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Synthesis and characterization of a pH/temperature
responsive glycine-mediated hydrogel for drug release |
| Kui-lin DENG,Peng-fei ZHANG,Xiao-bo REN,Hai-bin ZHONG,Yu-bo GOU,Li-rong DONG,Qian LI, |
| College of Chemistry
& Environmental Science, Hebei University, Baoding 071002, China; |
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Abstract In this work, a pH/temperature responsive hydrogel (PMEA) from N-acryloylglycine methyl ester (NAGME), N-acryloylglycine ethyl ester (NAGEE), and acrylic acid (AAc) was synthesized by free radical polymerization. The swelling behaviors and drug release properties of hydrogels were systematically investigated at different temperature, pH, and AAc content. It was found that the hydrogel PMEA demonstrated pH and temperature responsive nature. The caffeine-release behaviors showed that only 49.1% caffeine was released from PMEA in pH 2.70 phosphate buffer solution (PBS) after 500 minutes, whereas more than 93.9% caffeine was gradually diffused into the medium in pH 7.49 PBS over the same time interval. In addition, the caffeine release was much higher at 37°C than that at 14°C in deionized water. As seen from the results, the PMEA seems to be a potential drug carrier with pH-temperature responsiveness.
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| Keywords
pH/temperature-responsive
N-acryloyl glycinate
drug release
polymer gels
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Issue Date: 05 December 2009
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