Line-field confocal optical coherence tomography for three-dimensional skin imaging

doi:10.1007/s12200-020-1096-x

Front. Optoelectron.

2020, Vol. 13

Issue (4) : 381-392 https://doi.org/10.1007/s12200-020-1096-x

RESEARCH ARTICLE

Line-field confocal optical coherence tomography for three-dimensional skin imaging

Jonas OGIEN¹, Anthony DAURES¹, Maxime CAZALAS¹, Jean-Luc PERROT², Arnaud DUBOIS³(

)

¹. DAMAE Medical, Paris 75013, France
². CHU St-Etienne, Service Dermatologie, Saint-Etienne 42055, France
³. Université Paris-Saclay, Institut d’Optique Graduate School, CNRS, Laboratoire Charles Fabry, Palaiseau 91127, France

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Abstract

This paper reports on the latest advances in line-field confocal optical coherence tomography (LC-OCT), a recently invented imaging technology that now allows the generation of either horizontal (x× y) section images at an adjustable depth or vertical (x× z) section images at an adjustable lateral position, as well as three-dimensional images. For both two-dimensional imaging modes, images are acquired in real-time, with real-time control of the depth and lateral positions. Three-dimensional (x× y× z) images are acquired from a stack of horizontal section images. The device is in the form of a portable probe. The handle of the probe has a button and a scroll wheel allowing the user to control the imaging modes. Using a supercontinuum laser as a broadband light source and a high numerical microscope objective, an isotropic spatial resolution of ~1 mm is achieved. The field of view of the three-dimensional images is 1.2 mm × 0.5 mm × 0.5 mm (x× y× z). Images of skin tissues are presented to demonstrate the potential of the technology in dermatology.

Keywords optical coherence tomography (OCT) microscopy three-dimensional imaging dermatology

Corresponding Author(s): Arnaud DUBOIS

Just Accepted Date: 20 November 2020 Online First Date: 14 December 2020 Issue Date: 31 December 2020

Cite this article:

Jonas OGIEN,Anthony DAURES,Maxime CAZALAS, et al. Line-field confocal optical coherence tomography for three-dimensional skin imaging[J]. Front. Optoelectron., 2020, 13(4): 381-392.

URL:

https://academic.hep.com.cn/foe/EN/10.1007/s12200-020-1096-x
https://academic.hep.com.cn/foe/EN/Y2020/V13/I4/381

Fig.1 Schematic diagram of the latest LC-OCT prototype

Fig.2 LC-OCT probe and cart used by a dermatologist in a clinical setting

Fig.3 Periodic current driving the oscillation of the PZT stage. The asymmetric triangle signal has a frequency of

f PZT =1/ T =8 ? Hz

and a duty cycle of 80%. Images are acquired only during the slow positive ramps

Fig.4 Periodic current driving the oscillation of the mirror galvanometer. The asymmetric triangle signal has a frequency of

f galvo =1/ T =8 ? Hz

and a duty cycle of 90%. Images are acquired only during the slow positive ramps

Fig.5 LC-OCT images of healthy human skin in vivo obtained in real-time (8 frames/s). Horizontal section images obtained at the level of the stratum spinosum (a), the stratum basale (b) and the superficial dermis (c). A vertical section image is also displayed (d). Scale bars are 200 µm

Fig.6 Three-dimensional volume rendering of in vivo human healthy skin, digitally “cut” at different depths

Fig.7 (a) Vertical and horizontal cross-section images obtained from a three-dimensional LC-OCT image. (b) Three-dimensional visualization from vertical and horizontal cross-section images

Fig.8 Three-dimensional visualization of sweat ducts of the palm of the hand from application of a maximum intensity projection to a three-dimensional LC-OCT image

Fig.9 Three-dimensional visualization of capillaries of the nailfold from application of a minimum intensity projection to a three-dimensional LC-OCT image

Fig.10 Skin layers segmentation of a three-dimensional LC-OCT image. The green volume corresponds to the segmented epidermis, while the purple volume corresponds to the dermis

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