2023,17 (6)
It is of the utmost importance to review the pandemic prevention and control and scientific research work in the past years and solve some of the remaining challenges. Scientific assessments should be made from the aspects of pattern recognition, innovation, and implementation, so as to provide reference for the prevention and control of infectious diseases in the future. We believe that the trajectory of COVID-19 response will certainly contribute to evidence-based policy-making and to building a global community of health for all. (Courtesy of Dr. Guangbiao Zhou. See pages 1011-1169 for more information.)
It is of the utmost importance to review the pandemic prevention and control and scientific research work in the past years and solve some of the remaining challenges. Scientific assessments should be made from the aspects of pattern recognition, innovation, and implementation, so as to provide reference for the prevention and control of infectious diseases in the future. We believe that the trajectory of COVID-19 response will certainly contribute to evidence-based policy-making and to building a global community of health for all. (Courtesy of Dr. Guangbiao Zhou. See pages 1011-1169 for more information.)
2023,17 (5)
The image illustrates that the anti-migraine mechanism of acupuncture involves regulating a complex metabolites/proteins network and specific brain regions. (Courtesy of Dr. Guihua Tian. See pages 993-1005 by Chong Li et al. for more information.)
2023,17 (4)
Cover Figure
The 15 quality control indicators of Chinese ICU constituting the 6 core elements and their weights based on EFA. (Courtesy of Drs. Guangliang Shan, Dawei Liu, and Xiang Zhou. See pages 675-684 by Longxiang Su et al. for more information.)
2023,17 (3)
Although the Human Genome Project has been completed for over 20 years, our understanding of the function and regulation of human genome is still far from complete. In this issue of Frontiers of Medicine, Dan Liu et al. identified a novel human protein-coding gene, LY6A. This gene encodes the candidate ortholog of the mouse stem cell marker Ly-6A/Sca-1, and it is aberrantly expressed in human pituitary tumors. In this cover image, the newly identified human LY6A protein (green) is shown being tethered to the cell membrane by a GPI anchor, and its known homolog proteins, LY6E (light blue) and LY6L (light pink), are illustrated by the side of LY6A. The 3D structures of these proteins are predicted by AlphaFold (Google DeepMind. Jumper J, et al. Highly accurate protein structure prediction with AlphaFold. Nature, 2021. Varadi M, et al. AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Research, 2021). The little yellow sticks within the structures denote the conserved disulfide bonds. (Courtesy of Drs. Chunhui Xu, Xiaojian Sun, and Zhe Bao Wu. See pages 458-475 by Dan Liu et al. for more information.)
2023,17 (2)
The image illustrates that targeting three of the most important regulatory metabolic pathways in ferroptosis can be utilized for the management of human disease. The cover art features an allusion to the Chinese drama “Romance of Three Kingdoms”, in which in the chapter “Three heroes combating Lu Bu”, the three heroes Guan Yu (representing iron (Fe) metabolism), Zhang Fei (representing lipid peroxidation (PLOO•)) and Liu Bei (representing glutathione (GSH) pathways) work together to conquer Lu Bu (representing FERROPTOSIS) in the Eastern Han Dynasty. (Courtesy of Dr. Fudi Wang. See pages 173-206 by Xue Wang et al. for more information.)
2023,17 (1)
The increased proportion of younger cervical cancer patients and earlier disease stages have increased the emphasis on preserving genital and endocrine functions and survival benefits after treatments. We conducted a prospective, randomized, multicenter clinical trial to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage cervical cancer patients after surgery. The results showed that adjuvant chemotherapy treatment was non-inferior efficacy than adjuvant CCRT in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. (Courtesy of Dr. Ding Ma. See pages 93-104 by Danhui Weng et al. for more information.)
2022,16 (6)
Blood smears and Wright–Giemsa staining was performed to observe the morphology of red blood cells in PWS patients. The malformation ratio of red blood cells increased in PWS patients. (Courtesy of Drs. Shuping Zhang and Jiajun Zhao. See pages 946-956 by Yashuang Yang et al. for more information.)
Blood smears and Wright–Giemsa staining was performed to observe the morphology of red blood cells in PWS patients. The malformation ratio of red blood cells increased in PWS patients. (Courtesy of Drs. Shuping Zhang and Jiajun Zhao. See pages 946-956 by Yashuang Yang et al. for more information.)
2022,16 (5)
Inhibition of GNAQ/11 palmitoylation inhibits GNAQ/11 oncogenic transformation by interfering with the MAPK pathway and BCL2 survival pathway in GNAQ/11-mutant uveal melanoma cells and exhibits a synergistic effect with the BCL2 inhibitor in the treatment of GNAQ/11-mutant uveal melanoma. (Courtesy of Drs. Bo Jiao and Ruibao Ren. See pages 784-798 by Yan Zhang et al. for more information.)
Inhibition of GNAQ/11 palmitoylation inhibits GNAQ/11 oncogenic transformation by interfering with the MAPK pathway and BCL2 survival pathway in GNAQ/11-mutant uveal melanoma cells and exhibits a synergistic effect with the BCL2 inhibitor in the treatment of GNAQ/11-mutant uveal melanoma. (Courtesy of Drs. Bo Jiao and Ruibao Ren. See pages 784-798 by Yan Zhang et al. for more information.)
