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Frontiers of Medicine

ISSN 2095-0217

ISSN 2095-0225(Online)

CN 11-5983/R

Postal Subscription Code 80-967

2018 Impact Factor: 1.847

Front Med    2012, Vol. 6 Issue (3) : 307-310    https://doi.org/10.1007/s11684-012-0209-3
RESEARCH ARTICLE
Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive cases
Lulu Ma, Wei Liu, Yuguang Huang()
Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
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Abstract

Pregnancy with pulmonary hypertension is considered to be associated with increased maternal and neonatal mortality. We retrospectively reviewed all parturients with pulmonary hypertension who registered at our hospital between 1999 and December 2008. We collected information about patient characteristics, including maternal age, gravida and para, pulmonary hypertension category, New York Heart Association (NYHA) functional class, pulmonary artery pressure, mode of delivery and type of anesthesia, use of anticoagulation and advanced therapy (nitric oxide, prostacyclin analogus, bosentan or sildenafil). The overall maternal mortality was 16.7% in puerperium, and there were four fetal/neonatal deaths (13%). Logistic regression could not identify any factors, including modes of anesthesia, mode of delivery, and categories and severity of pulmonary hypertension, that were significant predictors of mortality. Maternal mortality in parturients with pulmonary hypertension is high and women with pulmonary hypertension who become pregnant warrant a multidisciplinary approach.

Keywords pulmonary hypertension      pregnancy      anesthesia     
Corresponding Author(s): Huang Yuguang,Email:pumchhyg@yahoo.com.cn   
Issue Date: 05 September 2012
 Cite this article:   
Yuguang Huang,Lulu Ma,Wei Liu. Perioperative management for parturients with pulmonary hypertension: experience with 30 consecutive cases[J]. Front Med, 2012, 6(3): 307-310.
 URL:  
https://academic.hep.com.cn/fmd/EN/10.1007/s11684-012-0209-3
https://academic.hep.com.cn/fmd/EN/Y2012/V6/I3/307
Idiopathic pulmonary hypertensionSecondary pulmonary hypertension
(n = 8)Congenital heart disease(n = 7)Rheumatic heart disease(n = 10)Other etiology(n = 5)
Age (year)28 (22-37)27 (24-31)28 (21-37)31(27-35)
NYHA class pre-pregnancyI/IIIII/IV8/-- / -3/4- / -7/21/-4/-1/-
NYHA class during pregnancyI/IIIII/IV4/1-/3- / -4/12/23/3-/21/2
Pulmonary artery pressure
Mild (25-49 mmHg)71-2
Moderate (50-79 mmHg)1242
Severe (>80 mmHg)-461
Heart failure
During pregnancy3163
During labor-231
Postpartum-11-
Mode of delivery
Caesarean section86105
Vaginal-1--
Anesthetic technique
Neuraxial anesthesia7263
General anesthesia1442
Antithrombotic therapy
During pregnancy--31
Postpartum2241
Advanced therapy*-2--
Maternal death (early postpartum)-32-
Premature delivery4444
Neonatal death-3-1
Tab.1  Characteristics, management and outcome of parturients with pulmonary hypertension
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