|
|
Fabrication and characterization of hyaluronic-acid-based
antigen sensitive degradable hydrogel |
Yue-teng WEI,Fu-zhai CUI,Wei-ming TIAN, |
Biomaterials Laboratory,
Department of Materials Science and Engineering, Tsinghua University,
Beijing 100084, China; |
|
|
Abstract Biomolecule sensitive hydrogel, as an important part of intelligent materials, has extensive applications in the biochemical and biomedical fields. In this paper, an antigen sensitive degradable hydrogel based on hyaluronic acid (HA) has been prepared. Antigen and antibody were covalently attached to the hydrogel simultaneous, while HA was cross-linked used adipic dihydrazide (ADH) as cross-linking agent primarily. We describe the synthesis, characteristics, and the antigen sensitive behavior of the hydrogel. The hydrogel can exhibit a reversible swelling behavior while the native antigen is present or not. This property of the antigen sensitive hydrogel may be applied as novel drug delivery system, which can release drug by the presence of native antigen.
|
Keywords
intelligent hydrogel
hyaluronic acid
antigen sensitive
|
Issue Date: 05 December 2009
|
|
|
Bonina P, Petrova T, Manolova N, et al. PH-sensitive hydrogels composed of chitosanand polyacrylamide: Enzymatic degradation. Journal of Bioactive and Compatible Polymers, 2004, 19(3): 197―208
doi: 10.1177/0883911504044455
|
|
Chiu H C, Lin Y F, Hsu Y H. Effects of acrylic acid on preparation and swelling propertiesof pH-sensitive dextran hydrogels. Biomaterials, 2002, 23(4): 1103―1112
doi: 10.1016/S0142-9612(01)00222-8
|
|
Mahkam M. Controlledrelease of biomolecules from pH-sensitive hydrogels prepared by radiationpolymerization. Journal of Bioactive andCompatible Polymers, 2004, 19(3): 209―220
doi: 10.1177/0883911504044454
|
|
Mandracchia D, Pitarresi G, Palumbo F S, et al. PH-Sensitive hydrogel based on a novel photocross-linkable. Biomacromolecules, 2004, 5(5): 1973―1982
doi: 10.1021/bm0497567
|
|
Vazquez B, Gurruchaga M, Goni I, et al. A ph-sensitive hydrogel based on poly(ethoxytriethylene glycol monomethacrylate). Polymer, 1995, 36(17): 3327―3333
doi: 10.1016/0032-3861(95)99432-T
|
|
Liu Y Y, Fan X D. Synthesis and characterizationof pH- and temperature-sensitive hydrogel of N-isopropylacrylamide/cyclodextrinbased copolymer. Polymer, 2002, 43(18): 4997―5003
doi: 10.1016/S0032-3861(02)00350-6
|
|
Park T G. Temperature modulated protein release from pH/temperature-sensitivehydrogels. Biomaterials, 1999, 20(6): 517―521
doi: 10.1016/S0142-9612(98)00197-5
|
|
Rathjen C M, Park C H, Goodrich P R, et al. The effect of preparation temperature on someproperties of a temperature-sensitive hydrogel. Polymer Gels and Networks, 1995, 3(2): 101―115
doi: 10.1016/0966-7822(94)00030-B
|
|
van der Linden H, Olthuis W, Bergveld P. An efficient method for the fabrication of temperature-sensitivehydrogel microactuators. Lab Chip, 2004, 4(6): 619―624
doi: 10.1039/b406247g
|
|
Kwon I C, Bae Y H, Kim S W. Electrically credible polymer gel for controlled releaseof drugs. Nature, 1991, 354: 291―293
doi: 10.1038/354291a0
|
|
Tanaka T, Nishio I, Sun S-T, et al. Collapse of gels in an electric field. Science, 1982, 218(4571): 467―469
doi: 10.1126/science.218.4571.467
|
|
Traitel T, Cohen Y, Kost J. Characterization of glucose-sensitive insulin releasesystems in simulated in vivo conditions. Biomaterials, 2000, 21(16): 1679―1687
doi: 10.1016/S0142-9612(00)00050-8
|
|
Miyata T, Asami N, Uragami T. A reversibly antigen-responsive hydrogel. Nature, 1999, 399(6738): 766―769
doi: 10.1038/21619
|
|
Miyata T, Asami N, Uragami T. Preparation of an antigen-sensitive hydrogel using antigen-antibodybindings. Macromolecules, 1999, 32(6): 2082―2084
doi: 10.1021/ma981659g
|
|
Pouyani T, Prestwich G D. Functionalized derivativesof hyaluronic-acid oligosaccharides ― drug carriers and novelbiomaterials. Bioconjugate Chemistry, 1994, 5(4): 339―347
doi: 10.1021/bc00028a010
|
|
Prestwich G D, Marecak D M, Marecek J F, et al. Controlled chemical modification of hyaluronicacid: synthesis, applications, and biodegradation of hydrazide derivatives. Journal of Controlled Release, 1998, 53(1―3): 93―103
doi: 10.1016/S0168-3659(97)00242-3
|
|
Wolfe C A C, Hage D S. Studies on the rate and controlof antibody oxidation by periodate. AnalyticalBiochemistry, 1995, 231(1): 123―130
doi: 10.1006/abio.1995.1511
|
|
Tian W M, Zhang C L, Hou S P, et al. Hyaluronic acid hydrogel as Nogo-66 receptorantibody delivery system for the repairing of injured rat brain: in vitro. Journalof Controlled Release, 2005, 102(1): 13―22
doi: 10.1016/j.jconrel.2004.09.025
|
|
Noh I, Kim G-W, Choi Y-J, et al. Effects of cross-linking molecular weights ina hyaluronic acid-poly(ethylene oxide) hydrogel network on its properties. Biomedical Materials, 2006, 1: 116―123
doi: 10.1088/1748-6041/1/3/004
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|