Differential absorption optical coherence tomography with strong absorption contrast agents of gold nanorods

doi:10.1007/s12200-009-0012-1

Front Optoelec Chin

2009, Vol. 2

Issue (2) : 141-145 https://doi.org/10.1007/s12200-009-0012-1

RESEARCH ARTICLE

Differential absorption optical coherence tomography with strong absorption contrast agents of gold nanorods

Ming WEI, Jun QIAN, Qiuqiang ZHAN, Fuhong CAI, Arash GHARIBI, Sailing HE(

)

Centre for Optical and Electromagnetic Research, Joint Research Center of Photonics of the Royal Institute of Technology (Sweden) and Zhejiang University, Zhejiang University, Hangzhou 310058, China

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Abstract

Plasmon-resonant gold nanorods (GNRs) are demonstrated as strong absorption contrast agents for optical coherence tomography (OCT). OCT imaging of tissue phantoms doped with GNRs of different resonant wavelengths and concentrations is studied. To utilize the high absorption property of GNRs, a differential absorption OCT imaging is introduced to retrieve the absorption information of GNRs from conventional backscattered signals. It is shown that the contrast of the OCT image can be enhanced significantly when the plasmon resonant wavelength of the GNRs matches the central wavelength of the OCT source.

Keywords optical coherence tomography (OCT) plasmon resonance gold nanorod (GNR) differential absorption

Corresponding Author(s): HE Sailing,Email:sailing@kth.se

Issue Date: 05 June 2009

Cite this article:

Qiuqiang ZHAN,Ming WEI,Fuhong CAI, et al. Differential absorption optical coherence tomography with strong absorption contrast agents of gold nanorods[J]. Front Optoelec Chin, 2009, 2(2): 141-145.

URL:

https://academic.hep.com.cn/foe/EN/10.1007/s12200-009-0012-1
https://academic.hep.com.cn/foe/EN/Y2009/V2/I2/141

Fig.1 TEM pictures of GNRs with longitudinal resonant peak at (a) 945 nm and (b) 666 nm (scale bars are 100 nm), and (c) extinction spectra of these two GNRs samples [solid line: GNRs shown in (a); dashed line: GNRs shown in (b)]

Fig.2 Setup of time-domain OCT system

Fig.3

Fig.4 (a) Cross-sectional OCT images of tissue phantom doped with GNRs with resonance at 945 nm. Concentrations of GNRs in different parts of phantom (from left to right) are: 8 pmol/mL (Part 1), 5 pmol/mL (Part 2), and 0 (Part 3); (b) cross-sectional OCT images of tissue phantom doped with GNRs with resonance at 666 nm. Concentrations of GNRs are the same as those in (a), vertical scale bars are 200 μm; (c) demodulated OCT intensities decay with their best-fit lines (dashed lines) for different concentrations of GNRs used in (a)

Fig.5

Fig.6 Conventional OCT signals of two-layer phantom indicative of (a) backscattered intensity (the two layers are separated in a red solid line) and (b) differential absorption signal (the layer inside the square of the image is phantom doped with GNRs resonant at 945 nm at a concentration of 2 pmol/mL, scale bars are 200 μm); (c) demodulated OCT intensity decay with their best-fit lines (dashed lines) of phantom with TiO only

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