Interactions between neural stem cells and biomaterials combined with biomolecules

doi:10.1007/s11706-010-0113-1

Front Mater Sci Chin

2010, Vol. 4

Issue (4) : 325-331 https://doi.org/10.1007/s11706-010-0113-1

REVIEW ARTICLE

Interactions between neural stem cells and biomaterials combined with biomolecules

Ying WANG¹, Hua DENG^1,2, Zhao-Hui ZU³, Xing-Can SHEN², Hong LIANG², Fu-Zhai CUI¹(

), Qun-Yuan XU⁴, In-Seop LEE⁵

1. Institute of Regenerative Medical and Biomimetic Materials, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China; 2. School of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin 541004, China; 3. Department of Neurosurgery, FuXing Hospital, Capital Medical University, Beijing 100038, China; 4. Beijing Institute of Neuroscience, Capital Medical University, Beijing 100069, China; 5. Institute of Physics and Applied Physics, Yonsei University, Seoul 120749, Korea

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Abstract

Neural repair and regeneration have been a tough problem in clinical studies. Tissue engineering using biomaterials along with neural stem cells (NSCs) have shown great potential for treatment, especially along with the biomolecules to regulate the NSCs can get more promising results. The biomolecules in the materials have a favorable impact on cell adhes ion, expansion, and differentiation. Thus, the interactions between biomaterials loading biomolecules and NSCs also receive particular attention. In this review, recent progresses of modified biomaterials by such biomolecules for neural injury and their impact on NSCs behavior will be discussed.

Keywords biomaterial neural stem cell (NSC) tissue engineering biomolecule

Corresponding Author(s): CUI Fu-Zhai,Email:cuifz@mail.tsinghua.edu.cn

Issue Date: 05 December 2010

Cite this article:

Ying WANG,Hua DENG,Zhao-Hui ZU, et al. Interactions between neural stem cells and biomaterials combined with biomolecules[J]. Front Mater Sci Chin, 2010, 4(4): 325-331.

URL:

https://academic.hep.com.cn/foms/EN/10.1007/s11706-010-0113-1
https://academic.hep.com.cn/foms/EN/Y2010/V4/I4/325

Fig.1 The strategy of neural repair and regeneration using biomaterial scaffold loading bioactive factors. The ideal biomaterials were prepared for three-dimensional scaffold. The bioactive factors can be modified directly on the scaffold or loaded by other small vehicles. Then, the neural stem cells (NSCs) were seeded on the scaffold and transplanted into the injury tissue for repair. The materials with bioactive factors can influence the survival, proliferation, and differentiation of transplanted NSCs and induce neurogenesis of endogenous NSCs in SVZ or SGZ, and so on. Moreover, they can perform more effective interactions with the surrounding tissues. Therefore, the complex gets much better improvement for neural regeneration.

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