The objective of this study was to develop an adaptive thermal comfort equation for naturally ventilated buildings in hot-humid climates. The study employed statistical meta-analysis of the American Society of Heating, Refrigerating and Air-Conditioning Engineers (ASHRAE) RP-884 database, which covered several climatic zones. The data were carefully sorted into three climate groups including hot-humid, hot-dry, and moderate and were analyzed separately. The results revealed that the adaptive equations for hot-humid and hot-dry climates were analogous with approximate regression coefficients of 0.6, which were nearly twice those of ASHRAE and European standards 55 and EN15251, respectively. The equation using the daily mean outdoor air temperature had the highest coefficient of determination for hot-humid climate, compared with other mean temperatures that considered acclimatization of previous days. Acceptable comfort ranges showed asymmetry and leaned toward operative temperatures below thermal neutrality for all climates. In the hot-humid climate, a lower comfort limit was not observed for naturally ventilated buildings, and the adaptive equation was influenced by indoor air speed rather than indoor relative humidity. The new equation developed in this study can be applied to tropical climates and hot-humid summer seasons of temperate climates.