Abstract：Biomolecule sensitive hydrogel, as an important part of intelligent materials, has extensive applications in the biochemical and biomedical fields. In this paper, an antigen sensitive degradable hydrogel based on hyaluronic acid (HA) has been prepared. Antigen and antibody were covalently attached to the hydrogel simultaneous, while HA was cross-linked used adipic dihydrazide (ADH) as cross-linking agent primarily. We describe the synthesis, characteristics, and the antigen sensitive behavior of the hydrogel. The hydrogel can exhibit a reversible swelling behavior while the native antigen is present or not. This property of the antigen sensitive hydrogel may be applied as novel drug delivery system, which can release drug by the presence of native antigen.
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