J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China
Panpan He1, Huan Li1, Mengyi Liu1, Zhuxian Zhang1, Yuanyuan Zhang1, Chun Zhou1, Ziliang Ye1, Qimeng Wu1, Min Liang1, Jianping Jiang1, Guobao Wang1, Jing Nie1, Fan Fan Hou1, Chengzhang Liu2,3, Xianhui Qin1()
1. Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China 2. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei 230032, China 3. Institute of Biomedicine, Anhui Medical University, Hefei 230032, China
We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults. A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included. Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory. Participants with systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension. During a median follow-up duration of 6.1 years, 4269 participants developed new-onset hypertension. Overall, the association between dietary zinc intake and new-onset hypertension followed a J-shape (P for non-linearity < 0.001). The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake (per mg/day: hazard ratio (HR) 0.93; 95% confidence interval (CI) 0.88–0.98) in participants with zinc intake <10.9 mg/day, and increased with the increment of zinc intake (per mg/day: HR 1.14; 95% CI 1.11–1.16) in participants with zinc intake ≥ 10.9 mg/day. In conclusion, there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults, with an inflection point at about 10.9 mg/day.
. [J]. Frontiers of Medicine, 2023, 17(1): 156-164.
Panpan He, Huan Li, Mengyi Liu, Zhuxian Zhang, Yuanyuan Zhang, Chun Zhou, Ziliang Ye, Qimeng Wu, Min Liang, Jianping Jiang, Guobao Wang, Jing Nie, Fan Fan Hou, Chengzhang Liu, Xianhui Qin. J-shaped association between dietary zinc intake and new-onset hypertension: a nationwide cohort study in China. Front. Med., 2023, 17(1): 156-164.
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