3.31 16.4 137 0.1 18 28 1.6 66
7 3670 18 3.8 11.7 208 1.2 24 150 2.1 66
8 3180 10.66 4.01 4.91 342 0.1 6 29 1.64 47
9 3200 13.3 6.34 5.8 289 0.2 10 35 2.5 60
10 3300 16.19 6.34 8.23 312 0.3 15 26 1.5 55
11 3190 8.91 1.9 5.49 299 2.2 8 61 4 84
12 3290 12.44 3.33 7.93 295 1.4 54 340 3.7 56
13 2640 20.66 3.03 14.91 266 0.1 5 25 3.4 82
14 3710 16.88 2.22 13.51 362 9.2 9 54 3.7 62
15 4120 16.14 4.34 10.84 242 2.8 7 35 2.1 87
16 3160 20.9 2.67 16.21 300 10.8 11 70 4.3 78
17 3860 16.48 3.43 11.15 369 0.5 6 26 4.2 67
18 3930 30.43 5.43 21.52 307 1.1 15 89 5.2 95
19 3090 18.37 4.75 11.93 295 3.7 7 38 2.2 82
Median (P25–P75) 16.19 (12.1–18.37) 3.8 (3.03–4.75) 10.84 (5.99–13.51) 295 (224–312) 1.2 (0.2–3.7) 10 (7–18) 40 (29–70) 2.5 (1.93–3.7) 67 (60–78)
Mean±SD 3293±425 　 　 　 　 　 　 　 　 　
Tab.2  
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