Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

doi:10.1007/s11684-020-0773-x

Front. Med.

2020, Vol. 14

Issue (2) : 117-125 https://doi.org/10.1007/s11684-020-0773-x

REVIEW

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou¹(

), Saijuan Chen², Zhu Chen²(

)

¹. State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
². State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine (Shanghai), Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

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Abstract

Since the outbreak of the COVID-19 pandemic in early December 2019, 81 174 confirmed cases and 3242 deaths have been reported in China as of March 19, 2020. The Chinese people and government have contributed huge efforts to combat this disease, resulting in significant improvement of the situation, with 58 new cases (34 were imported cases) and 11 new deaths reported on March 19, 2020. However, as of March 19, 2020, the COVID-19 pandemic continues to develop in 167 countries/territories outside of China, and 128 665 confirmed cases and 5536 deaths have been reported, with 16 498 new cases and 817 new deaths occurring in last 24 hours. Therefore, the world should work together to fight against this pandemic. Here, we review the recent advances in COVID-19, including the insights in the virus, the responses of the host cells, the cytokine release syndrome, and the therapeutic approaches to inhibit the virus and alleviate the cytokine storm. By sharing knowledge and deepening our understanding of the virus and the disease pathogenesis, we believe that the community can efficiently develop effective vaccines and drugs, and the mankind will eventually win this battle against this pandemic.

Keywords COVID-19 SARS-CoV-2 pathogenesis evidence-based medicine control and therapeutic strategies

Corresponding Author(s): Guangbiao Zhou,Zhu Chen

Just Accepted Date: 21 March 2020 Online First Date: 20 April 2020 Issue Date: 09 May 2020

Cite this article:

Guangbiao Zhou,Saijuan Chen,Zhu Chen. Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies[J]. Front. Med., 2020, 14(2): 117-125.

URL:

https://academic.hep.com.cn/fmd/EN/10.1007/s11684-020-0773-x
https://academic.hep.com.cn/fmd/EN/Y2020/V14/I2/117

Fig.1 The putative life cycle of SARS-CoV-2.

Fig.2 Cytokine storm and related symptoms of COVID-19.

Tab.1 Clinical features of CRS

Fig.3 SARS-CoV-2-induced injury and failure of the lungs, and therapeutic strategies against COVID-19. ARDS, acute respiratory distress syndrome.

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