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Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive cases |
Lulu Ma, Wei Liu, Yuguang Huang() |
Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China |
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Abstract Pregnancy with pulmonary hypertension is considered to be associated with increased maternal and neonatal mortality. We retrospectively reviewed all parturients with pulmonary hypertension who registered at our hospital between 1999 and December 2008. We collected information about patient characteristics, including maternal age, gravida and para, pulmonary hypertension category, New York Heart Association (NYHA) functional class, pulmonary artery pressure, mode of delivery and type of anesthesia, use of anticoagulation and advanced therapy (nitric oxide, prostacyclin analogus, bosentan or sildenafil). The overall maternal mortality was 16.7% in puerperium, and there were four fetal/neonatal deaths (13%). Logistic regression could not identify any factors, including modes of anesthesia, mode of delivery, and categories and severity of pulmonary hypertension, that were significant predictors of mortality. Maternal mortality in parturients with pulmonary hypertension is high and women with pulmonary hypertension who become pregnant warrant a multidisciplinary approach.
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Keywords
pulmonary hypertension
pregnancy
anesthesia
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Corresponding Author(s):
Huang Yuguang,Email:pumchhyg@yahoo.com.cn
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Issue Date: 05 September 2012
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1 |
Gaine SP, Rubin LJ. Primary pulmonary hypertension. Lancet 1998; 352(9129): 719–725 doi: 10.1016/S0140-6736(98)02111-4 pmid:9729004
|
2 |
Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004; 351(14): 1425–1436 doi: 10.1056/NEJMra040291 pmid:15459304
|
3 |
Weiss BM, Hess OM. Pulmonary vascular disease and pregnancy: current controversies, management strategies, and perspectives. Eur Heart J 2000; 21(2): 104–115 doi: 10.1053/euhj.1999.1701 pmid:10637084
|
4 |
Warnes CA. Pregnancy and pulmonary hypertension. Int J Cardiol 2004; 97(Suppl 1): 11–13 doi: 10.1016/j.ijcard.2004.08.004 pmid:15590074
|
5 |
Weiss BM, Zemp L, Seifert B, Hess OM. Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996. J Am Coll Cardiol 1998; 31(7): 1650–1657 doi: 10.1016/S0735-1097(98)00162-4 pmid:9626847
|
6 |
Yentis SM, Steer PJ, Plaat F. Eisenmenger’s syndrome in pregnancy: maternal and fetal mortality in the 1990s. Br J Obstet Gynaecol 1998; 105(8): 921–922 doi: 10.1111/j.1471-0528.1998.tb10240.x pmid:9746388
|
7 |
Simonneau G, Galiè N, Rubin LJ, Langleben D, Seeger W, Domenighetti G, Gibbs S, Lebrec D, Speich R, Beghetti M, Rich S, Fishman A. Clinical classification of pulmonary hypertension. J Am Coll Cardiol 2004; 43(12 Suppl): S5–S 12 doi: 10.1016/j.jacc.2004.02.037 pmid:15194173
|
8 |
Gleicher N, Midwall J, Hochberger D, Jaffin H. Eisenmenger’s syndrome and pregnancy. Obstet Gynecol Surv 1979; 34(10): 721–741 doi: 10.1097/00006254-197910000-00001 pmid:503376
|
9 |
Curry RA, Fletcher C, Gelson E, Gatzoulis MA, Woolnough M, Richards N, Swan L, Steer PJ, Johnson MR. Pulmonary hypertension and pregnancy—a review of 12 pregnancies in nine women. BJOG 2012; 119(6): 752–761 doi: 10.1111/j.1471-0528.2012.03295.x pmid:22390684
|
10 |
Ghai B, Mohan V, Khetarpal M, Malhotra N. Epidural anesthesia for cesarean section in a patient with Eisenmenger’s syndrome. Int J Obstet Anesth 2002; 11(1): 44–47 doi: 10.1054/ijoa.2001.9889 pmid:15321575
|
11 |
Olofsson C, Bremme K, Forssell G, Ohqvist G. Cesarean section under epidural ropivacaine 0.75% in a parturient with severe pulmonary hypertension. Acta Anaesthesiol Scand 2001; 45(2): 258–260 doi: 10.1034/j.1399-6576.2001.450220.x pmid:11167175
|
12 |
Diller GP, Gatzoulis MA. Pulmonary vascular disease in adults with congenital heart disease. Circulation 2007; 115(8): 1039–1050 doi: 10.1161/CIRCULATIONAHA.105.592386 pmid:17325254
|
13 |
Steer PJ. Pregnancy and contraception. In: Gatzoulis MA, Swan L, Therrien J, Pantely GA. Adult Congenital Heart Disease: A Practical Guide . Oxford: BMJ Publishing, Blackwell Publishing, 2005:16–35
|
14 |
Bédard E, Dimopoulos K, Gatzoulis MA. Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension? Eur Heart J 2009; 30(3): 256–265 doi: 10.1093/eurheartj/ehn597 pmid:19147605
|
15 |
Monnery L, Nanson J, Charlton G. Primary pulmonary hypertension in pregnancy; a role for novel vasodilators. Br J Anaesth 2001; 87(2): 295–298 doi: 10.1093/bja/87.2.295 pmid:11493507
|
16 |
Coskun D, Mahli A, Korkmaz S, Demir FS, Inan GK, Erer D, Ozdogan ME. Anaesthesia for caesarean section in the presence of multivalvular heart disease and severe pulmonary hypertension: a case report. Cases J 2009; 2(1): 9383 doi: 10.1186/1757-1626-2-9383 pmid:20072681
|
17 |
Robinson DE, Leicht CH. Epidural analgesia with low-dose bupivacaine and fentanyl for labor and delivery in a parturient with severe pulmonary hypertension. Anesthesiology 1988; 68(2): 285–288 doi: 10.1097/00000542-198802000-00020 pmid:3341585
|
18 |
Khan MJ, Bhatt SB, Kryc JJ. Anesthetic considerations for parturients with primary pulmonary hypertension: review of the literature and clinical presentation. Int J Obstet Anesth 1996; 5(1): 36–42 doi: 10.1016/S0959-289X(96)80072-0 pmid:15321380
|
19 |
Rimaitis K, Aliu?kevi?ien? A, Adukauskien? D, Rimaitis M, Macas A. Cesarean delivery in severe pulmonary hypertension: a case report. Medicina (Kaunas) 2012; 48(3): 159–162 pmid:22588348
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