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Preparation of paclitaxel-loaded microspheres with magnetic nanoparticles |
| CUI Sheng1, SHEN Xiaodong1, LIN Benlan1, SHI Ruihua2, CHEN Ping2 |
| 1.College of Materials Science and Technology, Nanjing University of Technology, Nanjing 210009, China; 2.The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China |
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Abstract The objective of this paper was to prepare paclitaxel-loaded microspheres, a kind of target-orientation anticancer drug. The paclitaxel-loaded microspheres were prepared with magnetic Fe3O4 nanoparticles and taxol. The morphology was characterized by scanning electron microscopy (SEM), and the average size and the size distribution were determined by a laser-size distributing instrument. High performance liquid chromatography (HPLC) was used to measure the paclitaxel content. Experimental results indicated that the effective drug loading and the entrapment ratio of paclitaxel-loaded microspheres were 1.83% and 92.62%, respectively.
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Issue Date: 05 December 2007
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