Cancer cell proliferation controlled by surface chemistry in its microenvironment
Cancer cell proliferation controlled by surface chemistry in its microenvironment
Xiao-Long YU1, Bin ZHANG2, Xiu-Mei WANG1, Ying WANG1, Lin QIAO1, Jin HE1, Juan WANG2, Shuang-Feng CHEN2, In-Seop LEE3, Fu-Zhai CUI1()
1. Institute of Regenerative and Biomimetic Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China; 2. Liaocheng People’s Hospital, Liaocheng 252000, China; 3. Atomic-Scale Surface Science Research Center, Yonsei University, Seoul 120-749, Korea
Hepatoma cells (Hepg2s) as typical cancer cells cultured on hydroxyl (-OH) and methyl (-CH3) group surfaces were shown to exhibit different proliferation and morphological changes. Hepg2s cells on -OH surfaces grew much more rapidly than those on -CH3 surfaces. Hepg2s cells on -OH surfaces had the larger contact area and the more flattened morphology, while those on -CH3 surfaces exhibited the smaller contact area and the more rounded morphology. After 7 days of culture, the migration of Hepg2s cells into clusters on the -CH3 surfaces behaved significantly slower than that on the -OH surfaces. These chemically modified surfaces exhibited regulation of Hepg2s cells on proliferation, adhesion, and migration, providing a potential treatment of liver cancer.
Corresponding Author(s):
CUI Fu-Zhai,Email:cuifz@mail.tsinghua.edu.cn
引用本文:
. Cancer cell proliferation controlled by surface chemistry in its microenvironment[J]. Frontiers of Materials Science, 2011, 5(4): 412-416.
Xiao-Long YU, Bin ZHANG, Xiu-Mei WANG, Ying WANG, Lin QIAO, Jin HE, Juan WANG, Shuang-Feng CHEN, In-Seop LEE, Fu-Zhai CUI. Cancer cell proliferation controlled by surface chemistry in its microenvironment. Front Mater Sci, 2011, 5(4): 412-416.
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