Heat preservation, antifouling, hemostatic and antibacterial aerogel wound dressings for emergency treatment
Fangling Li1,2, Xiaoman Han3, Dongdong Cao4, Junxia Yin1,2, Li Chen1,2, Dongmei Li4, Lin Cui4, Zhiyong Liu1,2(), Xuhong Guo1,2,5()
1. School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China 2. Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, Shihezi 832003, China 3. School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024, China 4. School of Medicine, Shihezi University, Shihezi 832003, China 5. State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
Hemostatic dressings with multiple functions are superior to current hemostatic dressings for use in the complex situation of emergency accidents. In particular, the existing dressings lack consideration for the prevention of hypothermic shock after massive hemorrhage. In this study, gelatin (GN) and oxidized pectin (OP) were used for Schiff base cross-linking, and then polyvinyl alcohol (PVA) solution mixed with hemostatic caffeic acid (CA) was introduced to obtain aerogel substrate material (CB) after lyophilization. Polydimethylsiloxane (PDMS) and silver nanowires (Ag NWs) were used to construct a hydrophobic layer, an antibacterial layer and an infrared reflective layer on both sides of CB to prepare a multifunctional aerogel wound dressing with heat preservation, antifouling, hemostasis and antibacterial properties (PDMS-Ag NW-CB). The results showed that the infrared transmittance of PDMS-Ag NW-CB is almost 0, so that thermal energy loss from the body is minimized. The contact angles with water and blood are 129° and 120°, respectively, which have the effect of antifouling. This dressing can absorb blood quickly within 10 min, adhere to and gather platelets, and achieve hemostasis. It has good antibacterial and biocompatibility. Therefore, PDMS-Ag NW-CB has great potential in application to emergency treatment.
Y, Ma J, Yao Q, Liu et al.. Liquid bandage harvests robust adhesive, hemostatic, and antibacterial performances as a first-aid tissue adhesive.Advanced Functional Materials, 2020, 30(39): 2001820 https://doi.org/10.1002/adfm.202001820
2
Y, Hao C, Yuan J, Deng et al.. Injectable self-healing first-aid tissue adhesives with outstanding hemostatic and antibacterial performances for trauma emergency care.ACS Applied Materials & Interfaces, 2022, 14(14): 16006–16017 https://doi.org/10.1021/acsami.2c00877
pmid: 35378035
3
Y, Liang H, Xu Z, Li et al.. Bioinspired injectable self-healing hydrogel sealant with fault-tolerant and repeated thermo-responsive adhesion for sutureless post-wound-closure and wound healing.Nano-Micro Letters, 2022, 14(1): 185 https://doi.org/10.1007/s40820-022-00928-z
pmid: 36098823
4
S Y, Jiang Y Y, Zhao X G Zhao . Potential role of therapeutic hypothermia in the salvage of traumatic hemorrhagic shock.Critical Care, 2013, 17(3): 318 https://doi.org/10.1186/cc12559
pmid: 23714428
5
S, Pourshahrestani E, Zeimaran N A, Kadri et al.. Polymeric hydrogel systems as emerging biomaterial platforms to enable hemostasis and wound healing.Advanced Healthcare Materials, 2020, 9(20): 2000905 https://doi.org/10.1002/adhm.202000905
pmid: 32940025
C, Cui C, Fan Y, Wu et al.. Water-triggered hyperbranched polymer universal adhesives: from strong underwater adhesion to rapid sealing hemostasis.Advanced Materials, 2019, 31(49): 1905761 https://doi.org/10.1002/adma.201905761
pmid: 31625635
8
S, Baghdasarian B, Saleh A, Baidya et al.. Engineering a naturally derived hemostatic sealant for sealing internal organs.Materials Today Bio, 2022, 13: 100199 https://doi.org/10.1016/j.mtbio.2021.100199
pmid: 35028556
9
