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Diagnostics of bronchopulmonary diseases through Mahalanobis distance-based absorption spectral analysis of exhaled air |
A. A. BULANOVA1,*(),E. B. BUKREEVA1,Yu. V. KISTENEV1,2,O. Yu. NIKIFOROVA3 |
1. Siberian State Medical University, Tomsk 634050, Russia 2. Tomsk State University, Tomsk 634050, Russia 3. V.E. Zuev Institute of Atmospheric Optics SB RAS, Tomsk 634055, Russia |
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Abstract Accurate diagnosis of different bronchopulmonary diseases is important in clinical practice. This study involved 20 healthy volunteers and 77 patients with bronchopulmonary diseases, including chronic obstructive pulmonary disease (COPD), bronchial asthma, pulmonary tuberculosis, and community-acquired pneumonia. The absorption spectrum of exhaled air samples was recorded on an intra-cavity photo-acoustic gas analyzer (ILPA-1, Special Technologies, Ltd., Russia) with photo-acoustic detectors and CO2 laser with a tuning range from 9.2 to 10.8 μm. In conclusion, analysis of the Mahalanobis distance-based absorption spectral profiles of breath air from bronchopulmonary patients and healthy volunteers allows the formulation of a preliminary diagnosis.
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Keywords
bronchopulmonary diseases
exhaled air
Mahalanobis distance
laser photo-acoustic spectroscopy
CO2 laser
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Corresponding Author(s):
A. A. BULANOVA
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Just Accepted Date: 15 May 2015
Issue Date: 24 June 2015
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