|
|
Effect of AAc-GA content on swelling behaviors
of temperature-sensitive PNIPAAm-based hydrogels |
You-Yu DONG1,Li CHEN1,Hao-Jie LI1,Xiao-Ling HE2,Fan-Yong YAN3, |
1.Tianjin Key Laboratory
of Fiber Modification and Functional Fiber, School of Materials Science
and Engineering, Tianjin Polytechnic University, Tianjin 300160,
China; 2.Tianjin Key Laboratory
of Fiber Modification and Functional Fiber, School of Materials Science
and Engineering, Tianjin Polytechnic University, Tianjin 300160,
China;School of Environment
and Chemical Engineering, Tianjin Polytechnic University, Tianjin
300160, China; 3.School of Environment
and Chemical Engineering, Tianjin Polytechnic University, Tianjin
300160, China; |
|
|
Abstract A series of temperature-sensitive poly(NIPAAm-co-AAc-GA) hydrogels were synthesized by the copolymerization of glycyrrhetinic acid with vinyl monomer (AAc-GA) and N-isopropylacrylamide (NIPAAm) in N, N-dimethylformamide (DMF). Since GA has the specific binding capacity to asialoglycoprotein receptors on the membrane of hepatocyte, the hydrogel with GA could be expected as good candidate for hepatic cell culture. The results showed that macroporous and channel network structure was formed in the hydrogel matrix. With increasing the AAc-GA content, the swelling ratios of hydrogels and lower critical solution temperature (LCST) increased because of the hydrophilic group of AAc-GA and the macroporous structure. In addition, the prepared hydrogels could respond quickly to temperature and exhibited good reversible temperature-responsive characteristics.
|
Keywords
glycyrrhetinic acid
temperature-responsive
N-isopropylacrylamide (NIPAAm)
hydrogel
|
Issue Date: 05 March 2010
|
|
|
Lee K Y, Mooney D J. Hydrogels for tissue engineering. Chemical Reviews, 2001, 101(7): 1869–1879
doi: 10.1021/cr000108x
|
|
Hoffman A S. Hydrogels for biomedical applications. Annals of the New York Academy of Science, 2001, 944(0): 62–73
|
|
Serizawa T, Wakita K, Akashi M. Rapid deswelling of porous poly(N-isopropylacrylamide)hydrogels prepared by incorporation of silica particles. Macromolecules, 2002, 35(1): 10–12
doi: 10.1021/ma011362+
|
|
Shi J, Alves N M, Mano J F. Thermally smart temperature-responsive biomineralizationonto biodegradable polymeric substrates. Advanced Functional Materials, 2007, 17(16): 3312– 3318
doi: 10.1002/adfm.200601206
|
|
Jeong B, Kim S W, Bae Y H. Thermo-sensitive sol-gel reversible hydrogels. Advanced Drug Delivery Reviews, 2002, 54(1): 37–51
doi: 10.1016/S0169-409X(01)00242-3
|
|
Xue W, Hamley I W, Huglin M B. Rapid swelling and deswelling of thermoreversible hydrophobicallymodified poly(N-isopropylacrylamide) hydrogels prepared by freezingpolymerisation. Polymer, 2002, 43(19): 5181–5186
doi: 10.1016/S0032-3861(02)00396-8
|
|
Leroux J C, Roux E, Garrec D L, et al. N-isopropylacrylamide copolymers for the preparationof pH-sensitive liposomes and polymeric micelles. Journal of Controlled Release, 2001, 72(1–3): 71–84
doi: 10.1016/S0168-3659(01)00263-2
|
|
Zhu P W, Napper D H. Effect of heating rate onnanoparticle formation of poly(N-isopropylacrylamide)-poly(ethyleneglycol) block copolymer microgels. Langmuir, 2000, 16(22): 8543–8545
doi: 10.1021/la000489+
|
|
Zhao Y, Cao Y, Yang Y L, et al. Rheological study of the sol-gel transitionof hybrid gel. Macromolecules, 2003, 36(3): 855–859
doi: 10.1021/ma020919y
|
|
He X L, Yu S, Dong Y Y, et al. Preparation and properties of a novel thermo-responsivepoly(N-isopropylacrylamide) hydrogel containing glycyrrhetinic acid. Journal of Materials Science, 2009, 44(15): 4078–4086
doi: 10.1007/s10853-009-3588-3
|
|
Zhang X Z, Yang Y Y, Wang F J, et al.. Thermosensitive poly(N-isopropylacrylamide-co-acrylicacid) hydrogels with expanded network structures and improved oscillatingswelling-deswelling properties. Langmuir, 2002, 18(6): 2013–2018
doi: 10.1021/la011325b
|
|
Li X Y, Wu W H, Liu W Q. Synthesis and properties of thermo-responsive guar gum/poly(N-isopropylacrylamide)interpenetrating polymer network hydrogels. Carbohydrate Polymers, 2008, 71(3): 394–402
doi: 10.1016/j.carbpol.2007.06.005
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|