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Synthesis of morpholine-2,5-dione derivative copolymer and its degradation in vitro |
| ZHAO Yanchao, CHENG Shujun, CHEN Jianding |
| School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China; |
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Abstract In this experiment we prepared the copolymer of L-lactide (L-LA) and (3s)-[(benzyloxycarbonyl) methyl] morpholine-2,5-dione (BMD) using tin(II)-octanoate initiated ring-opening copolymerization. The maximum relative number-average molecular weight (M n) of copolymer was over 8.0?104. The degradation study proceeded in vitro and poly(L-lactide-co-glycollide) used as the control sample. Changes in mass and molecular weight were studied during the immersion in buffer solutions [phosphate-buffered saline solution (PBS), pH = 7.4] at 37?C. The hydrolytic degradation of both the morpholine-2,5-dione derivative copolymer and the control sample were completed in 3 months. A palladium on charcoal catalyst [Pd/C (5%)] was used as the catalyzer for hydrogenolysis. 1H-NMR (nuclear magnetic resonance) analysis and gel permeation chromatography (GPC) were used to investigate the degree of the hydrogenolysis of the copolymer with different M n. The contact angle showed that the biodegradable copolymer had good hydrophilicity. These findings suggested that this copolymer would have a high potential application for pharmaceutical products.
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Issue Date: 05 June 2007
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