2022,16 (4)
Cover Figure
Throat discomfort may be the principal manifestation of acute coronary syndrome, including acute myocardial infarction. Awareness of this condition will result in prompt diagnosis and reduce morbidity and mortality. (Courtesy of Dr. Yilai Shu. See pages 651-658 by Yanqing Fang et al. for more information.)
Cover Figure
Throat discomfort may be the principal manifestation of acute coronary syndrome, including acute myocardial infarction. Awareness of this condition will result in prompt diagnosis and reduce morbidity and mortality. (Courtesy of Dr. Yilai Shu. See pages 651-658 by Yanqing Fang et al. for more information.)
2022,16 (3)
Abivertinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, could inhibit MK differentiation and platelet biogenesis and might be an agent for thrombocythemia. (Courtesy of Dr. Jie Jin. See pages 416-428 by Jiansong Huang et al. for more information.)
Abivertinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor, could inhibit MK differentiation and platelet biogenesis and might be an agent for thrombocythemia. (Courtesy of Dr. Jie Jin. See pages 416-428 by Jiansong Huang et al. for more information.)
2022,16 (2)
Dysregulated gut microbiome might alter the basal immune status of patients with COVID-19 and thereby influence the severity of the COVID-19. (Courtesy of Drs. Yun Tan and Saijuan Chen. See pages 263-275 by Xiaoguang Xu et al. for more information.)
Dysregulated gut microbiome might alter the basal immune status of patients with COVID-19 and thereby influence the severity of the COVID-19. (Courtesy of Drs. Yun Tan and Saijuan Chen. See pages 263-275 by Xiaoguang Xu et al. for more information.)
2022,16 (1)
Synapse formation was demonstrated by the fluorescence overlap with strong signal on the B/T cell interface, indicating CD3/CD19 bispecifc antibodies are capable of simultaneously engaging T cells and B cells in order to redirect T cells for the B-cell cytotoxicity. (Courtesy of Drs. Jin Wang, Xiaoqiang Yan, and Jian-Qing Mi. See pages 139-149 by Sisi Wang et al. for more information.)
Synapse formation was demonstrated by the fluorescence overlap with strong signal on the B/T cell interface, indicating CD3/CD19 bispecifc antibodies are capable of simultaneously engaging T cells and B cells in order to redirect T cells for the B-cell cytotoxicity. (Courtesy of Drs. Jin Wang, Xiaoqiang Yan, and Jian-Qing Mi. See pages 139-149 by Sisi Wang et al. for more information.)
2021,15 (6)
The hypometabolism pattern of hypothalamic hamartoma patients. (Courtesy of Drs. Yongzhi Shan, Penghu Wei, and Guoguang Zhao. See pages 913-921 by Chao Lu et al. for more information.)
The hypometabolism pattern of hypothalamic hamartoma patients. (Courtesy of Drs. Yongzhi Shan, Penghu Wei, and Guoguang Zhao. See pages 913-921 by Chao Lu et al. for more information.)
2021,15 (5)
SHL oral liquid, a traditional Chinese patent medicine containing extracts of three herbs, including Lonicera japonica Thunb., Scutellaria baicalensis Georgi, and Forsythia suspense (Thunb.), used in combination with standard care was safe and partially effective for the treatment of COVID-19. The crystal structure reveals the inhibition mechanism of baicalein, a bioactive ingredient of SHL, to the main protease (Mpro) of SARS-CoV-2. (Courtesy of Drs. Yechun Xu and Hualiang Jiang. See pages 704-717 by Li Ni et al. for more information.)
SHL oral liquid, a traditional Chinese patent medicine containing extracts of three herbs, including Lonicera japonica Thunb., Scutellaria baicalensis Georgi, and Forsythia suspense (Thunb.), used in combination with standard care was safe and partially effective for the treatment of COVID-19. The crystal structure reveals the inhibition mechanism of baicalein, a bioactive ingredient of SHL, to the main protease (Mpro) of SARS-CoV-2. (Courtesy of Drs. Yechun Xu and Hualiang Jiang. See pages 704-717 by Li Ni et al. for more information.)
2021,15 (4)
Schematic figure of the characteristics for CD34+CD117dim/CD34+CD117bri myeloblasts in t(8;21) AML. (Courtesy of Dr. Lu Jiang. See pages 608-620 by Xueping Li et al. for more information.)
Schematic figure of the characteristics for CD34+CD117dim/CD34+CD117bri myeloblasts in t(8;21) AML. (Courtesy of Dr. Lu Jiang. See pages 608-620 by Xueping Li et al. for more information.)
2021,15 (3)
Immunofluorescent staining of endogenous PHB1 (red) and FKBP8 (green) in SK-OV-3 cells. Nuclei were stained with DAPI (blue). (Courtesy of Dr. Yingjie Xu. See pages 448-459 by Jiahui Zhang et al. for more information.)
Immunofluorescent staining of endogenous PHB1 (red) and FKBP8 (green) in SK-OV-3 cells. Nuclei were stained with DAPI (blue). (Courtesy of Dr. Yingjie Xu. See pages 448-459 by Jiahui Zhang et al. for more information.)
