Piezoelectric pump with flexible venous valves for active cell transmission

doi:10.1007/s11465-022-0712-4

Frontiers of Mechanical Engineering

2022, Vol. 17

Issue (4): 56 https://doi.org/10.1007/s11465-022-0712-4

本期目录

Piezoelectric pump with flexible venous valves for active cell transmission

Jun HUANG¹, Jiaming LIU¹, Kai LI², Lei ZHANG³, Quan ZHANG⁴(

), Yuan WANG⁵

¹. Research Center of Fluid Machinery Engineering and Technology, Jiangsu University, Zhenjiang 212013, China
². Research and Development Center of New Combined Power, Shaanxi Province Aerospace and Astronautics Propulsion Research Institute Co., Ltd., Xi’an 710076, China
³. School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, China
⁴. School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200072, China
⁵. College of Communication Engineering, Army Engineering University of PLA, Nanjing 210007, China

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Abstract：

The development of organ-on-a-chip systems demands high requirements for adequate micro-pump performance, which needs excellent performance and effective transport of active cells. In this study, we designed a piezoelectric pump with a flexible venous valve inspired by that of humans. Performance test of the proposed pump with deionized water as the transmission medium shows a maximum output flow rate of 14.95 mL/min when the input voltage is 100 V, and the pump can transfer aqueous solutions of glycerol with a viscosity of 10.8 mPa·s. Cell survival rate can reach 97.22% with a yeast cell culture solution as the transmission medium. A computational model of the electric-solid-liquid multi-physical field coupling of the piezoelectric pump with a flexible venous valve is established, and simulation results are consistent with experimental results. The proposed pump can help to construct the circulating organ-on-a-chip system, and the simple structure and portable application can enrich the design of microfluidic systems. In addition, the multi-physical field coupling computational model established for the proposed piezoelectric pump can provide an in-depth study of the characteristics of the flow field, facilitating the optimal design of the micro-pump and providing a reference for the further study of active cell transport in organ-on-a-chip systems.

Key words： venous valve flexible venous valve cell transmission organ-on-a-chip system piezoelectric device

收稿日期: 2021-12-25 出版日期: 2022-12-25

Corresponding Author(s): Quan ZHANG

引用本文:

. [J]. Frontiers of Mechanical Engineering, 2022, 17(4): 56.
Jun HUANG, Jiaming LIU, Kai LI, Lei ZHANG, Quan ZHANG, Yuan WANG. Piezoelectric pump with flexible venous valves for active cell transmission. Front. Mech. Eng., 2022, 17(4): 56.

链接本文:

https://academic.hep.com.cn/fme/CN/10.1007/s11465-022-0712-4
https://academic.hep.com.cn/fme/CN/Y2022/V17/I4/56

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Material	Young’s modulus/GPa	Piezoelectric constant/(C?m⁻²)	Permittivity/(F?m⁻¹)	Poisson’s ratio	Density/(kg?m^?3)
Beryllium bronze	128	?	?	0.35	8600
PZT-5A	$[121 75.4 75.2 000 75.4 121 75.2 000 75.2 75.2 111000 000 21.1 00 0000 21.1 0 00000 22.6]$	$[00 − 5.4 00 − 5.4 00 15.8 0 12.3 0 12.3 00 000]$	$[8.107 00 0 8.107 0 00 7.346] × 10 − 9$	?	7750

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