G, Xi W, Liu M, Chen et al.. Polysaccharide-based lotus seedpod surface-like porous microsphere with precise and controllable micromorphology for ultrarapid hemostasis.ACS Applied Materials & Interfaces, 2019, 11(50): 46558–46571 https://doi.org/10.1021/acsami.9b17543
pmid: 31769962
10
C, Yan T, Yang S, Zhu et al.. Synthesis and properties of poly(DEX-GMA/AAc) microgel particle as a hemostatic agent.Journal of Materials Chemistry B: Materials for Biology and Medicine, 2017, 5(20): 3697–3705 https://doi.org/10.1039/C7TB00768J
pmid: 32264058
11
J, Jin M, Xu Y, Liu et al.. Alginate-based composite microspheres coated by berberine simultaneously improve hemostatic and antibacterial efficacy.Colloids and Surfaces B: Biointerfaces, 2020, 194: 111168 https://doi.org/10.1016/j.colsurfb.2020.111168
pmid: 32563918
12
X, Xie D, Li Y, Chen et al.. Conjugate electrospun 3D gelatin nanofiber sponge for rapid hemostasis.Advanced Healthcare Materials, 2021, 10(20): 2100918 https://doi.org/10.1002/adhm.202100918
pmid: 34235873
13
Z, Xu L, Zou F, Xie et al.. Biocompatible carboxymethyl chitosan/GO-based sponge to improve the efficiency of hemostasis and wound healing.ACS Applied Materials & Interfaces, 2022, 14(39): 44799–44808 https://doi.org/10.1021/acsami.2c09309
pmid: 36150074
14
H T, Beaman E, Shepherd J, Satalin et al.. Hemostatic shape memory polymer foams with improved survival in a lethal traumatic hemorrhage model.Acta Biomaterialia, 2022, 137: 112–123 https://doi.org/10.1016/j.actbio.2021.10.005
pmid: 34655799
15
D, Chen X, Zhou L, Chang et al.. Hemostatic self-healing hydrogel with excellent biocompatibility composed of polyphosphate-conjugated functional PNIPAM-bearing acylhydrazide.Biomacromolecules, 2021, 22(5): 2272–2283 https://doi.org/10.1021/acs.biomac.1c00349
pmid: 33905651
16
Y, Yang Y, Liang J, Chen et al.. Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing.Bioactive Materials, 2022, 8: 341–354 https://doi.org/10.1016/j.bioactmat.2021.06.014
pmid: 34541405
17
M, Li Z, Zhang Y, Liang et al.. Multifunctional tissue-adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair.ACS Applied Materials & Interfaces, 2020, 12(32): 35856–35872 https://doi.org/10.1021/acsami.0c08285
pmid: 32805786
18
Q, Yan X, Long P, Zhang et al.. Oxidized Bletilla rhizome polysaccharide-based aerogel with synergistic antibiosis and hemostasis for wound healing.Carbohydrate Polymers, 2022, 293: 119696 https://doi.org/10.1016/j.carbpol.2022.119696
pmid: 35798416
19
C, Lv X, Zhou P, Wang et al.. Antibacterial microspheres with a bionic red-blood-cell like hollow structure and superior swelling recovery capacity for efficient traumatic hemostasis.Applied Materials Today, 2022, 29: 101559 https://doi.org/10.1016/j.apmt.2022.101559
20
D A, Hickman C L, Pawlowski U D S, Sekhon et al.. Biomaterials and advanced technologies for hemostatic management of bleeding.Advanced Materials, 2018, 30(4): 1700859 https://doi.org/10.1002/adma.201700859
pmid: 29164804
S, Jiang X, He J, Wang et al.. Therapeutic mild hypothermia improves early outcomes in rabbits subjected to traumatic uncontrolled hemorrhagic shock.Journal of Surgical Research, 2013, 179(1): 145–152 https://doi.org/10.1016/j.jss.2012.09.024
pmid: 23046717
23
B, Zhou G, Wang N, Peng et al.. Pre-hospital induced hypothermia improves outcomes in a pig model of traumatic hemorrhagic shock.Advances in Clinical and Experimental Medicine, 2015, 24(4): 571–578 https://doi.org/10.17219/acem/29044
pmid: 26469100
24
O, Henriksson J P, Lundgren K, Kuklane et al.. Protection against cold in prehospital care-thermal insulation properties of blankets and rescue bags in different wind conditions.Prehospital and Disaster Medicine, 2009, 24(5): 408–415 https://doi.org/10.1017/S1049023X00007238
pmid: 20066643
25
Q, Gao T, Lauster B A F, Kopera et al.. Breathable and flexible dual-sided nonwovens with adjustable infrared optical performances for smart textile.Advanced Functional Materials, 2022, 32(5): 2108808 https://doi.org/10.1002/adfm.202108808
26
R, Xu W, Wang D Yu . A novel multilayer sandwich fabric-based composite material for infrared stealth and super thermal insulation protection.Composite Structures, 2019, 212: 58–65 https://doi.org/10.1016/j.compstruct.2019.01.032
27
L, Li M, Shi X, Liu et al.. Ultrathin titanium carbide (MXene) films for high-temperature thermal camouflage.Advanced Functional Materials, 2021, 31(35): 2101381 https://doi.org/10.1002/adfm.202101381
28
Q, Huang Y, Zhao Y, Wu et al.. A dual-band transceiver with excellent heat insulation property for microwave absorption and low infrared emissivity compatibility.Chemical Engineering Journal, 2022, 446(4): 137279 https://doi.org/10.1016/j.cej.2022.137279
29
H, Du S, Wang Y, Xing et al.. The dual effect of zirconia fiber on the insulation and mechanical performance of the fumed silica-based thermal insulation material.Ceramics International, 2022, 48(5): 6657–6662 https://doi.org/10.1016/j.ceramint.2021.11.215
30
Q, Liu J, Huang J, Zhang et al.. Thermal, waterproof, breathable, and antibacterial cloth with a nanoporous structure.ACS Applied Materials & Interfaces, 2018, 10(2): 2026–2032 https://doi.org/10.1021/acsami.7b16422
pmid: 29265798
31
H G, Shi H B, Zhao B W, Liu et al.. Multifunctional flame-retardant melamine-based hybrid foam for infrared stealth, thermal insulation, and electromagnetic interference shielding.ACS Applied Materials & Interfaces, 2021, 13(22): 26505–26514 https://doi.org/10.1021/acsami.1c07363
pmid: 34048209
32
L, Lin Y, Choi T, Chen et al.. Superhydrophobic and wearable TPU based nanofiber strain sensor with outstanding sensitivity for high-quality body motion monitoring.Chemical Engineering Journal, 2021, 419: 129513 https://doi.org/10.1016/j.cej.2021.129513
33
W, Zhang L, Lin L, Zhang et al.. An in situ self-assembly dual conductive shell nanofiber strain sensor with superior sensitivity and antibacterial property.Advanced Materials Interfaces, 2022, 9(4): 2101107 https://doi.org/10.1002/admi.202101107
34
W, Zhang S, Piao L, Lin et al.. Wearable and antibacterial HPMC-anchored conductive polymer composite strain sensor with high gauge factors under small strains.Chemical Engineering Journal, 2022, 435: 135068 https://doi.org/10.1016/j.cej.2022.135068
35
H, Yao M, Wu L, Lin et al.. Design strategies for adhesive hydrogels with natural antibacterial agents as wound dressings: status and trends.Materials Today Bio, 2022, 16: 100429 https://doi.org/10.1016/j.mtbio.2022.100429
pmid: 36164504
36
S, Wang W, Zhang J, Yan et al.. Green reduction of graphene oxide by macromolecular CMCS to prepare self-healing conductive hydrogel wound dressing with drug/photothermal antibacterial activity.Macromolecular Materials and Engineering, 2022, 307(7): 2100878 https://doi.org/10.1002/mame.202100878
37
X, Yang D X, Du Y H Wang . Length-dependent electro-optical properties of silver nanowires-based transparent conducting films.Journal of Materials Science: Materials in Electronics, 2019, 30(7): 6838–6845 https://doi.org/10.1007/s10854-019-00996-9
38
H, Zhang X, Sun J, Wang et al.. Multifunctional injectable hydrogel dressings for effectively accelerating wound healing: enhancing biomineralization strategy.Advanced Functional Materials, 2021, 31(23): 2100093 https://doi.org/10.1002/adfm.202100093
39
I, Bayraktar D, Doganay S, Coskun et al.. 3D printed antibacterial silver nanowire/polylactide nanocomposites.Composites Part B: Engineering, 2019, 172: 671–678 https://doi.org/10.1016/j.compositesb.2019.05.059
